Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women

2015 ◽  
Vol 142 ◽  
pp. 10-16 ◽  
Author(s):  
Tamara Schikowski ◽  
Mohammad Vossoughi ◽  
Andrea Vierkötter ◽  
Thomas Schulte ◽  
Tom Teichert ◽  
...  
Author(s):  
А.В. Суханов ◽  
А.А. Гуражева ◽  
Д.В. Денисова ◽  
В.Н. Максимов

Ген APOE - это один из наиболее известных генов, ассоциированных с развитием как сердечно-сосудистых, так и нейродегенеративных заболеваний центральной нервной системы, сопровождающихся нарушением когнитивных функций (КФ). В ходе настоящего исследования изучены ассоциации аллелей гена APOE с нарушением КФ у подростков г. Новосибирска. Состояние КФ было оценено у 231 мальчика (42,1%) и у 318 девочки (57,9%). Их средний возраст составил 15,66 ± 0,9 года. Выявлено, что наличие аллеля Е4 оказывает негативное влияние на состояние рабочей памяти уже в подростковом возрасте. The APOE gene is one of the most famous genes associated with the development of both cardiovascular diseases and neurodegenerative diseases of the central nervous system, accompanied by impaired cognitive functions. In the course of this study, the associations of APOE gene alleles with cognitive functions violation in the adolescent population of Novosibirsk were studied. The state of cognitive functions was evaluated in 231 boys (42.1%) and 318 girls (57.9%). Their average age was 15.66 ± 0.9 years. It was revealed that the presence of the E4 allele of the APOE gene has a negative effect on the state of working memory even in adolescence.


2014 ◽  
Vol 1 (2) ◽  
pp. 141-143
Author(s):  
Neetha Kundoor ◽  
◽  
Ayana Joy ◽  
Mukkadan J K

Author(s):  
Remigija Dekaminavičiūtė ◽  
Vilma Dudonienė

Research background. Aging constantly manifests itself not only in physiological changes, but also in cognitive ones. Exercise programs for elderly have been created aiming at avoiding risk of falling, but there is little known about changes in cognitive functions under the effect of exercise. The aim was to evaluate the effect of water-based and land-based exercises on balance and cognitive functions in elderly women and men. Methods. The dynamic balance of study participants (n = 32) was evaluated using Timed Up & Go Test, the static balance was evaluated with a 4-position Static Balance Test and the cognitive functions were evaluated with Six-Item Cognitive Impairment Test, the Cognitive Failures Questionnaire and the Trail Making Test. The participants were randomly divided in two groups: water exercise and land-based exercise. Results. After 8 weeks of exercise in water and on land, static and dynamic balance and cognitive functions improved in both groups (p < 0.05), no statistically signifcant difference was found between the groups except for the trail making test, which was performed more quickly by subjects who attended exercise in water. After the exercise program, the men’s dynamic and static balance (while standing in the tandem position) were better than women’s, but women’s standing on one leg position was better than that of men’s (p < 0.05). Conclusion. There were no statistically signifcant differences in cognitive function between men and women after intervention. After both exercise programs, dynamic and static balance (in the tandem position) in men were better (p < 0.05) than those in women, standing on one leg but women’s position was statistically signifcantly better than that of men’s.Keywords: exercise program in water and land-based, static and dynamic balance, cognitive functions.


2017 ◽  
Vol 137 (5) ◽  
pp. S26
Author(s):  
W. Schnass ◽  
A. Hüls ◽  
A. Vierkötter ◽  
J. Xia ◽  
U. Krämer ◽  
...  
Keyword(s):  

2011 ◽  
Vol 27 (9) ◽  
pp. 1827-1836 ◽  
Author(s):  
Marcio Sacramento de Oliveira ◽  
Antônio Ponce de Leon ◽  
Inês Echenique Mattos ◽  
Sérgio Koifman

This study analyzed the association between air pollution and deaths from respiratory diseases, considering differential susceptibility according to gender. The authors used daily deaths from respiratory diseases (ICD-10, J00-J99), PM10, SO2, and O3 levels, and meteorological indicators in Volta Redonda, Rio de Janeiro State, Brazil, from January 2002 to December 2006. The association was estimated by Poisson regression using generalized additive models, where the increase in risk of deaths from PM10 to lag 1 was 10.01% (95%CI: 1.81-18.88%) in the total female population and 10.04% (95%CI: 0.90-20.02%) in elderly women. The increase in risk of deaths from PM10 to lag 9 was 8.25% in the total male population (95%CI: 0.86-16.18%) and 10.80% (95%CI: 2.18-20.15%) in elderly men. For exposure to SO2 and O3, the risk was significant in the total male population and the elderly, respectively. The results emphasize the need for further studies, focusing on modification of the effects of air pollution on health.


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