Blood Type and Bipolar Disorder

2002 ◽  
Vol 95 (3) ◽  
pp. 988-988
Author(s):  
Tamas Zonda ◽  
David Lester
Keyword(s):  
Bipolar Disorder ◽  
Blood Type ◽  
Type I ◽  
Type Ii ◽  
Bipolar Patients

Type I bipolar patients in Budapest were reported to have type O blood more often and types A and B blood less often than Type II bipolar patients.

Abnormal white matter integrity as a structural endophenotype for bipolar disorder

2016 ◽  
Vol 46 (7) ◽  
pp. 1547-1558 ◽  
Author(s):  
A. Sarıçiçek ◽  
N. Zorlu ◽  
N. Yalın ◽  
C. Hıdıroğlu ◽  
B. Çavuşoğlu ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Clinical State ◽  
Control Group ◽  
Type I ◽  
Healthy Controls ◽  
Corona Radiata ◽  
Left Posterior ◽  
Axis I ◽  
Bipolar Patients

BackgroundSeveral lines of evidence suggest that bipolar disorder (BD) is associated with white matter (WM) pathology. Investigation of unaffected first-degree relatives of BD patients may help to distinguish structural biomarkers of genetic risk without the confounding effects of burden of illness, medication or clinical state. In the present study, we applied tract-based spatial statistics to study WM changes in patients with BD, unaffected siblings and controls.MethodA total of 27 euthymic patients with BD type I, 20 unaffected siblings of bipolar patients and 29 healthy controls who did not have any current or past diagnosis of Axis I psychiatric disorders were enrolled in the study.ResultsFractional anisotropy (FA) was significantly lower in BD patients than in the control group in the corpus callosum, fornix, bilateral superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, posterior thalamic radiation, cingulum, uncinate fasciculus, superior corona radiata, anterior corona radiata and left external capsule. In region-of-interest (ROI) analyses, we found that both unaffected siblings and bipolar patients had significantly reduced FA in the left posterior thalamic radiation, the left sagittal stratum, and the fornix compared with healthy controls. Average FA for unaffected siblings was intermediate between the healthy controls and bipolar patients within these ROIs.ConclusionsDecreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.

scholarly journals Cognitive dysfunction is worse among pediatric patients with bipolar disorder Type I than Type II

2012 ◽  
Vol 53 (7) ◽  
pp. 775-781 ◽  
Author(s):  
Lindsay S. Schenkel ◽  
Amy E. West ◽  
Rachel Jacobs ◽  
John A. Sweeney ◽  
Mani N. Pavuluri
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Dysfunction ◽  
Pediatric Patients ◽  
Type I ◽  
Type Ii ◽  
Disorder Type

Subthreshold Manifestations of Bipolar Disorders as Health Care’s tool

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Mazza ◽  
D. Harnic ◽  
G. Marano ◽  
V. Catalano ◽  
L. Janiri ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Bipolar Disorders ◽  
Unipolar Depression ◽  
Response To Treatment ◽  
Type I ◽  
Male Patients ◽  
Bipolar Patients ◽  
Disorder Type

Introdution:Our study represents a pilot evaluation about how the MOOD-SR recognizes subthreshold manifestations that may be associated with clinical symptomatology in a group of bipolar patients.Methods:At Day Hospital of Psychiatry, Policlinico “A. Gemelli”, Bipolar Disorders Unit, it has been conducted an experimental study on a heterogeneous sample of 24 patients with a diagnosis of Bipolar Disorder type I. Patients have been assessed with the MOOD-SR, a clinical self-reported interview, that is specific for the spectrum of subthreshold pathology, and with the Quality of Life (QoL), that investigates the patient's quality of life.Results:We have found that 16 patients on 24 report a score higher than 60 (68,4%). Among these, 10 female patients on 15 have a total score higer than 61 (68.75%) while 6 male patients on 9 obtain a total score higher than 60 (62,5%). However, these results have only preliminary value, further studies are needed in order to obtain a deeper evaluation.Conclusion:Spectrum manifestations are both indicator of course and response to treatment and predictive for relapse. This finding may represent an important preventive instrument for maniacal relapse in patients with Bipolar Disorder, that is often underdiagnosed or confused for Unipolar Depression. By adequately recognizing the problem we will be able to refine diagnosis and individualize therapy.

scholarly journals The Interaction of the Oxytocin Receptor Gene and Subtypes of Child Abuse on Social Cognition in Euthymic Patients With Bipolar Disorder Type I

2020 ◽  
Author(s):  
Ulises Rios ◽  
Javier Moran ◽  
Jimena Hermosilla ◽  
Rene Gonzalez ◽  
Paulina Muñoz ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Child Abuse ◽  
Social Cognition ◽  
High Frequency ◽  
Oxytocin Receptor ◽  
Clinical Group ◽  
Type I ◽  
Environment Interaction ◽  
Early Stress ◽  
Bipolar Patients

Abstract Background: Most studies on cognitive impairment in Bipolar Disorder (BD) have neglected the role of early stress, despite the high frequency of childhood maltreatment in this clinical group. The aim of this study was to establish a connection between a history of emotional, physical, and sexual abuse in childhood and social cognition (SC) functioning in patients with BD type I in euthymia, and to test a possible moderating effect of the polymorphism rs53576 in the oxytocin receptor (OXTR) gene. Results: We found a high frequency of child abuse, indicating that BD patients who had been victims of physical and emotional abuse as children, and were carriers of the GG genotype at OXTR rs53576, displayed higher social cognition alterations, specifically in an emotion recognition test. Conclusions: The gene-environment interaction study presented here proposes a Differential Susceptibility model of a genetic polymorphism that can be plausibly associated with SC functioning. This evidence might help to identify at-risk clinical subgroups within a diagnostic category with well-established intra-group heterogeneity such as BD. Future research aimed at testing the inter-level impact of early stress constitutes an ethical-clinical duty in light of the high rates of childhood abuse reported in bipolar patients.

Bipolar Disorder and Cannabis

2017 ◽  
Vol 41 (S1) ◽  
pp. S118-S119
Author(s):  
G. Jmii ◽  
M. Zghal ◽  
F. Ghali ◽  
M. Mezghenni ◽  
L. Jouini ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Substance Dependence ◽  
Suicide Attempts ◽  
Bipolar Disorders ◽  
Cross Sectional Study ◽  
Cannabis Use ◽  
Type I ◽  
Cross Sectional ◽  
Average Hospital ◽  
Bipolar Patients

IntroductionPeople with bipolar disorder frequently struggle with substance abuse and dependence. Typically, cannabis is the most commonly abused drug in individuals with bipolar disorder. Some investigators have implied that cannabis may actually be mood stabilizing in patients with bipolar disorder. However, the relationships between cannabis use and bipolar disorders are complex and remain incompletely described.ObjectiveThe aim of this study was to identify the characteristics of addiction to cannabis in bipolar patients type I and determine the consequences of cannabis on the expression of bipolar illness and prognosis.MethodsThis is a comparative cross-sectional study which included patients followed in the psychiatry department of the G Razi hospital for bipolar disorder type I and for substance dependence according to DSM IV diagnostic criteria. Hetero-questionnaire on sociodemographic variables, clinical and treatment.ResultsThe average age was 41 years. The average hospital stay was 9.18 days. 33.33% of patients were monitored regularly. Most patients were single and worked as a day labourer. Cannabis was the most consumed substance. Cannabis use was prior to the expression of psychiatric illness in 55% of cases. The average number of hospitalisation in patients with a cannabis addiction was significantly greater than that observed in the non-addicted group. Similarly, the average number of suicide attempts among patients with cannabis addiction was significantly higher than the group without cannabis addiction.ConclusionsAggressive drug abuse treatment immediately after a first psychiatric hospitalisation might decrease rates of recurrence and new cases of cannabis use disorder in the course of bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Childhood traumatic experiences of patients with bipolar disorder type I and type II

2015 ◽  
Vol 175 ◽  
pp. 92-97 ◽  
Author(s):  
Delfina Janiri ◽  
Gabriele Sani ◽  
Emanuela Danese ◽  
Alessio Simonetti ◽  
Elisa Ambrosi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Traumatic Experiences ◽  
Type I ◽  
Type Ii ◽  
Disorder Type

Impulsivity and Brain Volume in Patients with Bipolar Disorder type I and Bipolar Disorder Type II

2017 ◽  
Vol 41 (S1) ◽  
pp. S75-S75
Author(s):  
D. Janiri ◽  
G. Giuseppin ◽  
E. Spinazzola ◽  
M. Maggiora ◽  
G. Sani
Keyword(s):  
Bipolar Disorder ◽  
Negative Relationship ◽  
Statistical Parametric Mapping ◽  
Angular Gyrus ◽  
Type I ◽  
Type Ii ◽  
Brain Volumes ◽  
Competing Interest ◽  
The Right ◽  
Disorder Type

IntroductionImpulsivity is a key feature of both bipolar disorder (BD) type I (BDI) and type II (BDII).ObjectiveStructural neuroimaging studies help clarifying brain mechanisms underpinning the regulation of impulsivity in BDI and BDII.AimsTo address the question whether grey matter (GM) alterations relate differently with impulsivity in BDI and BDII.MethodsWe assessed 54 euthymic outpatients, diagnosed with BDI (n = 28) or BDII (n = 26) according to DSM-IV-TR criteria. They underwent a 3 T magnetic resonance imaging (MRI) investigation. GM brain volumes were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping 8. The Barratt Impulsiveness Scale (BIS), version 11A, was used to assess trait impulsivity.ResultsBDI and BDII patients present an inverse relationship between impulsivity and GM volume in two cerebral areas: the right cerebellum (right crus I) and the interface between the left angular gyrus and the left inferior parietal cortex (Brodmann Area 39, 7, 40). More specifically, a negative relationship for BPI and a positive relationship for BPII were found in both areas.ConclusionsResults suggest that the different diagnosis between BDI and BDII could have a significant effect on GM changes according to impulsivity severity and point up the importance of considering the BP subtype distinction in neuroimaging studies on this topic.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls

2018 ◽  
Vol 213 (3) ◽  
pp. 548-554 ◽  
Author(s):  
Sonya F. Foley ◽  
Matthew Bracher-Smith ◽  
Katherine E. Tansey ◽  
Judith R. Harrison ◽  
Greg D. Parker ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Fractional Anisotropy ◽  
Type I ◽  
Healthy Controls ◽  
Type Ii ◽  
Uncinate Fasciculus ◽  
Polygenic Risk ◽  
The Right ◽  
Main Effects ◽  
Disorder Type

BackgroundFractional anisotropy in the uncinate fasciculus and the cingulum may be biomarkers for bipolar disorder and may even be distinctly affected in different subtypes of bipolar disorder, an area in need of further research.AimsThis study aims to establish if fractional anisotropy in the uncinate fasciculus and cingulum shows differences between healthy controls, patients with bipolar disorder type I (BD-I) and type II (BD-II), and their unaffected siblings.MethodFractional anisotropy measures from the uncinate fasciculus, cingulum body and parahippocampal cingulum were compared with tractography methods in 40 healthy controls, 32 patients with BD-I, 34 patients with BD-II, 17 siblings of patients with BD-I and 14 siblings of patients with BD-II.ResultsThe main effects were found in both the right and left uncinate fasciculus, with patients with BD-I showing significantly lower fractional anisotropy than both patients with BD-II and healthy controls. Participants with BD-II did not differ from healthy controls. Siblings showed similar effects in the left uncinate fasciculus. In a subsequent complementary analysis, we investigated the association between fractional anisotropy in the uncinate fasciculus and polygenic risk for bipolar disorder and psychosis in a large cohort (n= 570) of healthy participants. However, we found no significant association.ConclusionsFractional anisotropy in the uncinate fasciculus differs significantly between patients with BD-I and patients with BD-II and healthy controls. This supports the hypothesis of differences in the physiological sub-tract between bipolar disorder subtypes. Similar results were found in unaffected siblings, suggesting the potential for this biomarker to represent an endophenotype for BD-I. However, fractional anisotropy in the uncinate fasciculus seems unrelated to polygenic risk for bipolar disorder or psychosis.Declaration of interestNone.

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