Coexistence of idiopathic generalized epilepsy among surgically treated patients with drug-resistant temporal lobe epilepsy

2011 ◽  
Vol 96 (1-2) ◽  
pp. 151-157 ◽  
Author(s):  
Ashalatha Radhakrishnan ◽  
Ramshekar N. Menon ◽  
Kurupath Radhakrishnan
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Drug Resistant ◽  
Idiopathic Generalized Epilepsy ◽  
Generalized Epilepsy

scholarly journals Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

2020 ◽  
Vol 6 (47) ◽  
pp. eabc6457
Author(s):  
Sara Larivière ◽  
Raúl Rodríguez-Cruces ◽  
Jessica Royer ◽  
Maria Eugenia Caligiuri ◽  
Antonio Gambardella ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Strong Influence ◽  
Healthy Controls ◽  
Negative Effects ◽  
Idiopathic Generalized Epilepsy ◽  
Cross Sectional ◽  
Distinct Disease ◽  
The Common ◽  
Generalized Epilepsy

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

scholarly journals Network-based atrophy modelling in the common epilepsies: a worldwide ENIGMA study

2020 ◽  
Author(s):  
Sara Larivière ◽  
Raúl Rodríguez-Cruces ◽  
Jessica Royer ◽  
Maria Eugenia Caligiuri ◽  
Antonio Gambardella ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Analytical Methods ◽  
Strong Influence ◽  
Healthy Controls ◽  
Idiopathic Generalized Epilepsy ◽  
Cross Sectional ◽  
Distinct Disease ◽  
The Common ◽  
Generalized Epilepsy

SUMMARYEpilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1,021 adults with epilepsy compared to 1,564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy co-localized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Indices of progressive atrophy further revealed a strong influence of connectome architecture on disease progression in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients, and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided novel insights into the macroscale features that shape the pathophysiology of common epilepsies.

CpG Methylation Signature Define Human Temporal Lobe Epilepsy and Predict Drug-Resistant

2019 ◽  
Author(s):  
Wenbiao Xiao ◽  
Chaorong Liu ◽  
Kuo Zhong ◽  
Shangwei Ning ◽  
Rui Hou ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cpg Methylation ◽  
Drug Resistant ◽  
Human Temporal Lobe

Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy

2009 ◽  
Vol 111 (6) ◽  
pp. 1237-1247 ◽  
Author(s):  
László Seress ◽  
Hajnalka Ábrahám ◽  
Zsolt Horváth ◽  
Tamás Dóczi ◽  
József Janszky ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Pyramidal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Drug Resistant ◽  
Hippocampal Dentate Gyrus ◽  
Mossy Cells ◽  
Mesial Temporal Lobe

Object Hippocampal sclerosis can be identified in most patients with mesial temporal lobe epilepsy (TLE). Surgical removal of the sclerotic hippocampus is widely performed to treat patients with drug-resistant mesial TLE. In general, both epilepsy-prone and epilepsy-resistant neurons are believed to be in the hippocampal formation. The hilar mossy cells of the hippocampal dentate gyrus are usually considered one of the most vulnerable types of neurons. The aim of this study was to clarify the fate of mossy cells in the hippocampus in epileptic humans. Methods Of the 19 patients included in this study, 15 underwent temporal lobe resection because of drug-resistant TLE. Four patients were used as controls because they harbored tumors that had not invaded the hippocampus and they had experienced no seizures. Histological evaluation of resected hippocampal tissues was performed using immunohistochemistry. Results Mossy cells were identified in the control as well as the epileptic hippocampi by using cocaine- and amphetamine-regulated transcript peptide immunohistochemistry. In most cases the number of mossy cells was reduced and thorny excrescences were smaller in the epileptic hippocampi than in controls; however, there was a significant loss of pyramidal cells and a partial loss of granule cells in the same epileptic hippocampi in which mossy cell loss was apparent. The loss of mossy cells could be correlated with the extent of hippocampal sclerosis, patient age at seizure onset, duration of epilepsy, and frequency of seizures. Conclusions In many cases large numbers of mossy cells were present in the hilus of the dentate gyrus when most pyramidal neurons of the CA1 and CA3 areas of the Ammon's horn were lost, suggesting that mossy cells may not be more vulnerable to epileptic seizures than the hippocampal pyramidal neurons.

Depressive disorder in a boy with drug resistant idiopathic generalized epilepsy

2012 ◽  
Vol 24 (2) ◽  
pp. 191-192
Author(s):  
I. Leo⁎ ◽  
D. Cordelli ◽  
V. Gentile ◽  
A. Barbieri ◽  
V. Marchiani ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Drug Resistant ◽  
Idiopathic Generalized Epilepsy ◽  
Generalized Epilepsy
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