scholarly journals Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

2020 ◽  
Vol 130 ◽  
pp. 110608 ◽  
Author(s):  
Cristiane Maia ◽  
Bruno Gonçalves Pinheiro ◽  
Carla Cristiane Soares da Silva ◽  
Rodrigo A. Cunha ◽  
Deiweson Souza-Monteiro ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Ethanol Consumption ◽  
Female Rats ◽  
Caffeine Intake ◽  
Adolescent Female ◽  
Bone Damage

scholarly journals Exposure and Loss of Environmental Enrichment Mediates Ethanol Consumption in Adolescent Female Rats

2019 ◽  
Vol 16 (3) ◽  
pp. 79-84
Author(s):  
Natalie Lipari ◽  
Max Baron ◽  
Joshua Peck
Keyword(s):  
Alcohol Use ◽  
Treatment Strategy ◽  
Environmental Enrichment ◽  
The United States ◽  
Ethanol Consumption ◽  
Adolescent Females ◽  
Female Rats ◽  
Adolescent Female ◽  
Drug Reinforcement ◽  
Alcohol Abstinence

Alcohol use among adolescent females has significantly increased in the United States with young women drinking alcohol at the same rate as young men. One potential treatment strategy that could help sustain alcohol abstinence is Environmental Enrichment (EE). Environmental enrichment is a process concerning the stimulation of the brain by one’s physical and social surrounding, which promotes non-drug reinforcement alternatives (e.g. voluntary exercise) supporting drug abstinence. Thus, the primary focus of this study was to investigate the effect of EE on ethanol (ETOH) abstinence in adolescent female rats. All adolescent female rats, starting on postnatal day 30, had 24-h access to 2%, then 4%, and then 6% ethanol concentrations. At the end of the four weeks, the environmental conditions were switched (EE→NEE and NEE→EE) and the 6% ethanol measure was repeated. We found that EE significantly reduced ethanol consumption for adolescent female rats compared to controls. Further, the removal of EE opportunities resulted in a significant increase in ethanol consumption. Collectively, the results suggest that access to enriched life conditions are important in facilitating alcohol abstinence in adolescent female rats. KEYWORDS: Adolescent Females; Alcohol Consumption; Environmental Enrichment; Alcohol Use Disorder; Treatment Strategy; Alcohol Abstinence; Ethanol; Adolescent Female Rats

scholarly journals Protective Effects of Moderate Ca Supplementation against Cd-Induced Bone Damage under Different Population-Relevant Doses in Young Female Rats

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 849 ◽  
Author(s):  
Huang ◽  
Liu ◽  
Zhao ◽  
Fu ◽  
Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Young Female ◽  
Female Rats ◽  
Bone Biomechanics ◽  
Protective Effects ◽  
Fibroblast Growth ◽  
Bone Damage

Estimation of the skeleton-protective effects of Ca in Cd-induced bone damage is helpful in the assessment of Cd health risk. The aim of this study was to identify whether Ca supplementation during exposure to different population-relevant doses of Cd can prevent Cd-induced bone damage under the tolerable upper intake level of Ca supplementation. Young female Sprague-Dawley rats were given different population-relevant doses of Cd (1, 5, and 50 mg Cd/kg diet) and Ca supplementation (0.4% Ca supplementation) intervention. Ca supplementation significantly decreased Cd-induced bone microstructure damage, increased bone biomechanics (p < 0.05), serum bone formation marker level (p < 0.05) and expression of osteogenic gene markers exposure to the 5 and 50 mg Cd/kg diets. However, it had no impact on these indicators under the 1 mg Cd/kg diets, with the exception of expression of osteogenic marker genes. Ca supplementation significantly decreased serum Klotho level (p < 0.05), and fibroblast growth factor 23/Klotho-associated gene expression in the kidney and bone showed significant changes. In conclusion, Ca supplementation has a positive effect on bone formation and bone quality against the damaging impact of Cd, especially with exposure to the 5 mg and 50 mg Cd/kg diet, which may be related to its impact on the fibroblast growth factor 23/Klotho axis.

The effects of early‐life stress on dopamine system function in adolescent female rats

2017 ◽  
Vol 57 (1) ◽  
pp. 24-33 ◽  
Author(s):  
Iwona Majcher‐Maślanka ◽  
Anna Solarz ◽  
Krzysztof Wędzony ◽  
Agnieszka Chocyk
Keyword(s):  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Female Rats ◽  
Adolescent Female ◽  
System Function ◽  
Dopamine System

scholarly journals The Effects ofCosmos caudatuson Structural Bone Histomorphometry in Ovariectomized Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Norazlina Mohamed ◽  
Sharon Gwee Sian Khee ◽  
Ahmad Nazrun Shuid ◽  
Norliza Muhammad ◽  
Farihah Suhaimi ◽  
...  
Keyword(s):  
Bone Histomorphometry ◽  
Therapeutic Agent ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Antioxidant Compounds ◽  
Protective Agent ◽  
Cosmos Caudatus ◽  
Bone Damage ◽  
Trabecular Separation ◽  
Trabecular Number

Osteoporosis is considered a serious debilitating disease.Cosmos caudatus(ulam raja), a plant containing antioxidant compounds and minerals, may be used to treat and prevent osteoporosis. This study determines the effectiveness ofC. caudatusas bone protective agent in postmenopausal osteoporosis rat model. Thirty-two female rats, aged 3 months old, were divided into 4 groups. Group one was sham operated (sham) while group two was ovariectomized. These two groups were given ionized water by forced feeding. Groups three and four were ovariectomized and given calcium 1% ad libitum and force-fed withC. caudatusat the dose of 500 mg/kg, respectively. Treatments were given six days per week for a period of eight weeks. Body weight was monitored every week and structural bone histomorphometry analyses of the femur bones were performed. Ovariectomy decreased trabecular bone volume (BV/TV), decreased trabecular number (Tb.N), and increased trabecular separation (Tb.Sp). Both calcium 1% and 500 mg/kgC. caudatusreversed the above structural bone histomorphometric parameters to normal level.C. caudatusshows better effect compared to calcium 1% on trabecular number (Tb.N) and trabecular separation (Tb.Sp). Therefore,Cosmos caudatus500 mg/kg has the potential to act as the therapeutic agent to restore bone damage in postmenopausal women.

scholarly journals Effects of Chronic Ethanol Consumption and Ovariectomy on the Spontaneous Alveolar Bone Loss in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Priscila Cunha Nascimento ◽  
Leonardo Oliveira Bittencourt ◽  
Soraya O. Pinto ◽  
Luana N. S. Santana ◽  
Renata Duarte Souza-Rodrigues ◽  
...  
Keyword(s):  
Bone Loss ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Estrogen Deficiency ◽  
Female Rats ◽  
Chronic Ethanol Consumption ◽  
Female Wistar Rats ◽  
Postmenopausal Estrogen ◽  
Post Hoc ◽  
One Way Anova

Postmenopausal estrogen deficiency and ethanol (EtOH) abuse are known risk factors for different diseases including bone tissues. However, little is known about the synergic effects of EtOH abuse and estrogen deficiency on alveolar bone loss in women. The present study evaluated the effects of EtOH chronic exposure and ovariectomy on the alveolar bone loss in female rats. For this, 40 female Wistar rats were randomly divided into 4 groups: control, EtOH exposure, ovariectomy (OVX), and OVX plus EtOH exposure. Initially, half of the animals were ovariectomized at 75 days of age. After that, the groups received distilled water or EtOH 6.5 g/kg/day (20% w/v) for 55 days via gavage. Thereafter, animals were sacrificed and the mandibles were collected, dissected, and separated into hemimandibles. Alveolar bone loss was evaluated by measuring the distance between the cementoenamel junction and the alveolar bone crest through a stereomicroscope in 3 different anatomical regions of the tissue. One-way ANOVA and post hoc Tukey were used to compare groups ( p < 0.05 ). The results showed that the ovariectomy and EtOH exposure per se were able to induce alveolar bone loss, and their association did intensify significantly the effect. Therefore, OVX associated with heavy EtOH exposure increase the spontaneous alveolar bone loss in rats.

scholarly journals Chronic Ethanol Consumption Inhibits Postlactational Anabolic Bone Rebuilding in Female Rats

2007 ◽  
Vol 23 (3) ◽  
pp. 338-349 ◽  
Author(s):  
Kartik Shankar ◽  
Mats Hidestrand ◽  
Xiaoli Liu ◽  
Jin Ran Chen ◽  
Rani Haley ◽  
...  
Keyword(s):  
Ethanol Consumption ◽  
Chronic Ethanol ◽  
Female Rats ◽  
Chronic Ethanol Consumption

Low doses of methylmercury intoxication solely or associated to ethanol binge drinking induce psychiatric-like disorders in adolescent female rats

2018 ◽  
Vol 60 ◽  
pp. 184-194 ◽  
Author(s):  
Ivaldo Jesus Almeida Belém-Filho ◽  
Paula Cardoso Ribera ◽  
Aline Lima Nascimento ◽  
Antônio Rafael Quadros Gomes ◽  
Rafael Rodrigues Lima ◽  
...  
Keyword(s):  
Binge Drinking ◽  
Female Rats ◽  
Adolescent Female ◽  
Low Doses ◽  
Methylmercury Intoxication
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