P.0378 Pharmacological treatment for type i bipolar disorder in late life – a retrospective analysis

Objective: Neuroserpin is a serine protease inhibitor predominantly expressed in the nervous system functioning mainly in neuronal migration and axonal growth. Neuroprotective effects of neuroserpin were shown in animal models of stroke, brain, and spinal cord injury. Postmortem studies confirmed the involvement of neuroserpin in Alzheimer’s disease. Since altered adult neurogenesis was postulated as an aetiological mechanism for bipolar disorder, the possible effect of neuroserpin gene expression in the disorder was evaluated. Methods: Neuroserpin mRNA expression levels were examined in the peripheral blood of bipolar disorder type I manic and euthymic patients and healthy controls using the polymerase chain reaction method. The sample comprised of 60 physically healthy, middle-aged men as participants who had no substance use disorder. Results: The gene expression levels of neuroserpin were found lower in the bipolar disorder patients than the healthy controls (p=0.000). The neuroserpin levels did not differ between mania and euthymia (both 96% down-regulated compared to the controls). Conclusion: Since we detected differences between the patients and the controls, not the disease states, the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself.

Download Full-text

Gender Disparity in Bipolar Disorder Diagnosis in the United States: A Retrospective Analysis of the 2005‐2017 MarketScan Commercial Claims Database

Bipolar Disorders ◽

10.1111/bdi.13082 ◽

2021 ◽

Author(s):

Guodong Liu ◽

Lan Kong ◽

Ritika Baweja ◽

Djibril Ba ◽

Erika F.H. Saunders

Keyword(s):

United States ◽

Bipolar Disorder ◽

Retrospective Analysis ◽

The United States ◽

Gender Disparity ◽

Claims Database

Download Full-text

The functional impairment of different subtypes and occupational states in euthymic patients with bipolar disorder

BMC Psychiatry ◽

10.1186/s12888-021-03242-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xinyu Liu ◽

Xiaojuan Ma ◽

Wenchen Wang ◽

Jian Zhang ◽

Xia Sun ◽

...

Keyword(s):

Bipolar Disorder ◽

Social Functioning ◽

Rating Scale ◽

Verbal Learning ◽

Occupational Status ◽

Learning Performance ◽

Neurocognitive Functioning ◽

Type I ◽

Speed Of Processing ◽

Occupational Functioning

Abstract Background The aim was to explore the associations between clinical symptoms, demographic variables, social and neurocognitive functioning in euthymic patients with bipolar disorder (BD) stratified by subgroups of DSM-IV BD (type I (BD-I) and type II (BD-II)) and occupational status (employed/unemployed), and to highlight the significance of occupational status when assessing social and neurocognitive functioning in euthymic BD patients. Methods A total of 81 euthymic BD patients were participated in the study. The severity of the depressive and manic/hypomanic symptoms was measured using the 17-item Hamilton Depression Rating Scale (HDRS-17) and the Young Mania Rating Scale (YMRS), respectively. Social functioning and neurocognitive functioning were evaluated by the Functioning Assessment Short Test (FAST) and neurocognitive measures, respectively. Results Employed BD patients displayed greater social functioning (autonomy, occupational functioning, interpersonal relationship domain) and better verbal learning performance and speed of processing than unemployed BD patients. The correlation between neurocognitive functioning and social functioning was stronger in the employed group than in the unemployed group. There were no significant differences in neurocognitive and social functioning between the BD-I and BD-II groups, and the correlation between neurocognitive functioning and social functioning was similar between the BD-I and BD-II groups. Conclusion Employed BD patients may present greater occupational functioning and interpersonal relationships, as well as better verbal learning performance and speed of processing.

Download Full-text