Is in vitro fertilization the preferred fertility treatment for young women with conservative treatment of endometrial cancer?

2004 ◽  
Vol 82 ◽  
pp. S139
Author(s):  
S.E. Elizur ◽  
M. Beiner ◽  
Y. KorachG. Ben-Baruch ◽  
J. Dor
Keyword(s):  
Endometrial Cancer ◽  
In Vitro Fertilization ◽  
Conservative Treatment ◽  
Young Women ◽  
Fertility Treatment ◽  
Vitro Fertilization

THE RISK OF DEVELOPING GYNECOLOGICAL CANCER IN WOMEN AFTER AN IN VITRO FERTILIZATION PROGRAM

2021 ◽  
pp. 7-13
Author(s):  
Allakhyarov D.Z. ◽  
Petrov Yu.A. ◽  
Palieva N.V.
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Endometrial Cancer ◽  
In Vitro Fertilization ◽  
Gynecological Cancer ◽  
The Body ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Increased Risk

This article presents reviews of literature sources on the issue of assessing the risk of developing gynecological cancer in women after an in vitro fertilization program. Infertility and infertile marriages have now become quite a big problem of modern medicine. Against the background of the unfavorable demographic situation in the Russian Federation, this problem is becoming quite urgent. The main way to solve this situation is assisted reproductive technologies, among which the most common is in vitro fertilization. The in vitro fertilization program is accompanied by a hormonal ovulation stimulation procedure to obtain a female germ cell capable of fertilization. Against the background of the active use of the in vitro fertilization procedure, many patients had concerns related to the risk of developing gynecological cancer after the IVF procedure, which is due to the use of hormonal drugs to stimulate the ovaries. Also of concern is the fact that certain types of cancer, including ovarian cancer, endometrial cancer and breast cancer, are hormone-dependent. In this regard, multiple large-scale studies were conducted, which showed that the risk of developing gynecological cancer is really increased in patients after the in vitro fertilization program. In particular, breast cancer in women after the in vitro fertilization program is more common by 10%, and in women without a history of pregnancy and over the age of 40, it is more common by 31%. The increased risk may be due to age-related vulnerability to the effects of hormones or higher doses of hormones during the IVF procedure. Ovarian cancer and endometrial cancer are also more common in patients after IVF. According to the research results, it is suggested that it is not the IVF procedure itself that causes the development of cancer, but excessive hormonal load of the body, which leads to the launch of carcinogenesis.

scholarly journals The obligate need for accuracy in reporting preclinical studies relevant to clinical trials: autologous germline mitochondrial supplementation for assisted human reproduction as a case study

2020 ◽  
Vol 14 ◽  
pp. 263349412091735
Author(s):  
Jonathan L. Tilly ◽  
Dori C. Woods
Keyword(s):  
Energy Transfer ◽  
In Vitro Fertilization ◽  
Clinical Studies ◽  
Human Reproduction ◽  
Fertility Treatment ◽  
Success Rates ◽  
Vitro Fertilization ◽  
Mouse Study ◽  
Mitochondrial Supplementation

A now large body of work has solidified the central role that mitochondria play in oocyte development, fertilization, and embryogenesis. From these studies, a new technology termed autologous germline mitochondrial energy transfer was developed for improving pregnancy success rates in assisted reproduction. Unlike prior clinical studies that relied on the use of donor, or nonautologous, mitochondria for microinjection into eggs of women with a history of repeated in vitro fertilization failure to enhance pregnancy success, autologous germline mitochondrial energy transfer uses autologous mitochondria collected from oogonial stem cells of the same woman undergoing the fertility treatment. Initial trials of autologous germline mitochondrial energy transfer during - in vitro fertilization at three different sites with a total of 104 patients indicated a benefit of the procedure for improving pregnancy success rates, with the birth of children conceived through the inclusion of autologous germline mitochondrial energy transfer during in vitro fertilization. However, a fourth clinical study, consisting of 57 patients, failed to show a benefit of autologous germline mitochondrial energy transfer– in vitro fertilization versus in vitro fertilization alone for improving cumulative live birth rates. Complicating this area of work further, a recent mouse study, which claimed to test the long-term safety of autologous mitochondrial supplementation during in vitro fertilization, raised concerns over the use of the procedure for reproduction. However, autologous mitochondria were not actually used for preclinical testing in this mouse study. The unwarranted fears that this new study’s erroneous conclusions could cause in women who have become pregnant through the use of autologous germline mitochondrial energy transfer during- in vitro fertilization highlight the critical need for accurate reporting of preclinical work that has immediate bearing on human clinical studies.

Clinical biochemistry of assisted conception

2009 ◽  
Vol 46 (3) ◽  
pp. 197-204
Author(s):  
Rajeev Srivastava ◽  
Vanessa Kay
Keyword(s):  
In Vitro Fertilization ◽  
Clinical Biochemistry ◽  
Intrauterine Insemination ◽  
Test Tube ◽  
Fertility Treatment ◽  
Assisted Conception ◽  
Eligibility Criteria ◽  
Vitro Fertilization

Assisted reproductive technology has shown rapid advancement since the birth of the first ‘test-tube’ baby in Oldham, UK, in 1978. Since April 2005, women between the ages of 23 and 39, who meet the described eligibility criteria, are able to get one free in vitro fertilization cycle funded by the National Health Service. Private treatment costs anything from £4000 to £8000 for a single cycle of treatment. Almost 15% of the couples in UK are affected by fertility problems and undergo detailed investigations before being offered assisted conception. Assisted reproduction is the collective name for treatments designed to lead to conception by means other than sexual intercourse. These include intrauterine insemination, in vitro fertilization, intracytoplasmic sperm injection and gamete donation. This review is intended to summarize the principles of assisted conception and examine the role of the biochemistry laboratory in: (A) the diagnosis and subsequent management of ovulatory disorders; (B) assessing ovarian reserve before initiating fertility treatment and (C) monitoring fertility treatment. It touches on the screening of potential gamete donors and follow-up of children born after assisted conception. This article was prepared at the invitation of the Clinical Sciences Reviews Committee of the Association of Clinical Biochemistry.

Physiological levels of immunoreactive ANH-like peptides in human follicular fluid

1989 ◽  
Vol 121 (4) ◽  
pp. 578-580 ◽  
Author(s):  
J. A. Sundsfjord ◽  
F. Forsdahl ◽  
G. Thibault
Keyword(s):  
Fluid Dynamics ◽  
In Vitro Fertilization ◽  
Young Women ◽  
Follicular Fluid ◽  
Physiological Role ◽  
Plasma Samples ◽  
Human Follicular Fluid ◽  
Vitro Fertilization ◽  
Follicular Maturation

Abstract. The concentrations of immunoreactive C-terminal (ANH-(99-126)) and N-terminal (ANH-(1-98)) portions of pro-ANH were measured in follicular fluid and plasma samples from 9 young women undergoing in vitro fertilization. ANH-(99-126) and ANH-(1-98)-like immunoreactivity levels in plasma were 6.0–25.4 (mean 12.2) pmol/1 and 184–427 (mean 300) pmol/1, respectively, whereas the corresponding levels in follicular fluid were 3.8–8.0 (mean 4.9) pmol/1 and 169–385 (mean 262) pmol/1. The concentrations of both ANH-like peptides were consistently lower (p < 0.01) in the follicular fluid than in the matched plasma samples, but within the variation found in plasma controls. It is concluded that ANH-like peptides in the follicular fluid, whether secreted locally or derived from circulating ANH, might play a physiological role in the biosynthesis of ovarian steroid hormones or follicular maturation and fluid dynamics.

scholarly journals Understanding the Blogging Practices of Women Undergoing In Vitro Fertilization (IVF): A Discourse Analysis of Women’s IVF Blogs

2017 ◽  
Author(s):  
Elizabeth Orr ◽  
Susan Jack ◽  
Wendy Sword ◽  
Sandra Ireland ◽  
Lois Ostolosky
Keyword(s):  
Discourse Analysis ◽  
In Vitro Fertilization ◽  
Positive Impact ◽  
Emotional Health ◽  
Well Being ◽  
Fertility Treatment ◽  
Vitro Fertilization ◽  
The Rich ◽  
The Impact

Infertility and its associated treatments, including in vitro fertilization (IVF), can have a profound impact on the emotional health and well-being of women desiring to become mothers. Researchers have measured the impact of infertility and described the experience of infertility and its treatment, leaving the rich descriptions of the IVF experience as captured in women’s blogs to be explored. This discourse analysis describes the blogging practices of women undergoing IVF, exploring both the content and function of the IVF blog discourse. Data were collected from the text of seven women’s blogs (n=1,149 blog posts) and resulted in four main functions of the discourse: creation of and connection to a community, emotional support, blogging as therapy, and creation of an IVF resource. Findings suggest that blogging can have a positive impact on the psychosocial consequences experienced by women in fertility treatment.

scholarly journals Pyometra in the postpartum: a forgotten complication

2019 ◽  
Vol 8 (7) ◽  
pp. 2923
Author(s):  
Rana A. Choudhary ◽  
Kedar N. Ganla ◽  
Kavita N. Desai ◽  
Priyanka H. Vora
Keyword(s):  
High Risk ◽  
In Vitro Fertilization ◽  
Conservative Treatment ◽  
Postpartum Period ◽  
Thin Endometrium ◽  
Vitro Fertilization ◽  
High Risk Women ◽  
Important Complication

We report a case of 37 years old women who conceived after in vitro fertilization (IVF). Her antenatal course was uneventful. On delivery there was placenta acreta. She later presented in the postpartum period with pyometra. She was managed with conservative treatment. We believe that the placental bed sutures and the sloughing placenta could have led to sterile pyometra in this patient. This rare but important complication need to be kept in mind specially in high risk women with thin endometrium, h/o IVF, cervical encerclage, and placenta acreta.

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