Obesity and elevated follicular fluid (FF) leptin levels negatively correlate with antral follicle count (AFC) and ovarian response in women with diminished ovarian reserve

2011 ◽  
Vol 96 (3) ◽  
pp. S57
Author(s):  
E. Buyuk ◽  
J. Younger ◽  
H.J. Lieman ◽  
S.K. Jindal ◽  
M.J. Charron
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Ovarian Response ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Diminished Ovarian Reserve

scholarly journals Diminished Ovarian Reserve, Causes, Assessment and Management

2013 ◽  
Vol 4 (2) ◽  
pp. 45-55 ◽  
Author(s):  
Mala Arora ◽  
Mandeep Kaur
Keyword(s):  
Ovarian Reserve ◽  
Treatment Options ◽  
Poor Response ◽  
Ovarian Response ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Diminished Ovarian Reserve ◽  
Assisted Hatching ◽  
Ovum Donation ◽  
Antagonist Protocol

ABSTRACT Diminished ovarian reserve predicts diminished ovarian response to stimulation but does not predict cycle fecundity. It has been recently defined by ESHRE, the Bologna's criteria, according to which at least two of the following three features should be present: (1) Age >40 years/any other risk factor for DOR, (2) abnormal ovarian reserve test, i.e. antral follicle count, AMH, (3) poor ovarian response in a previous stimulated cycle, i.e. less than three follicles after standard gonadotropin stimulation. Poor response to maximal stimulation on two previous occasions also defines DOR. The treatment options are limited. Avoiding the GnRH agonist long protocol and stimulation with microdose flare or antagonist protocol yields better results. Adjuvant therapy with LH, DHEAS and growth hormone shows some benefit in improving the oocyte yield. It is advisable to perform ICSI for all obtained oocytes and some advocate assisted hatching. Pregnancy rates are, however, poor and often these patients require ovum donation. Developing tests that will diagnose DOR in a low-risk population will allow women to plan their reproductive careers early. How to cite this article Kaur M, Arora M. Diminished Ovarian Reserve, Causes, Assessment and Management. Int J Infertility Fetal Med 2013;4(2):45-55.

Value of serum and follicular fluid Sirt1,Sirt2 protein levels in predicting the outcome of assisted reproduction

2020 ◽  
Author(s):  
Lingnv Yao ◽  
Wenqin Lin ◽  
Nan Jiang ◽  
Chuyan Li ◽  
Haifeng Cao ◽  
...  
Keyword(s):  
Assisted Reproduction ◽  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Advanced Age ◽  
Control Group ◽  
Age Group ◽  
Protein Levels ◽  
Study Population

Abstract Background: To explore whether serum and follicular fluid Sirt1, Sirt2 can reflect ovarian reserve and predict the outcome of assisted reproduction. Methods: The study population comprised 125 patients , 39 in OPOI（occult form of premature ovarian insufficiency）group, 49 in advanced age group , and 37 in control group. The levels of serum Sirt1, Sirt2 were measured on the 2nd to 5th day of menstruation (bSirt1,bSirt2) and HCG day. Follicular fluid Sirt1 (FFSirt1) and Sirt2 (FFSirt2), were determined on OPU (oocyte pick up) day. Results: The level of FFSirt2 in the advanced age group was significantly lower than those in other two groups. FFSirt 2 and Sirt 2 (HCG day ) were negatively correlated with age (r=-0.35, r=-0.19), but there were no value of them for assessing DOR (diminished ovarian reserve). The level of bSirt2 in (cumulative) pregnant group was significantly higher (r=0.24, P=0.00). Conclusions: This was the first study to show that FFSirt2 and Sirt2 (HCG day) might be negatively correlated with age and antral follicle count (AFC). bSirt2 could predict cumulative pregnancy outcome together with anti-Mullerian hormone (AMH), AFC and age.

Antral Follicle Diameter Variance Within Each Ovary May Be A Predictor For Poor Response In Cases With Normal Ovarian Reserve

2018 ◽  
Vol 126 (08) ◽  
pp. 521-527
Author(s):  
Ilhan Sanverdi ◽  
Enis Ozkaya ◽  
Suna Kucur ◽  
Dilsat Bilen ◽  
Meryem Eken ◽  
...  
Keyword(s):  
Ovarian Reserve ◽  
Poor Response ◽  
Ovarian Response ◽  
Antral Follicle ◽  
Multivariate Regression Analysis ◽  
Antral Follicle Count ◽  
Estradiol Level ◽  
Poor Ovarian Response ◽  
Follicle Diameter ◽  
The Right

Abstract Objectives To determine the predictive value of antral follicle diameter variance within each ovary for ovarian response in cases with normal ovarian reserve tests. Methods This is a prospective observational study. One hundred and thirty nine infertile women who underwent ART in IVF-ICSI unit of Zeynep Kamil women and children’s Health Training and research hospital between January 2017 to June 2017 were recruited. Blood samples were collected on day 2/day 3 for assessment of serum FSH and estradiol. Trans-vaginal sonography was done for antral follicle count. During antral follicle count, in order to determine antral follicle diameter variance, diameters of the largest and smallest follicles were recorded. Variance was calculated by subtracting the smallest diameter from the largest one. Following ovarian stimulation with antagonist protocol, poor response was determined in cases with total oocyte number≤3. Ovarian reserve tests and antral follicle diameter variance were utilized to predict cases with poor response in women with normal ovarian reserve. Results Antral follicle diameter variance both in right (AUC=0.737, P<0.001) and left (AUC=0.651, P<0.05) ovaries significantly predicted poor ovarian response. Variance>3.5 mm was found to have 75% sensitivity to predict poor response. Basal serum FSH with estradiol levels and AFC failed to predict poor response (P>0.05). Other significant predictors for poor response were day 5 estradiol level and estradiol level at trigger day (P<0.05). In multivariate regression analysis, both AFC and antral follicle diameter variance in the right ovary were found to be significantly associated with clinical pregnancy, on the other hand peak estradiol concentration and antral follicle diameter variance in the right ovary were significantly associated with poor response. Conclusion Antral follicle diameter variance may be utilized to predict poor ovarian response in cases with normal ovarian reserve.

scholarly journals THE RATIO AMH/ANTRAL FOLLICLE COUNT VARIES ACCORDING TO THE ETIOLOGIES OF DIMINISHED OVARIAN RESERVE SUGGESTING DIFFERENCES IN FOLLICULAR HEALTH

2021 ◽  
Vol 116 (3) ◽  
pp. e109
Author(s):  
Michael Grynberg ◽  
Ines Sellami ◽  
Alexandra Benoit ◽  
Nathalie Sermondade ◽  
Charlotte Sonigo
Keyword(s):  
Ovarian Reserve ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Diminished Ovarian Reserve

scholarly journals Anti-Mullerian Hormone:Above and Beyond Conventional Ovarian Reserve Markers

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Zehra Jamil ◽  
Syeda Sadia Fatima ◽  
Khalid Ahmed ◽  
Rabia Malik
Keyword(s):  
Ovarian Reserve ◽  
Critical Role ◽  
Ovarian Response ◽  
Antral Follicle ◽  
Gonadal Development ◽  
Antral Follicle Count ◽  
Reproductive Hormones ◽  
Future Research ◽  
Accurate Estimation ◽  
Radiation Induced

Management of ovarian dysfunctions requires accurate estimation of ovarian reserve (OR). Therefore, reproductive hormones and antral follicle count (AFC) are assessed to indicate OR. Serum anti-Mullerian hormone (AMH) is a unique biomarker that has a critical role in folliculogenesis as well as steroidogenesis within ovaries. Secretion from preantral and early antral follicles renders AMH as the earliest marker to show OR decline. In this review we discuss the dynamics of circulating AMH that remarkably vary with sex and age. As it emerges as a marker of gonadal development and reproductive disorders, here we summarize the role of AMH in female reproductive physiology and provide evidence of higher accuracy in predicting ovarian response to stimulation. Further, we attempt to compile potential clinical applications in children and adults. We propose that AMH evaluation has a potential role in effectively monitoring chemotherapy and pelvic radiation induced ovarian toxicity. Furthermore, AMH guided ovarian stimulation can lead to individualization of therapeutic strategies for infertility treatment. However future research on AMH levels within follicular fluid may pave the way to establish it as a marker of “quality” besides “quantity” of the growing follicles.

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