scholarly journals External Validation of the Swedvasc Registry: A First-time Individual Cross-matching with the Unique Personal Identity Number

2008 ◽  
Vol 36 (6) ◽  
pp. 705-712 ◽  
Author(s):  
T. Troëng ◽  
J. Malmstedt ◽  
M. Björck
2009 ◽  
Vol 24 (11) ◽  
pp. 659-667 ◽  
Author(s):  
Jonas F. Ludvigsson ◽  
Petra Otterblad-Olausson ◽  
Birgitta U. Pettersson ◽  
Anders Ekbom

Author(s):  
Berend R. Beumer ◽  
Kosei Takagi ◽  
Bastiaan Vervoort ◽  
Stefan Buettner ◽  
Yuzo Umeda ◽  
...  

Abstract Background This study aimed to assess the performance of the pre- and postoperative early recurrence after surgery for liver tumor (ERASL) models at external validation. Prediction of early hepatocellular carcinoma (HCC) recurrence after resection is important for individualized surgical management. Recently, the preoperative (ERASL-pre) and postoperative (ERASL-post) risk models were proposed based on patients from Hong Kong. These models showed good performance although they have not been validated to date by an independent research group. Methods This international cohort study included 279 patients from the Netherlands and 392 patients from Japan. The patients underwent first-time resection and showed a diagnosis of HCC on pathology. Performance was assessed according to discrimination (concordance [C] statistic) and calibration (correspondence between observed and predicted risk) with recalibration in a Weibull model. Results The discriminatory power of both models was lower in the Netherlands than in Japan (C statistic, 0.57 [95% confidence interval {CI} 0.52–0.62] vs 0.69 [95% CI 0.65–0.73] for the ERASL-pre model and 0.62 [95% CI 0.57–0.67] vs 0.70 [95% CI 0.66–0.74] for the ERASL-post model), whereas their prognostic profiles were similar. The predictions of the ERASL models were systematically too optimistic for both cohorts. Recalibrated ERASL models improved local applicability for both cohorts. Conclusions The discrimination of ERASL models was poorer for the Western patients than for the Japanese patients, who showed good performance. Recalibration of the models was performed, which improved the accuracy of predictions. However, in general, a model that explains the East–West difference or one tailored to Western patients still needs to be developed.


2020 ◽  
Vol 53 (1-2) ◽  
pp. 21-31
Author(s):  
Igor Maver

The article for the first time ever explores the recent non-fiction and poetry by the contemporary Australian writer Krissy Kneen, who has Slovenian roots through her maternal grandmother. Kneen’s writing, a literary tribute to her late grandmother Dragitca (Dragica Marušič), shows a desire to come to terms with her partly ‘Slovenian’ gut microbiome and DNA, as she herself claims. They, in her view, along with the other elements in the process of identity formation, interestingly importantly help to constitute an ethnic identity and, for that matter, any personal identity. This makes her writing very original within the extant diasporic literary production.


2021 ◽  
Vol 104 ◽  
pp. 02005
Author(s):  
Olena Olifer

The article considers the introduction of the problem of personal identity in the structure of the course of philosophy. The introduction of new material is the attempt to redesign the academic course of philosophy, simultaneously keeping its traditional structure. The problem of personal identity is a topical issue in analytic philosophy. However, it is not much learnt in Ukraine, where academic circles mostly orient to continental philosophy. The paper analyses the subject area of personal identity: its metaphysical status, the nature and conditions of personhood, the possible criteria, and the method of though-experiment. Then, it shows the steps of introducing personal identity in the course of philosophy. The novelty of the article is in the fact that the problem of personal identity is introduced for non-philosophy students for the first time at Ukrainian university course of philosophy.


Author(s):  
Madiou Thierno Bah ◽  
Vladimir Grobois ◽  
Frédéric Stachurski ◽  
facundo munoz ◽  
Maxime Duhayon ◽  
...  

For the first time we built a correlative model for predicting the distribution of H. marginatum, one of the main vector of Crimean-Congo Haemorrhagic fever virus (CCHFV), at high resolution in a recently colonized area, namely south of France. Field tick collections were conducted on horses from 2016 to 2021 in 14 French southern departments, which resulted in a first map of H. marginatum on the national territory. Such updated presence/absence data, as well as the mean number of H. marginatum per examined animal (mean parasitic load) as a proxy of the tick abundance, were correlated to multiple parameters that described the climate and habitats characterizing each collection site, as well as movements of horses as a possible source of tick diffusion and new establishment. Our model highlighted the importance of warm temperatures all along the year, as well as dry conditions during summer and moderate annual humidity for the establishment of H. marginatum. A predominance of open natural habitats in the environment was also identified as a supporting factor, in opposition to artificial and humid habitats that were determined as unsuitable. Based on this model, we predicted the current suitable areas for the establishment of the tick H. marginatum in South of France, with a relatively good accuracy using internal and external validation methods. Concerning tick abundance, some correlative relationships were similar than in the occurrence model but the type of horse movements were also pointed out as an important factor explaining the mean parasitic load, leading to differential exposure to ticks. The limitations of estimating and modelling H. marginatum abundance in a correlative model are discussed.


This book is a collection of essays, most of which appear here for the first time, that were written in honour of the legendary moral philosopher, Derek Parfit. The essays are mainly concerned with issues that Parfit addressed in his book, Reasons and Persons. They include the relevance of personal identity to ethics, the rationality of different attitudes to time, the nature of well-being, the varieties of consequentialism, reasons for action, aggregation in ethics, causal overdetermination, egalitarianism, prioritarianism, and supererogation.


2015 ◽  
Vol 75 (4) ◽  
pp. 674-680 ◽  
Author(s):  
E E A Arts ◽  
C D Popa ◽  
A A Den Broeder ◽  
R Donders ◽  
A Sandoo ◽  
...  

ObjectivesPredictive performance of cardiovascular disease (CVD) risk calculators appears suboptimal in rheumatoid arthritis (RA). A disease-specific CVD risk algorithm may improve CVD risk prediction in RA. The objectives of this study are to adapt the Systematic COronary Risk Evaluation (SCORE) algorithm with determinants of CVD risk in RA and to assess the accuracy of CVD risk prediction calculated with the adapted SCORE algorithm.MethodsData from the Nijmegen early RA inception cohort were used. The primary outcome was first CVD events. The SCORE algorithm was recalibrated by reweighing included traditional CVD risk factors and adapted by adding other potential predictors of CVD. Predictive performance of the recalibrated and adapted SCORE algorithms was assessed and the adapted SCORE was externally validated.ResultsOf the 1016 included patients with RA, 103 patients experienced a CVD event. Discriminatory ability was comparable across the original, recalibrated and adapted SCORE algorithms. The Hosmer–Lemeshow test results indicated that all three algorithms provided poor model fit (p<0.05) for the Nijmegen and external validation cohort. The adapted SCORE algorithm mainly improves CVD risk estimation in non-event cases and does not show a clear advantage in reclassifying patients with RA who develop CVD (event cases) into more appropriate risk groups.ConclusionsThis study demonstrates for the first time that adaptations of the SCORE algorithm do not provide sufficient improvement in risk prediction of future CVD in RA to serve as an appropriate alternative to the original SCORE. Risk assessment using the original SCORE algorithm may underestimate CVD risk in patients with RA.


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