S10FOXO1 MODIFIES ASSOCIATIONS BETWEEN MATERNAL DEPRESSION AND ANXIETY DURING PREGNANCY AND OFFSPRING PSYCHIATRIC PROBLEMS IN EARLY CHILDHOOD

Abstract Maternal depression and anxiety are potential risk factors to children's language environments and development. Though existing work has examined relations between these constructs, further work is needed accounting for both depression and anxiety and using more direct measures of the home language environment and children's language development. We examined 265 mother-infant dyads (49.6% female, Mage = 17.03 months) from a large city in the Western United States to explore the relations between self-reports of maternal depression and anxiety and observational indices of the home language environment and expressive language as captured by Language Environment Analysis (LENA) and parent-reported language comprehension and production. Results revealed maternal depressive symptoms to be negatively associated with home language environment and expressive language indices. Maternal anxiety symptoms were found to be negatively associated with children's parent-reported language production. These findings provide further evidence that maternal mental health modulates children's home language environments and expressive language.

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Impact of maternal depression and anxiety-related disorders on live birth rate in women with recurrent pregnancy loss

Human Fertility ◽

10.1080/14647273.2021.1953710 ◽

2021 ◽

pp. 1-8

Author(s):

Daisuke Shigemi ◽

Yohei Hashimoto ◽

Nobuaki Michihata ◽

Hideo Yasunaga

Keyword(s):

Maternal Depression ◽

Live Birth ◽

Pregnancy Loss ◽

Birth Rate ◽

Recurrent Pregnancy Loss ◽

Live Birth Rate ◽

Depression And Anxiety

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Maternal depression and anxiety: The relation between maternal self-reports of functioning and mother-infant interaction

Infant Behavior and Development ◽

10.1016/s0163-6383(98)91963-4 ◽

1998 ◽

Vol 21 ◽

pp. 750

Author(s):

M.Katherine Weinberg ◽

Edward Z. Tronick ◽

Lee S. Cohen ◽

Karen L. Olson

Keyword(s):

Maternal Depression ◽

Depression And Anxiety ◽

Self Reports

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Maternal Depression in Early Childhood and Developmental Vulnerability at School Entry

International Journal for Population Data Science ◽

10.23889/ijpds.v5i5.1425 ◽

2020 ◽

Vol 5 (5) ◽

Author(s):

Elizabeth Wall-Wieler ◽

Leslie L. Roos ◽

Ian Gotlib

Keyword(s):

Early Childhood ◽

Maternal Depression ◽

Well Being ◽

Population Based ◽

School Entry ◽

Childhood Development ◽

Small Samples ◽

Physician Visits ◽

Developmental Domains ◽

The Relationship

IntroductionStudies on the relationship between exposure to maternal depression in early childhood and childhood development have been limited by small samples, lack of information on timing of maternal depression, and use of a composite measure of childhood development. Objectives and ApproachWe linked multiple Manitoba datasets to examine the relationship between exposure to maternal depression in early childhood and childhood development at school entry across five domains, and age at exposure to maternal depression on developmental outcomes using a population-based cohort (n = 52,103). Maternal depression was defined using physician visits, hospitalizations, and pharmaceutical data, while developmental vulnerability was assessed using the well-validated Early Development Instrument. Relative risk of developmental vulnerability was assessed using log-binomial regression models, adjusted for maternal and childhood characteristics at the birth of the child. ResultsChildren exposed to maternal depression before age 5 had a 17% higher risk of having at least one developmental vulnerability at school entry than children not exposed to such depression before age 5. Exposure to maternal depression before age 5 was most strongly associated with social competence (aRR = 1.28, 95% CI 1.20, 1.38), physical health and well-being (aRR = 1.28, 95% CI 1.20, 1.36), and emotional maturity (aRR = 1.27, 95% CI 1.18, 1.37). For most developmental domains, exposure to maternal depression before age 1 and between ages 4 and 5 had the greatest association with developmental vulnerability. Conclusion / ImplicationsOur findings that children exposed to maternal depression were at higher risk of developmental vulnerability at school entry is consistent with previous studies. However, we found that the association between exposure to maternal depression and development varied across developmental domains, and the relationship varied depending on the age of exposure to maternal depression. Ongoing analyses of discordant cousins will shed more light on the causal nature of this relationship.

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The Long-Term Effects of Maternal Depression: Early Childhood Physical Health as a Pathway to Offspring Depression

Journal of Adolescent Health ◽

10.1016/j.jadohealth.2013.07.038 ◽

2014 ◽

Vol 54 (1) ◽

pp. 88-93 ◽

Cited By ~ 49

Author(s):

Elizabeth Raposa ◽

Constance Hammen ◽

Patricia Brennan ◽

Jake Najman

Keyword(s):

Early Childhood ◽

Physical Health ◽

Maternal Depression ◽

Long Term Effects

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Intergenerational transmission of adverse childhood experiences via maternal depression and anxiety and moderation by child sex

Journal of Developmental Origins of Health and Disease ◽

10.1017/s2040174418000648 ◽

2018 ◽

Vol 10 (1) ◽

pp. 88-99 ◽

Cited By ~ 18

Author(s):

N. Letourneau ◽

D. Dewey ◽

B. J. Kaplan ◽

H. Ntanda ◽

J. Novick ◽

...

Keyword(s):

Mental Health ◽

Maternal Depression ◽

Adverse Childhood Experiences ◽

Externalizing Problems ◽

Anxiety And Depression ◽

Depression And Anxiety ◽

Childhood Experiences ◽

Targeted Interventions ◽

Adverse Childhood ◽

Children’S Behaviour

AbstractAdverse childhood experiences (ACEs) of parents are associated with a variety of negative health outcomes in offspring. Little is known about the mechanisms by which ACEs are transmitted to the next generation. Given that maternal depression and anxiety are related to ACEs and negatively affect children’s behaviour, these exposures may be pathways between maternal ACEs and child psychopathology. Child sex may modify these associations. Our objectives were to determine: (1) the association between ACEs and children’s behaviour, (2) whether maternal symptoms of prenatal and postnatal depression and anxiety mediate the relationship between maternal ACEs and children’s behaviour, and (3) whether these relationships are moderated by child sex. Pearson correlations and latent path analyses were undertaken using data from 907 children and their mothers enrolled the Alberta Pregnancy Outcomes and Nutrition study. Overall, maternal ACEs were associated with symptoms of anxiety and depression during the perinatal period, and externalizing problems in children. Furthermore, we observed indirect associations between maternal ACEs and children’s internalizing and externalizing problems via maternal anxiety and depression. Sex differences were observed, with boys demonstrating greater vulnerability to the indirect effects of maternal ACEs via both anxiety and depression. Findings suggest that maternal mental health may be a mechanism by which maternal early life adversity is transmitted to children, especially boys. Further research is needed to determine if targeted interventions with women who have both high ACEs and mental health problems can prevent or ameliorate the effects of ACEs on children’s behavioural psychopathology.

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Maternal depression in early childhood and child emotional and behavioral outcomes at school age: examining the roles of preschool childcare quality and current maternal depression symptomatology

European Child & Adolescent Psychiatry ◽

10.1007/s00787-019-01385-7 ◽

2019 ◽

Vol 29 (5) ◽

pp. 637-648 ◽

Cited By ~ 2

Author(s):

Justine Charrois ◽

Sylvana M. Côté ◽

Stéphane Paquin ◽

Jean R. Séguin ◽

Christa Japel ◽

...

Keyword(s):

Early Childhood ◽

Maternal Depression ◽

Behavioral Outcomes ◽

School Age ◽

Childcare Quality ◽

Depression Symptomatology ◽

Preschool Childcare

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Maternal Depression Affects Infants’ Lexical Processing Abilities in the Second Year of Life

Brain Sciences ◽

10.3390/brainsci10120977 ◽

2020 ◽

Vol 10 (12) ◽

pp. 977

Author(s):

Ruth Brookman ◽

Marina Kalashnikova ◽

Janet Conti ◽

Nan Xu Rattanasone ◽

Kerry-Ann Grant ◽

...

Keyword(s):

Language Development ◽

Maternal Depression ◽

Lexical Processing ◽

Risk Group ◽

Postnatal Period ◽

Adverse Outcomes ◽

Early Years ◽

Depression And Anxiety ◽

Expressive Vocabulary ◽

Processing Abilities

Maternal depression and anxiety have been proposed to increase the risk of adverse outcomes of language development in the early years of life. This study investigated the effects of maternal depression and anxiety on language development using two approaches: (i) a categorical approach that compared lexical abilities in two groups of children, a risk group (mothers with clinical-level symptomatology) and a control non-risk group, and (ii) a continuous approach that assessed the relation between individual mothers’ clinical and subclinical symptomatology and their infants’ lexical abilities. Infants’ lexical abilities were assessed at 18 months of age using an objective lexical processing measure and a parental report of expressive vocabulary. Infants in the risk group exhibited lower lexical processing abilities compared to controls, and maternal depression scores were negatively correlated to infants’ lexical processing and vocabulary measures. Furthermore, maternal depression (not anxiety) explained the variance in infants’ individual lexical processing performance above the variance explained by their individual expressive vocabulary size. These results suggest that significant differences are emerging in 18-month-old infants’ lexical processing abilities, and this appears to be related, in part, to their mothers’ depression and anxiety symptomatology during the postnatal period.

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