Subchronic oral toxicity of a standardized white kidney bean (Phaseolus vulgaris) extract in rats

2007 ◽  
Vol 45 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Dilip Chokshi
Keyword(s):  
Phaseolus Vulgaris ◽  
Kidney Bean ◽  
Oral Toxicity

Toxicity Studies of Blockal, a Dietary Supplement Containing Phase 2 Starch Neutralizer (Phase 2), a Standardized Extract of the Common White Kidney Bean (Phaseolus vulgaris)

2006 ◽  
Vol 25 (5) ◽  
pp. 361-371 ◽  
Author(s):  
Dilip Chokshi
Keyword(s):  
Phaseolus Vulgaris ◽  
Dietary Supplement ◽  
Digestive Enzyme ◽  
Kidney Bean ◽  
Phase 2 ◽  
Main Ingredient ◽  
Oral Toxicity ◽  
Toxicity Studies ◽  
Effect Level ◽  
The Common

The number of available dietary supplements containing “starch blockers” intended for weight loss has risen dramatically in recent years. These supplements are believed to reduce carbohydrate-derived calories by interfering with α-amylase, the digestive enzyme responsible for conversion of complex carbohydrates to simple absorbable sugars. The present paper reports the findings of single- and multiple-dose (4-week) oral toxicity studies in rats of the marketed dietary supplement Blockal. Blockal contains as its main ingredient Phase 2 Starch Neutralizer (Phase 2 or Phaseolamin 2250), a standardized extract derived from the common white kidney bean ( Phaseolus vulgaris) that has been shown to have α-amylase-inhibiting activity. The Blockal acute oral LD50 exceeded the highest dose tested (3 g/kg body weight [bw]), which provided a single dose of 1668 mg/kg bw of Phase 2 white kidney bean extract. The no-observed-effect level (NOEL) seen in the 4-week study was equivalent to the highest Blockal dose tested (2 g/kg bw/day), which provided 1112 mg/kg/day of Phase 2 white kidney bean extract. The results of these studies support and are consistent with the safety of the marketed dietary supplement Blockal, and indirectly, the safety of its main ingredient, Phase 2 Starch Neutralizer (Phase 2 or Phaseolamin 2250), a standardized extract derived from the common white kidney bean.

scholarly journals Subchronic Study of a White Kidney Bean (Phaseolus vulgaris) Extract with α-Amylase Inhibitory Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Guangqiu Qin ◽  
Fang Wang ◽  
Huili Liang ◽  
Song Tang ◽  
Kamran Shekh ◽  
...  
Keyword(s):  
Body Weight ◽  
Phaseolus Vulgaris ◽  
Inhibitory Activity ◽  
Toxicity Study ◽  
Kidney Bean ◽  
Female Rats ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Experimental Conditions ◽  
Male And Female Rats

Common bean extract as a dietary supplement has received increased attention globally owing to its α-amylase inhibitory activity. The objective of this study was to evaluate the toxicity of a white kidney bean (Phaseolus vulgaris) extract by a repeated-dose 90-day subchronic oral toxicity study in Sprague-Dawley rats. In the subchronic toxicity study, 80 rats were orally administrated with white kidney bean extract at doses of 4, 2, and 1 g/kg body weight daily for 90 days. The results showed that the white kidney bean extract at doses up to 4 g/kg/day did not induce significant changes in body weight, organ weight, food consumption, hematology, serum biochemistry, and histopathology in rats, as compared to the control. The no-observed-adverse-effect level (NOAEL) of white kidney bean extract was determined to be >4 g/kg/day for both male and female rats, under the experimental conditions of this study.

Enteral Crude Red Kidney Bean (Phaseolus vulgaris) Lectin – Phytohemagglutinin – Induces Maturational Changes in the Enterocyte Membrane Proteins of Suckling Rats

Neonatology ◽  
2003 ◽  
Vol 84 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Danuta Kruszewska ◽  
Pawel Kiela ◽  
Åsa Ljungh ◽  
Kennedy H. Erlwanger ◽  
Björn R. Weström ◽  
...  
Keyword(s):  
Phaseolus Vulgaris ◽  
Membrane Proteins ◽  
Kidney Bean ◽  
Suckling Rats ◽  
Red Kidney Bean

scholarly journals Allelopathic Interactions of Parthenium hysterophorous with Kidney Bean, Phaseolus vulgaris

2020 ◽  
pp. 25-33
Author(s):  
H. M. Tsingalia ◽  
J. M. Auma
Keyword(s):  
Phaseolus Vulgaris ◽  
Seed Germination ◽  
Leaf Extract ◽  
Shoot Growth ◽  
Combined Treatment ◽  
Kidney Bean ◽  
Root Extract ◽  
Indigenous Species ◽  
Distilled Water ◽  
Leaf Extracts

Allelopathy, an important mechanism in invasive species stems from the lack of coevolved tolerance of indigenous species to novel chemicals released by the invader species. These chemicals are key to successful invasive of species of natural plant communities and ecosystems. This study analyzed the allelopathic effects of the invasive plant, Parthenium hysterophorous on the growth of kidney beans (Phaseolus vulgaris). One hundred and fifty viable kidney bean seeds were washed in distilled water, and transferred in triplicates to pots with wet sterile sand. Ten grams of freshly collected Parthenium leaves and roots were weighed, grounded separately using a mortar and a pestle, mixed with 100 ml of distilled water in a beaker and left for 24 hours in a dark at a room temperature (250C). The aqueous extract filtrates were used in experimental treatments. While untreated (control) seeds germinated on day 4 seeds treated with leaf extract germinated on day 14 and day 9 for the root extract. Leaf extract inhibited germination and sprouting of new leaves more effectively than root extract. Leaves in control seeds appeared on day 1 after germination. In treated seeds, leaves appeared on the 4th day then stagnated until day 15 when more leaves sprouted. Root extract significantly depressed seed germination. The number of new leaves increased significantly in control seedlings compared to the treated ones. Combined root and leaf extracts highly significantly inhibited of seed germination and the number of new leaves. Additionally, combined treatment with root and leaf extracts significantly inhibited shoot growth, and the increase in leaf length and width. A comparison of the effectiveness of the root and leaf extracts showed that leaf extract was more effective in inhibiting shoot growth and leaf width than the root extract.

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