39. CHRONIC STRESS REGULATION OF SPLICEOSOME-ASSOCIATED PROTEIN CWC22 MODULATES HIPPOCAMPAL NEURONAL STRUCTURE AND FUNCTION

Alzheimer’s disease, a neurodegenerative disease, is one of the most common causes of dementia if elderly people worldwide. Alzheimer’s disease leads to the alienation of individuals and their exclusion from social and professional life. It is characterized mainly by the degradation of memory and disorientation, which occurs as a result of the loss of neuronal structure and function in different brain areas. In recent years, more and more attention has been paid to use in the treatment of natural bioactive compounds that will be effective in neurodegenerative diseases, including Alzheimer’s disease. G. biloba L. and its most frequently used standardized extract (EGb 761), have been used for many years in supportive therapy and in the prevention of cognitive disorders. The paper presents an overview of reports on the pathogenesis of Alzheimer’s disease, as well as a summary of the properties of G. biloba extract and its effects on the possible pathogenesis of the disease. By exploring more about the pathogenesis of the disease and the benefits of G. biloba extract for patients with Alzheimer’s disease, it will be possible to create an individualized therapeutic protocol to optimize the treatment.

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Review on various factors responsible for neurodegenerative disorders

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.16.1.0203 ◽

2021 ◽

Vol 16 (1) ◽

pp. 126-132

Author(s):

Harshwardhan J Tembhurnikar ◽

Neha D Thool ◽

Rasika J Patil ◽

Ranjita K Das

Keyword(s):

Oxidative Stress ◽

Nervous System ◽

Neurodegenerative Disorders ◽

Protein Misfolding ◽

Critical Role ◽

Structure And Function ◽

Neuronal Structure ◽

Pathophysiological Mechanisms ◽

Neurological Illnesses ◽

And Function

Neurodegenerative disorders are nervous system disorders that result in the loss of neuronal structure and function. As shown in Alzheimer's and Parkinson's disease, these changes cause a loss of various capacities, including cognition and mobility. Several factors have been discovered to play a critical role in the etiology of common neurological illnesses, including oxidative stress and protein misfolding. It's still unclear if these factors cause or contribute to the progression of the illnesses. Despite efforts to understand the molecular and pathophysiological mechanisms behind these pathways, many aspects remain unknown. The goal of this review is to investigate the numerous factors linked to neurodegeneration.

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Neuronal growth and target recognition: lessons from the leech

Canadian Journal of Zoology ◽

10.1139/z00-198 ◽

2001 ◽

Vol 79 (2) ◽

pp. 204-217 ◽

Cited By ~ 2

Author(s):

Michael W Baker ◽

Eduardo R Macagno

Keyword(s):

Nervous System ◽

Target Recognition ◽

Structure And Function ◽

Neuronal Structure ◽

Peripheral Neurons ◽

Unique System ◽

Molecular Studies ◽

The Subject ◽

The 1960S ◽

And Function

The nervous system of the leech has been the subject of numerous studies since its "rediscovery" in the 1960s as a unique system for the study of the properties of glial cells. Subsequently, anatomical, physiological, and embryological studies of identified neurons have yielded a wealth of information about the differentiation of neuronal structure and function. In recent years, cellular approaches to the development of identified central and peripheral neurons have been complemented by molecular studies that promise to reveal the mechanisms by which neurons form their complex arbors and innervate specific targets.

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Infrared videomicroscopy: a new look at neuronal structure and function

Trends in Neurosciences ◽

10.1016/0166-2236(94)90130-9 ◽

1994 ◽

Vol 17 (11) ◽

pp. 453-458 ◽

Cited By ~ 79

Author(s):

Hans-Ulrich Dodt ◽

Walter Zieglga¨nsberger

Keyword(s):

Structure And Function ◽

Neuronal Structure ◽

And Function ◽

New Look

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[P199]: Regulation of neuronal structure and function by mTOR-dependent and -independent signaling pathways

International Journal of Developmental Neuroscience ◽

10.1016/j.ijdevneu.2006.09.259 ◽

2006 ◽

Vol 24 (8) ◽

pp. 581-581

Author(s):

G. Wu ◽

C. Long ◽

V. Kumar ◽

J. Levenson ◽

M. Swank ◽

...

Keyword(s):

Signaling Pathways ◽

Structure And Function ◽

Neuronal Structure ◽

And Function

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Ganoderma Lucidum Modulates Neuronal Structure and Function Regulatory Protein Expression and Protein-protein Interaction in Alzheimer’s Disease Model Animals

10.21203/rs.3.rs-104135/v1 ◽

2020 ◽

Author(s):

Mohammad Rahman ◽

Shahdat Hossain ◽

Noorlidah Abdullah ◽

Norhaniza Aminudin

Keyword(s):

Protein Expression ◽

Ganoderma Lucidum ◽

Structure And Function ◽

Protein Quantification ◽

Hot Water ◽

Differentially Expressed ◽

Male Rats ◽

Neuronal Structure ◽

Altered Expression ◽

And Function

Abstract BackgroundAlzheimer’s disease (AD) is the leading neurodegenerative disorder affecting memory, learning and behavior. Altered expression of proteins involved in neuronal structure and function is a recent observation of AD pathogenesis. Modulation of altered protein expression seems promising in AD therapeutics. In the present experiment, AD ameliorating effect of medicinal mushroom Ganoderma lucidum had been evaluated through its effect on neuronal structure and function related protein expression pattern in AD model rats.MethodsWistar male rats (120 ± 5 gm) were divided into three groups: control (C), AD (A) and G. lucidum hot water extract (HWE) fed AD (AE), each group containing 15 rats. AD model rats were prepared by infusing Aβ1-42 (ab120959, abcam, USA) into the cerebral ventricles. Protein extraction from the brain samples was performed following homogenization of the hippocampus (50 mg ) with lysis buffer (1ml) using a homogenizer (Polytron PT 1200, Kinematica). Protein separation through SDS-PAGE and protein quantification through LC-chip MS/MS Q-TOF had been performed for label-free relative quantification. For statistical analyses, the data were exported to the Mass Profiler Professional (MPP) software and ANOVA (P<0.05) had been performed to overcome the complications of false discovery associated with multiple test analyses. Functional interaction networks of the proteins were identified using the STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) database (version 10.0; http://string-db.org/). For further identifying over-representing pathways and biological functions, the ingenuity pathway analysis (IPA), build version: 389077M, content version: 27821452, (Release date: 2016-06-14) was used (https://www.ingenuity.com/wp-content/themes/ingenuity-qiagen). Datasets of the proteins significantly expressed (P<0.05) and having log fold change of 1.5 and higher were uploaded (AD versus C, AD versus AE and C versus AE). ResultsAmong 2,212 proteins identified in the present study, 819 had been found to be differentially expressed. Of the differentially expressed ones, 40 proteins linked with neuronal structure and function regulation had been observed in the present study. AD rats manifested altered expression of proteins associated with neuronal structure and function. G. lucidum hot water treatment ameliorated the altered expression of those proteins.ConclusionsAltered expression of hippocampal proteins is a hallmark of AD. Neuroproteomics regulatory approach towards AD amelioration seems promising. Inclusion of G. lucidum for proteomics based AD therapeutics in regulation of the proteins involved in neuronal structure and function seem apt. Thus, G. lucidum could be considered as an AD therapeutic agent.

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