scholarly journals Blood lead levels and aberrant DNA methylation of the ALAD and p16 gene promoters in children exposed to environmental-lead

2020 ◽  
Vol 188 ◽  
pp. 109759 ◽  
Author(s):  
Yared B. Yohannes ◽  
Shouta MM. Nakayama ◽  
John Yabe ◽  
Hokuto Nakata ◽  
Haruya Toyomaki ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Gene Promoters ◽  
P16 Gene ◽  
Environmental Lead ◽  
Lead Levels ◽  
Aberrant Dna Methylation

scholarly journals Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999–2016

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Man Fung Tsoi ◽  
Chris Wai Hang Lo ◽  
Tommy Tsang Cheung ◽  
Bernard Man Yung Cheung
Keyword(s):  
Blood Pressure ◽  
Lead Exposure ◽  
Blood Lead Level ◽  
Lead Level ◽  
Blood Lead ◽  
The United States ◽  
Study Data ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels

AbstractLead is a heavy metal without a biological role. High level of lead exposure is known to be associated with hypertension, but the risk at low levels of exposure is uncertain. In this study, data from US NHANES 1999–2016 were analyzed. Adults with blood lead and blood pressure measurements, or self-reported hypertension diagnosis, were included. If not already diagnosed, hypertension was defined according to the AHA/ACC 2017 hypertension guideline. Results were analyzed using R statistics version 3.5.1 with sample weight adjustment. Logistic regression was used to study the association between blood lead level and hypertension. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated. Altogether, 39,477 participants were included. Every doubling in blood lead level was associated with hypertension (OR [95%CI] 1.45 [1.40–1.50]), which remained significant after adjusting for demographics. Using quartile 1 as reference, higher blood lead levels were associated with increased adjusted odds of hypertension (Quartile 4 vs. Quartile 1: 1.22 [1.09–1.36]; Quartile 3 vs. Quartile 1: 1.15 [1.04–1.28]; Quartile 2 vs. Quartile 1: 1.14 [1.05–1.25]). In conclusion, blood lead level is associated with hypertension in the general population with blood lead levels below 5 µg/dL. Our findings suggest that reducing present levels of environmental lead exposure may bring cardiovascular benefits by reducing blood pressure.

Question Regarding Need for Treatment

PEDIATRICS ◽  
1975 ◽  
Vol 56 (4) ◽  
pp. 621-622
Author(s):  
Arthur W. Kaemmer ◽  
Byron R. Johnson
Keyword(s):  
Mass Screening ◽  
Lead Poisoning ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Elevated Blood ◽  
Screening Programs ◽  
Environmental Lead ◽  
Need For Treatment ◽  
Lead Levels ◽  
Elevated Blood Lead Levels

Dr. Greensher and his colleagues are to be congratulated for bringing to the readers' attention a most unusual source of lead poisoning. Inasmuch as many localities are initiating city-wide lead screening programs, it is obvious that pediatricians in this country will be seeing many children with abnormally elevated blood lead levels, and in many cases diligent efforts such as this will have to be undertaken to determine the exact source of the environmental lead. biggest problems with mass screening programs for lead poisoning are well outlined by Moriarty's article.2

Predicting the Children's Blood Lead Level in a Lead and Zinc Smelting Area Based on IEUBK Model

2015 ◽  
Vol 1092-1093 ◽  
pp. 687-691
Author(s):  
Fei Chen ◽  
Hong Guang Cheng ◽  
Xiang Fen Cui
Keyword(s):  
Lead Concentration ◽  
Lead Level ◽  
Blood Lead ◽  
Blood Lead Concentration ◽  
Blood Lead Levels ◽  
Prediction Ability ◽  
Environmental Lead ◽  
Lead And Zinc ◽  
Zinc Smelting ◽  
Lead Levels

According to environmental lead exposure data and dietary survey data of lead and zinc smelting area,blood lead levels of children (2~7years old) in study area were predicted with IEUBK model. The children's blood lead concentration predicted value was compared with the corresponding measured value,by comparing the differences, measured the prediction ability of model. The results showed that predicted value and measured value of 2~7 years old children's blood lead concentration in A village were higher than the other villages, they were 33.5μg/dL,30.8μg/dL, respectively; predicted value and measured value of 2~7 years old children's blood lead concentration in I village were the lowest among all villages,they were14.5μg/dL,13.1μg/dL, respectively.By paired T-test showed that the predicted value were higher than the measured value about 1.4~3.4μg/dL,model calculation results slightly overestimated the children's blood lead level.But in general, the predicted value and measured value had a good consistency,through the model prediction could better reflect the children's blood lead levels in the study area.

The relationship of environmental lead to blood-lead levels in children

1982 ◽  
Vol 27 (2) ◽  
pp. 372-383 ◽  
Author(s):  
Alice D. Stark ◽  
Ruth Fitch Quah ◽  
J.Wister Meigs ◽  
Edward R. DeLouise
Keyword(s):  
Blood Lead ◽  
Blood Lead Levels ◽  
Environmental Lead ◽  
Lead Levels ◽  
Relationship Of ◽  
The Relationship

Community prevalence survey of children's blood lead levels and environmental lead contamination in inner Sydney

1992 ◽  
Vol 157 (7) ◽  
pp. 441-445 ◽  
Author(s):  
Michael J Fett ◽  
Michael Mira ◽  
Jason Smith ◽  
Jane Causer ◽  
Tim Brokenshire ◽  
...  
Keyword(s):  
Blood Lead ◽  
Lead Contamination ◽  
Blood Lead Levels ◽  
Prevalence Survey ◽  
Environmental Lead ◽  
Lead Levels

scholarly journals Environmental Lead Pollution and Elevated Blood Lead Levels Among Children in a Rural Area of China

2011 ◽  
Vol 101 (5) ◽  
pp. 834-841 ◽  
Author(s):  
Sihao Lin ◽  
Xiaorong Wang ◽  
Ignatius Tak Sun Yu ◽  
Wenjuan Tang ◽  
Jianying Miao ◽  
...  
Keyword(s):  
Rural Area ◽  
Blood Lead ◽  
Blood Lead Levels ◽  
Lead Pollution ◽  
Elevated Blood ◽  
Environmental Lead ◽  
Lead Levels ◽  
Elevated Blood Lead Levels

scholarly journals COWS AND GOATS AS SENTINELS FOR ENVIRONMENTAL LEAD (Pb) BURDEN IN ZARIA, NIGERIA

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Udiba Udiba Ugumanim ◽  
Ibrahim Moses ◽  
Chindo Hilda Jonah ◽  
Zakariyya Ahmad ◽  
Dawaki Saleh Idris ◽  
...  
Keyword(s):  
Atomic Absorption ◽  
Blood Lead ◽  
Mean Value ◽  
Blood Lead Levels ◽  
Human Consumption ◽  
Indirect Measure ◽  
Geochemical Environment ◽  
Environmental Lead ◽  
Lead Levels ◽  
Capra Aegagrus

Blood lead levels (BLLs) is considered as a good indicator of current body burden of the toxic metal. Assessment of BLLs of white Fulani cattle(Bos primigenius indicus)and red Sokoto goats (Capra aegagrus hircus) grazed freely on open pastures in Zaria was carried out by Atomic Absorption Spectrophotometry using Shimadzu Atomic Absorption Spectrophotometer (model AA-6800, Japan) after wet digestion to evaluate the potential effects of the metal on the animals, the toxicological implication of consuming this major source of animal protein by humans and most importantly as an indirect measure of the lead pollution status of Zaria ecological geochemical environment. The blood lead levels of Bos primigenius indicus ranged from a minimum of 0.62 mg/l to a maximum of 2.28 mg/l with a mean value of 1.36±0.48 mg/l. On the other hand, blood lead levels of Capra aegagrus hircus ranged between 0.26 mg/l and 1.56 mg/l with a mean value of 0.89±0.43mg/l. The BLLs of both cows and goats were found to exceed the allowable limit for the elements in blood of food animals indicating that cows and goats grazed freely on open pastures in Zaria metropolis are not safe for human consumption. Routine monitoring of the heavy metal in plant and animal products is therefore recommended to safeguard human health. Most importantly, the study indicates the presence of elevated levels of environmental lead in Zaria ecological geochemical environment.

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