Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats

2018 ◽  
Vol 60 ◽  
pp. 184-194 ◽  
Author(s):  
Ivaldo Jesus Almeida Belém-Filho ◽  
Paula Cardoso Ribera ◽  
Aline Lima Nascimento ◽  
Antônio Rafael Quadros Gomes ◽  
Rafael Rodrigues Lima ◽  
...  
Keyword(s):  
Binge Drinking ◽  
Female Rats ◽  
Adolescent Female ◽  
Low Doses ◽  
Methylmercury Intoxication

scholarly journals Repeated Cycles of Binge-Like Ethanol Intake in Adolescent Female Rats Induce Motor Function Impairment and Oxidative Damage in Motor Cortex and Liver, but Not in Blood

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Luanna Melo Pereira Fernandes ◽  
Klaylton Sousa Lopes ◽  
Luana Nazaré Silva Santana ◽  
Enéas Andrade Fontes-Júnior ◽  
Carolina Heitmann Mares Azevedo Ribeiro ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Binge Drinking ◽  
Motor Function ◽  
Young Adulthood ◽  
Alcohol Exposure ◽  
Ethanol Intake ◽  
Female Rats ◽  
Adolescent Female ◽  
Function Impairment ◽  
Female Wistar Rats

Moderate ethanol consumption (MEC) is increasing among women. Alcohol exposure usually starts in adolescence and tends to continue until adulthood. We aimed to investigate MEC impacts during adolescence until young adulthood of female rats. Adolescent female Wistar rats received distilled water or ethanol (3 g/kg/day), in a 3 days on-4 days off paradigm (binge drinking) for 1 and 4 consecutive weeks. We evaluate liver and brain oxidative damage, peripheral oxidative parameters by SOD, catalase, thiol contents, and MDA, and behavioral motor function by open-field, pole, beam-walking, and rotarod tests. Our results revealed that repeated episodes of binge drinking during adolescence displayed lipid peroxidation in the liver and brain. Surprisingly, such oxidative damage was not detectable on blood. Besides, harmful histological effects were observed in the liver, associated to steatosis and loss of parenchymal architecture. In addition, ethanol intake elicited motor incoordination, bradykinesia, and reduced spontaneous exploratory behavior in female rats.

Effect of low doses of continuously administered catecholoestrogens on peripheral and central target organs

1981 ◽  
Vol 96 (4) ◽  
pp. 470-474 ◽  
Author(s):  
Peter Ball ◽  
Günter Emons ◽  
Ulrich Gethmann
Keyword(s):  
Serum Levels ◽  
Female Rats ◽  
Low Doses ◽  
Vaginal Opening ◽  
Uterine Weight ◽  
Central Target ◽  
Male And Female Rats ◽  
Target Organs ◽  
Uterine Growth ◽  
Lh Release

Abstract. Osmotic minipumps containing low doses of either 4-hydroxyoestradiol or 2-hydroxyoestradiol2) were sc implanted for 152 h (6⅓ day) into immature male and female rats. At the end of the test period the animals were killed and the uterine weight, the vaginal opening, the gonadotrophin serum levels and the gonadal weight monitored. The following results were obtained: 1) a significant increase in the uterine weight and a consistent vaginal opening were observed after 4-hydroxyoestradiol but not after 2-hydroxyoestradiol treatment, 2) LH-levels increased after 2-hydroxyoestradiol but not after 4-hydroxyoestradiol; the increase was, however, not significant, 3) FSH-levels and gonadal weights were lowered by 4-hydroxyoestradiol treatment in male animals only; 2-hydroxyoestradiol had no effect on FSH-levels in both sexes, 4) in no instance an antioestrogenic effect of either catecholoestrogen was observed. It is concluded that 4-hydroxyoestrogens — using the above paradigm — have a significant importance on uterine growth and vaginal opening but (on day 6) no role on LH-release, whereas 2-hydroxyoestrogens may increase LH levels (on day 6) but are nearly ineffective with respect to peripheral parameters.

The effects of early‐life stress on dopamine system function in adolescent female rats

2017 ◽  
Vol 57 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Iwona Majcher‐Maślanka ◽  
Anna Solarz ◽  
Krzysztof Wędzony ◽  
Agnieszka Chocyk
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Adolescent Female ◽  
System Function ◽  
Dopamine System

scholarly journals Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

2020 ◽  
Vol 130 ◽  
pp. 110608 ◽  
Author(s):  
Cristiane Maia ◽  
Bruno Gonçalves Pinheiro ◽  
Carla Cristiane Soares da Silva ◽  
Rodrigo A. Cunha ◽  
Deiweson Souza-Monteiro ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Ethanol Consumption ◽  
Female Rats ◽  
Caffeine Intake ◽  
Adolescent Female ◽  
Bone Damage

scholarly journals Amomum villosum induces longitudinal bone growth in adolescent female rats

2012 ◽  
Vol 32 (3) ◽  
pp. 453-458 ◽  
Author(s):  
Sun Haeng Lee ◽  
Ji Young Kim ◽  
Hocheol Kim ◽  
Seul Ki Park ◽  
Cho Young Kim ◽  
...  
Keyword(s):  
Bone Growth ◽  
Female Rats ◽  
Adolescent Female ◽  
Longitudinal Bone Growth ◽  
Amomum Villosum

scholarly journals Chronic exposure to low doses of lipopolysaccharide and high-fat feeding increases body mass without affecting glucose tolerance in female rats

2015 ◽  
Vol 3 (11) ◽  
pp. e12584 ◽  
Author(s):  
Anete Dudele ◽  
Christina W. Fischer ◽  
Betina Elfving ◽  
Gregers Wegener ◽  
Tobias Wang ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Body Mass ◽  
Chronic Exposure ◽  
Female Rats ◽  
Low Doses ◽  
High Fat ◽  
Fat Feeding
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