The anticancer effect of protein-extract from Bidens alba in human colorectal carcinoma SW480 cells via the reactive oxidative species- and glutathione depletion-dependent apoptosis

2008 ◽  
Vol 46 (5) ◽  
pp. 1535-1547 ◽  
Author(s):  
Ping-Lin Ong ◽  
Bor-Chun Weng ◽  
Fung-Jou Lu ◽  
Miao-Ling Lin ◽  
Ting-Ting Chang ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Glutathione Depletion ◽  
Reactive Oxidative Species ◽  
Anticancer Effect ◽  
Protein Extract ◽  
Sw480 Cells ◽  
Human Colorectal Carcinoma ◽  
Oxidative Species

scholarly journals Silibinin Suppresses Growth of Human Colorectal Carcinoma SW480 Cells in Culture and Xenograft through Down-regulation of β-Catenin-Dependent Signaling

Neoplasia ◽  
2010 ◽  
Vol 12 (5) ◽  
pp. 415-424 ◽  
Author(s):  
Manjinder Kaur ◽  
Balaiya Velmurugan ◽  
Alpna Tyagi ◽  
Chapla Agarwal ◽  
Rana P. Singh ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Down Regulation ◽  
Cells In Culture ◽  
Sw480 Cells ◽  
Human Colorectal Carcinoma

scholarly journals Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4902
Author(s):  
Yan Li ◽  
Wendi Luo ◽  
Huixia Zhang ◽  
Caiyun Wang ◽  
Caiyuan Yu ◽  
...  
Keyword(s):  
Dna Damage ◽  
Colorectal Carcinoma ◽  
Dna Synthesis ◽  
Topoisomerase I ◽  
De Novo ◽  
Nucleotide Metabolism ◽  
Dependent Manner ◽  
Anticancer Effect ◽  
Nucleotide Synthesis ◽  
Human Colorectal Carcinoma

Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage. Thus, the action of SN38 against cancers could inevitably affect endogenous levels of ribonucleotide (RNs) and deoxyribonucleotide (dRNs) that play critical roles in many biological processes, especially in DNA synthesis and repair. However, the exact impact of SN38 on RNs and dRNs is yet to be fully elucidated. In this study, we evaluated the anticancer effect and associated mechanism of SN38 in human colorectal carcinoma HCT 116 cells. As a result, SN38 could decrease the cell viability and induce DNA damage in a concentration-dependent manner. Furthermore, cell cycle arrest and intracellular nucleotide metabolism were perturbed due to DNA damage response, of which ATP, UTP, dATP, and TTP may be the critical metabolites during the whole process. Combined with the expression of deoxyribonucleoside triphosphates synthesis enzymes, our results demonstrated that the alteration and imbalance of deoxyribonucleoside triphosphates caused by SN38 was mainly due to the de novo nucleotide synthesis at 24 h, and subsequently the salvage pathways at 48 h. The unique features of SN38 suggested that it might be recommended as an effective supplementary drug with an anticancer effect.

Calvatia lilacinaProtein-Extract Induces Apoptosis through Glutathione Depletion in Human Colorectal Carcinoma Cells

2009 ◽  
Vol 57 (4) ◽  
pp. 1579-1588 ◽  
Author(s):  
Jwu-Guh Tsay ◽  
King-Thom Chung ◽  
Chung-Hung Yeh ◽  
Wan-Ling Chen ◽  
Chi-Hung Chen ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Glutathione Depletion ◽  
Human Colorectal Carcinoma

Fatty Acid Profile and In Vitro Anticancer Activity of Two Marine Sponge- Associated Bacteria

2020 ◽  
Vol 16 (9) ◽  
pp. 1273-1280
Author(s):  
Giuseppina Tommonaro ◽  
Ali M. El-Hagrassi ◽  
Walid Fayad ◽  
Carmine Iodice ◽  
Kamel H. Shaker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Colorectal Carcinoma ◽  
Cell Line ◽  
Marine Sponge ◽  
Hct116 Cell ◽  
Associated Bacteria ◽  
Sponge Associated Bacteria ◽  
Human Colorectal Carcinoma

Background: Colorectal cancer represents one of the prominent causes of mortality worldwide in men and women. The objective of this study was to search for new potential anticancer compounds, both in prevention and treatment of colorectal cancer. The anticancer potential of marine bacterial extracts against Human colorectal carcinoma cell line (HCT116) was evaluated as well as the partial identification of bioactive metabolites. Methods: All bacterial extracts were tested for their cytotoxicity against HCT116 cell line by means of MTT assay. The highly cytotoxic dichloromethane extracts of marine sponge-associated bacteria Vibrio sp. and Bacillus sp. were analyzed by GC-MS. Results: Two fractions, Vib3 and Bac3, exhibited a very interesting cytotoxicity against human colorectal carcinoma (HCT116) cell line, with a percentage of cytotoxicity of 96.04 % and 29.48 %, respectively. Discussion: The GC-MS analysis revealed the presence of two major fatty acids, palmitic and oleic acids, in Vib3 fraction and fatty acid esters and phenolic compounds in Bac3 fraction. Conclusion: Based on previous literature, it may be hypothesized that the anticancer activity of bacterial extracts could be, at least partially, to the fatty acids fraction.

scholarly journals Optimization of the human colorectal carcinoma antigen GA733-2 production in tobacco plants

2021 ◽  
Vol 15 (1) ◽  
pp. 55-67
Author(s):  
Se Hee Park ◽  
Kon-Young Ji ◽  
Hyun Min Kim ◽  
Sang Hoon Ma ◽  
Seo Young Park ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tobacco Plants ◽  
Human Colorectal Carcinoma

scholarly journals Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts

1988 ◽  
Vol 57 (3) ◽  
pp. 277-280 ◽  
Author(s):  
R Giavazzi ◽  
A Garofalo ◽  
G Damia ◽  
S Garattini ◽  
M D'Incalci
Keyword(s):  
Acetic Acid ◽  
Colorectal Carcinoma ◽  
Flavone Acetic Acid ◽  
Human Colorectal Carcinoma
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