Cortisol Awakening Response and Depression in Acute Coronary Syndrome Patients

2017 ◽  
Vol 41 (S1) ◽  
pp. S142-S142
Author(s):  
V.M. Buonomenna ◽  
F. Marciello ◽  
V. Caivano ◽  
G. Cascino ◽  
G. D’Agostino ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Depressive Symptoms ◽  
Hpa Axis ◽  
Depressed Mood ◽  
Cortisol Awakening Response ◽  
Cortisol Secretion ◽  
Coronary Syndrome ◽  
Hpa Axis Activity ◽  
The Relationship

IntroductionAlthough the available evidence strongly supports an association between depression and coronary heart disease (CHD), the possible biological link between these two conditions still remains to be clarified. The hypothalamus-pituitary-adrenal (HPA) axis is the main endogenous system mediating the stress response and changes in cortisol secretion have been associated with depressed mood in patients with CHD. Therefore, the study of the correlation between cortisol levels and depressed mood in acute coronary syndrome (ACS) patients could help to clarify the nature of the relationship between ACS and the risk to develop a depressive syndrome.ObjectiveWe aimed to explore the relationships between HPA axis activity and depressed mood in ACS patients.AimsThe purpose of this study was to determine whether the cortisol awakening response (CAR) is associated and/or predict depressive symptoms in patients with an ACS.MethodPatients admitted to an ACS ward were asked to fill in the Beck Depression Inventory (BDI) and to collect saliva samples in the morning to measure their CAR. All the procedures were carried out within 1 week after an ACS. Patients were asked again to fill in the BDI six months after their ACS.ResultsA lower CAR was associated with higher BDI scores after 6 months from an ACS.ConclusionsOur preliminary results suggest that hypoactivity of the HPA axis in the first week of an ACS may predict more severe depressive symptoms after 6 months from the ACS.

scholarly journals Cortisol levels and history of depression in acute coronary syndrome patients

2012 ◽  
Vol 42 (9) ◽  
pp. 1815-1823 ◽  
Author(s):  
N. Messerli-Bürgy ◽  
G. J. Molloy ◽  
A. Wikman ◽  
L. Perkins-Porras ◽  
G. Randall ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Depressive Symptoms ◽  
Hpa Axis ◽  
Smoking Status ◽  
Cardiac Morbidity ◽  
Coronary Syndrome ◽  
Total Cortisol ◽  
History Of ◽  
Hpa Axis Dysregulation ◽  
History Of Depression

BackgroundDepressed mood following an acute coronary syndrome (ACS) is a risk factor for future cardiac morbidity. Hypothalamic–pituitary–adrenal (HPA) axis dysregulation is associated with depression, and may be a process through which depressive symptoms influence later cardiac health. Additionally, a history of depression predicts depressive symptoms in the weeks following ACS. The purpose of this study was to determine whether a history of depression and/or current depression are associated with the HPA axis dysregulation following ACS.MethodA total of 152 cardiac patients completed a structured diagnostic interview, a standardized depression questionnaire and a cortisol profile over the day, 3 weeks after an ACS. Cortisol was analysed using: the cortisol awakening response (CAR), total cortisol output estimated using the area under the curve method, and the slope of cortisol decline over the day.ResultsTotal cortisol output was positively associated with history of depression, after adjustment for age, gender, marital status, ethnicity, smoking status, body mass index (BMI), Global Registry of Acute Cardiac Events (GRACE) risk score, days in hospital, medication with statins and antiplatelet compounds, and current depression score. Men with clinically diagnosed depression after ACS showed a blunted CAR, but the CAR was not related to a history of depression.ConclusionsPatients with a history of depression showed increased total cortisol output, but this is unlikely to be responsible for associations between depression after ACS and later cardiac morbidity. However, the blunted CAR in patients with severe depression following ACS indicates that HPA dysregulation is present.

The relationship between phobic anxiety and 2-year readmission after Acute Coronary Syndrome: What is the role of heart rate variability?

2019 ◽  
Vol 247 ◽  
pp. 73-80 ◽  
Author(s):  
Adrienne O'Neil ◽  
C. Barr Taylor ◽  
David L. Hare ◽  
Emma Thomas ◽  
Samia R. Toukhsati ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Phobic Anxiety ◽  
The Relationship

scholarly journals Endovascular Treatment with Limus Eluting Stents in Patients with Acute Coronary Syndrome

2019 ◽  
Vol 8 (1) ◽  
pp. 45-52
Author(s):  
M. V. Chernyayev ◽  
A. G. Faybushevich ◽  
Y. S. Muzganova
Keyword(s):  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Drug Therapy ◽  
Fatal Outcome ◽  
Drug Eluting Stent ◽  
Health State ◽  
Medium Term ◽  
Coronary Syndrome ◽  
Drug Eluting

BACKGROUND Coronary heart disease is one of the main causes of the population’s disability and mortality in Russia and abroad. Revascularization with coronary stents in the course of the most suitable drug therapy is one of the most important treatments of coronary heart disease. It is essential to pay special attention to the research results of using modern stents, in particular, the frst Russian drug-eluting stent “CALYPSO”.AIM OF STUDY To study immediate and medium-term results of Limus-eluting stents procedure in patients with acute coronary syndrome.MATERIAL AND METHODS 304 patients with acute coronary syndrome were included into the research and were divided into 2 groups. The frst group consisted of 156 patients with CALYPSO stent (Angioline, Russia). The other group consisted of 148 patients who had undergone revascularization with the XIENCE stent (Abbot Vascular, USA). Their health state was monitored via phone 3, 6, 9 and 12 months later. After the discharge from the hospital, the drug therapy was prescribed, and instrumental procedures of diagnostics were planned for the period of 9–12 months. According to the results of the examination, patients with suspected or confrmed myocardial ischemia underwent follow-up coronary angiography.RESULTS The success of implantation was 98.63% in the frst group, and 99.4% in the second group. One fatal outcome occurred in both groups during hospitalization (thus making 0.64% и 0.67%). The placement of the CALYPSO stent in distal parts of coronary arteries requested signifcantly less time and contrast. Medium-term results of stenting in both groups appeared to be comparable (thus, all cause death 3 (1.92%) and 2 (1.35%), restenosis >50% 3 (1.92%) and 3 (2 %), late thrombosis — 0 in both groups, cardiac death — 0 in both groups. End points (MACE) in both groups were 1.28% and 0.67%.CONCLUSION Taking into consideration immediate and medium-term results it can be concluded that domestic stents (CALYPSO) are comparable to stents XIENCE. The CALYPSO stent is more advantageous than the XIENCE in the delivery to the lesion focus while performing the procedure in distal flow.

scholarly journals The relationship of MicroRNA-21 and plaque stability in acute coronary syndrome

Medicine ◽  
2019 ◽  
Vol 98 (47) ◽  
pp. e18049
Author(s):  
Wangwei He ◽  
Liyuan Zhu ◽  
Yu Huang ◽  
Yinfen Zhang ◽  
Weimin Shen ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Plaque Stability ◽  
Coronary Syndrome ◽  
Relationship Of ◽  
The Relationship
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