A review about comorbidity between obsessive-compulsive symptoms and huntintong disease and a case report

2017 ◽  
Vol 41 (S1) ◽  
pp. S702-S703
Author(s):  
L. Sánchez Blanco ◽  
M. Juncal Ruíz ◽  
G. Pardo de Santayana Jenaro ◽  
M. Goméz Revuelta ◽  
R. Landera Rodríguez ◽  
...  
Keyword(s):  
Case Report ◽  
Basal Ganglia ◽  
Psychiatric Symptoms ◽  
Therapeutic Option ◽  
Neuropsychiatric Symptoms ◽  
Previous History ◽  
Depressive Mood ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder

IntroductionThe concept of obsessive-compulsive disorder (OCD) as a disorder that affects the basal ganglia arising to the phenomenological similarities found between idiopathic OCD and other conditions associated with basal ganglia disease such as Huntington's disease (HD) and Sydenham's chorea. Huntintong's disease is characterized by cognitive, motor and neuropsychiatric symptoms.AimsA review of articles published from 1989 to 2016 in Pub-Med and UpToDate about relationship between HD and obsessive-compulsive symptoms.MethodsCase report of a 56-year-old male who was admitted at the acute unit of psychiatry with obsessive-compulsive symptoms marked by hypochondriac obsessive thoughts. He also had cleaning rituals in relation with meals and we observed an important functional impairment and depressive mood. No previous history except family chorea without cognitive impairment in study by neurology department.ResultsAffective disorders are the most common psychiatric disorders in HD. Less frequently it can be found other psychiatric symptoms as obsessive-compulsive behaviour with prevalences between 10% to 52%. Psychiatric symptoms do not correlate with duration of disease or presence of dementia or motor symptoms.ConclusionsIt is necessary to complete the study of the patient to provide a more appropriate therapeutic option. The neurological signs of basal ganglia disorder should be evaluated when considering OCD diagnosis, especially in atypical presentation ages. Longitudinal studies are needed to determine the pathogenesis, disease progression and future therapeutic options.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Complex phonic tic and disinhibition in Tourette syndrome: case report

2001 ◽  
Vol 59 (3A) ◽  
pp. 587-589 ◽  
Author(s):  
Débora Palmini Maia ◽  
Francisco Cardoso
Keyword(s):  
Breast Cancer ◽  
Case Report ◽  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Tourette Syndrome ◽  
Limbic Cortex ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Behavioral Abnormalities ◽  
Motor Tics

Tourette syndrome (TS) is a neuropsychiatric disorder characterized by a combination of multiple motor tics and at least one phonic tic. TS patients often have associated behavioral abnormalities such as obsessive compulsive disorder, attention deficit and hyperactive disorder. Coprolalia, defined as emission of obscenities or swearing, is one type of complex vocal tic, present in 8% to 26% of patients. The pathophysiology of coprolalia and other complex phonic tics remains ill-defined. We report a patient whose complex phonic tic was characterized by repetitively saying "breast cancer" on seeing the son of aunt who suffered from this condition. The patient was unable to suppress the tic and did not meet criteria for obsessive compulsive disorder. The phenomenology herein described supports the theory that complex phonic tics result from disinhibition of the loop connecting the basal ganglia with the limbic cortex.

scholarly journals Schizophrenia with Obsessive Compulsive Symptoms: A Case Report

2019 ◽  
Vol 8 (1) ◽  
pp. 66-67
Author(s):  
A Jha ◽  
D Joshi
Keyword(s):  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Poor Response ◽  
Clinical Impact ◽  
Anti Psychotic ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Co Morbidity

Obsessive-compulsive disorder/ symptoms may be co-morbid in schizophrenia. The clinical impact of this co-morbidity is poor response to anti-psychotic medications. We present a case of 35 yr old female who presented with symptoms suggestive of schizophrenia and later co-morbid obsessive symptom responded well to addition of fluoxetine to antipsychotics. This case study reveals that the identification and treatment of OCD in schizophrenia is very crucial for optimistic outcome.

scholarly journals Obsessive Compulsive Disorder in a Woman with Left Basal Ganglia Infarct: A Case Report

1997 ◽  
Vol 10 (2-3) ◽  
pp. 101-103 ◽  
Author(s):  
Faustino Lopez-Rodriguez ◽  
Ibrahim Gunay ◽  
Nancy Glaser
Keyword(s):  
Case Report ◽  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Structural Damage ◽  
Obsessive Compulsive ◽  
Convulsive Disorder ◽  
Compulsive Disorder

This report presents a syndrome resembling obsessive convulsive disorder (OCD) secondary to a stroke in the left basal ganglia. The patient's syndrome is virtually identical to those that have been described in bilateral damage of the basal ganglia. However, the stroke described in this case report is located unilaterally in the left basal ganglia. In addition, experience in treating a patient with OCD induced by structural damage of basal ganglia is presented.

Successful Anterior Capsulotomy in Comorbid Anorexia Nervosa and Obsessive-Compulsive Disorder: Case Report

Neurosurgery ◽  
2011 ◽  
Vol 69 (3) ◽  
pp. E745-E751 ◽  
Author(s):  
Johan Barbier ◽  
Loes Gabriëls ◽  
Koen van Laere ◽  
Bart Nuttin
Keyword(s):  
Anorexia Nervosa ◽  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Therapeutic Option ◽  
Controlled Study ◽  
Obsessive Compulsive ◽  
Eating Pattern ◽  
Compulsive Disorder ◽  
Anterior Capsulotomy

Abstract BACKGROUND AND IMPORTANCE: State-of-the-art treatment of anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) often proves ineffective. Both disorders have common features, and anterior capsulotomy is a last-resort treatment for OCD. We document the effect of bilateral anterior capsulotomy in a patient with comorbid AN and OCD. CLINICAL PRESENTATION: A 38-year-old woman with life-threatening, chronic, treatment-refractory AN and OCD underwent anterior capsulotomy. Psychiatric and neuropsychological evaluations at baseline and at follow-up document the severity and progress of the case. Bilateral anterior capsulotomy resulted in normalization of eating pattern and weight and a significant decrease of food-related and overall obsessive-compulsive symptoms. Psychiatric evaluations and exposure to food cues confirmed the clinical improvement that was evident immediately after surgery and sustained at 3-month follow-up. CONCLUSION: This case report suggests that bilateral anterior capsulotomy can be a therapeutic option for patients with comorbid AN and OCD. However, a well-controlled study is warranted.

scholarly journals The schizo-obsessive disorder: a case report

2016 ◽  
Vol 17 (4) ◽  
pp. 314-318
Author(s):  
Anna Urbańska ◽  
Agnieszka Lis ◽  
Mateusz Sołowiej ◽  
Aneta Perzyńska-Starkiewicz ◽  
Diana Szymczuk ◽  
...  
Keyword(s):  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Response To Treatment ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Symptom Profile ◽  
Insight Into Illness ◽  
Insight Into ◽  
Worse Prognosis

AbstractPurpose: A case of schizophrenia with coexisting obsessive-compulsive symptoms is reported.Case: The frequency of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) occurrence among patients suffering from schizophrenia is considerably higher in comparison to general population. The results of some studies show that schizo-obsessive disorder is characterized by higher intensity of negative and depressive symptoms. Patients with comorbid schizophrenia and obsessive-compulsive disorder show greater level of social dysfunction and they exhibit suicidal behaviours more often than patients diagnosed with schizophrenia. We present a 33-year-old female with obsessive-compulsive symptoms with onset in her early teens with no satisfactory response to treatment, in spite of her good intellect and insight into illness and cooperation.Comment: There is some evidence suggesting that patients with “schizo-obsessive disorder” have a worse prognosis compared to the group of patients suffering only from schizophrenia, but the effect of OCD on schizophrenia symptom profile is unclear.

scholarly journals Obsessive-Compulsive Symptoms as a Manifestation of Homocystinuria

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Vera Froes ◽  
Hugo Afonso ◽  
Zita Gameiro
Keyword(s):  
Plasma Levels ◽  
Metabolic Disorder ◽  
Autosomal Recessive ◽  
Psychiatric Symptoms ◽  
Psychiatric History ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Lack Of Information

Homocystinuria is a rare autosomal recessive metabolic disorder due to a defect in the cystathionine β-synthase (CBS) that leads to high homocysteine plasma levels. Psychiatric symptoms secondary to homocystinuria have been described in the literature; however, there is a lack of information about obsessive-compulsive symptoms correlated to this disorder. We describe the case of a 39 years old man, diagnosed with homocystinuria in childhood, with no previous psychiatric history that presented obsessive-compulsive disorder (OCD) like symptoms, as a manifestation of homocystinuria. This case underlines the importance for a psychiatrist to explore medical nonpsychiatric history, especially when presentation is abrupt, atypical, or in treatment-resistant cases.

scholarly journals Case Report: Treatment of a Comorbid Attention Deficit Hyperactivity Disorder and Obsessive–Compulsive Disorder With Psychostimulants

2021 ◽  
Vol 12 ◽  
Author(s):  
Ezgi Dogan-Sander ◽  
Maria Strauß
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Case Report ◽  
Obsessive Compulsive Disorder ◽  
Attention Deficit ◽  
Adult Adhd ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Hyperactivity Disorder ◽  
The Impact

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common disease in childhood and adolescence. In about 60% of pediatric patients, the symptoms persist into adulthood. Treatment guidelines for adult ADHD patients suggest multimodal therapy consisting of psychostimulants and psychotherapy. Many adult ADHD patients also suffer from psychiatric comorbidities, among others obsessive–compulsive disorder (OCD). The treatment of the comorbidity of ADHD and OCD remains challenging as the literature is sparse. Moreover, the impact of psychostimulants on obsessive–compulsive symptoms is still unclear.Case Presentation: Here, we report on a 33-year-old patient with an OCD who was unable to achieve sufficient remission under long-term guideline-based treatment for OCD. The re-examination of the psychological symptoms revealed the presence of adult ADHD as a comorbid disorder. The patient has already been treated with paroxetine and quetiapine for the OCD. Due to the newly established diagnosis of ADHD, extended-release methylphenidate (ER MPH) was administered in addition to a serotonin reuptake inhibitor. After a dose of 30 mg ER MPH, the patient reported an improvement in both the ADHD and the obsessive–compulsive symptoms. After discharge, the patient reduced ER MPH without consultation with a physician due to subjectively described side effects. The discontinuation of medication led to a renewed increase in ADHD and obsessive–compulsive symptoms. The readjustment to ER MPH in combination with sertraline and quetiapine thereafter led to a significant improvement in the compulsive symptoms again.Conclusion: The present case shows that in ADHD and comorbid obsessive–compulsive disorder, treatment with psychostimulants can improve the obsessive–compulsive symptoms in addition to the ADHD-specific symptoms. To our knowledge, this is only the second case report describing a treatment with ER MPH for an adult patient with OCD and ADHD comorbidity in the literature. Further research, especially randomized controlled trials, is needed to standardize treatment options.

Obsessive-Compulsive Disorder Spectrum as a Scientific “Metaphor”

CNS Spectrums ◽  
2008 ◽  
Vol 13 (S14) ◽  
pp. 6-15 ◽  
Author(s):  
Stefano Pallanti ◽  
Eric Hollander
Keyword(s):  
Anxiety Disorder ◽  
Basal Ganglia ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Symptom Domains ◽  
Obsessive Compulsive Disorders ◽  
Therapy Studies ◽  
Compulsive Disorders

AbstractAs a result of clinical, epidemiological, neuroimaging, and therapy studies that took place in the late 1980s, obsessive-compulsive disorder (OCD) has been well-characterized in the field of anxiety disorders. Other disorders attracted attention for their similarities to OCD, and were located in the orbit of the disorder. OCD has become known as the “primary domain” of a scientific “metaphor” comprising the putative cluster of OCD-related disorders (OCRDs). It is a “paradigm” with which to explore basal ganglia dysfunction. The OCRDs share common phenomenology, comorbidities, lifetime course, demographics, possible genetics, and frontostriatal dysfunction (particularly caudate hyperactivity.) The adoption of this metaphor analogy has proven useful. However, 15 years since its emergence, the spectrum of obsessive-compulsive disorders remains controversial. Questions under debate include whether OCD is a unitary or split condition, whether it is an anxiety disorder, and whether there exists only one spectrum or several possible spectrums. Further work is needed to clarify obsessive-compulsive symptoms, subtypes, and endophenotypes. There is need to integrate existing databases, better define associated symptom domains, and create a more comprehensive endophenotyping protocol for OCRDs. There is also a need to integrate biological and psychological perspectives, concepts, and data to drive this evolution. By increasing research in this field, the OCD spectrum may evolve from a fragmented level of conceptualization as a “metaphor” to one that is more comprehensive and structured.

scholarly journals Pediatric Acute-onset Neuropsychiatric Syndrome and Mycoplasma Pneumoniae Infection: A Case Report Analysis with a Metabolomics Approach

2020 ◽  
Vol 16 (3) ◽  
pp. 183-193 ◽  
Author(s):  
Cristina Piras ◽  
Roberta Pintus ◽  
Dario Pruna ◽  
Angelica Dessì ◽  
Luigi Atzori ◽  
...  
Keyword(s):  
Case Report ◽  
Protein Biosynthesis ◽  
Neuropsychiatric Symptoms ◽  
Acute Onset ◽  
Point Of View ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Before And After ◽  
New Biomarkers ◽  
The Individual

: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is a clinical condition characterized by a sudden and dramatic obsessive-compulsive disorder with a suggested post-infectious immune-mediated etiology. This condition is accompanied by an extensive series of relatively serious neuropsychiatric symptoms. The diagnosis of PANS is made by "exclusion", as the individual PANS symptoms overlap with a multiplicity of psychiatric disorders with the onset in childhood. A number of researchers accumulated evidence to support the hypothesis that PANS was closely associated with a number of infections. : In the last decade, metabolomics played an essential role in improving the knowledge of complex biological systems and identifying potential new biomarkers as indicators of pathological progressions or pharmacologic responses to therapy. The metabolome is considered the most predictive phenotype, capable of recognizing epigenetic differences, reflecting more closely the clinical reality at any given moment and thus providing extremely dynamic data. In the present work, the most recent hypothesis and suggested mechanisms of this condition are reviewed and the case of a 10 - year-old girl with PANS is described, before and after clarithromycin treatment. The main results of this case report are discussed from a metabolomics point of view. The alteration of several metabolic pathways concerning the microbial activity highlights the possible role of the microbiome in the development of PANS. Furthermore, different metabolic perturbations at the level of protein biosynthesis, energy and amino acid metabolisms are observed and discussed. Based on our observations, it is believed that metabolomics is a promising technology to unravel the mysteries of PANS in the near future.

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