<p>Recent research has demonstrated the multidimensional and multi-sectoral impacts of climate change, evidencing the need to develop national and sub-national integrated tools and policies for the analysis of impacts and adaptation, especially central to local policy recommendation and implementation. This framework combines an area-based economic optimization model with the hydrological model WEAP, and represents the socio-economic, agronomic, and hydrologic systems in a spatially explicit manner covering dimensions and scales relevant to downscaled climate change impacts.&#160; Simulated scenarios are setup to incorporate climate scenario, prior-historic dependence to adaptation conformity, and two policy-based adaptation scenarios. Preliminary results indicate that climate change may impact severely in rain-fed agricultural area and also to irrigation systems reducing water availability and security and crop yields, and increasing in more efficient irrigation water allocation.&#160; The adaptation strategies analysis based on socio-economic, agronomic, and hydrologic dimensions capitalizes the key role of Thailand supply- and demand-side management policy in facilitating adaptation. The under developing framework is currently anticipated to be a useful tool for supporting water resources and climate change policy making.&#160; It can contribute to improve understanding on potential impacts of climate change, multi-sectoral linkages, multi-scale vulnerability, and adaptation programs. &#160;&#160;</p>