scholarly journals Influence of abstinence period on clinical outcomes in fresh embryo transfer after intracytoplasmic sperm injection

2015 ◽  
Vol 104 (3) ◽  
pp. e292 ◽  
Author(s):  
J. Lee ◽  
J. Cha ◽  
S. Shin ◽  
Y. Kim ◽  
S. Lee ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Embryo Transfer ◽  
Intracytoplasmic Sperm Injection ◽  
Fresh Embryo Transfer ◽  
Abstinence Period

scholarly journals The Effect of Male Sexual Abstinence Periods on the Clinical Outcomes of Fresh Embryo Transfer Cycles Following Assisted Reproductive Technology: A Meta-Analysis

2020 ◽  
Vol 14 (4) ◽  
pp. 155798832093375
Author(s):  
Jinhong Li ◽  
Qingquan Shi ◽  
Xiaohong Li ◽  
Junliang Guo ◽  
Long Zhang ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Assisted Reproductive Technology ◽  
Clinical Outcomes ◽  
Embryo Transfer ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Reproductive Technology ◽  
Sexual Abstinence ◽  
Fresh Embryo Transfer ◽  
Abstinence Period

A sexual abstinence period (SAP) lasting for 2–7 days is recommended before undertaking semen analyses. However, there is no consensus regarding the length of the SAP for couples using assisted reproductive technology (ART). Therefore, a meta-analysis was performed to compare the effect of short SAPs (less than 4 days) and long SAPs (4–7 days) on the clinical outcomes of fresh embryo transfer cycles after ART. A total of four studies were included in the meta-analysis. Although the fertilization rate in short SAP couples was higher than that in long SAP couples, a pooled analysis demonstrated that it was not statistically significant ( p = .09). The implantation rate was, however, significantly higher in short SAP couples ( p = .0001). The pooled analysis revealed that the pregnancy rate was significantly higher in short SAP couples than that in long SAP couples. The overall odds ratio (OR) for the pregnancy rate was 1.44 ( p = .0006). No significant difference in miscarriage rates between the short and long SAP couples was found ( p = .88). The meta-analysis indicates that a shorter abstinence period could result in higher implantation and pregnancy rates for patients undertaking ART treatments.

scholarly journals EMBRYO GLUE AND CLINICAL PREGNANCY RATES IN ICSI EMBRYO TRANSFER CYCLES: A PROSPECTIVE STUDY

2021 ◽  
Vol 7 (4) ◽  
pp. 1-12
Author(s):  
Salwa Fadhil ◽  
Mohammad Selman ◽  
Manal Al-Obaidi
Keyword(s):  
Embryo Transfer ◽  
Intracytoplasmic Sperm Injection ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Fresh Embryo Transfer ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
A Prospective Study ◽  
Medium Group

Purpose: One of the reasons for failed implantation after transferring good quality embryos in an intracytoplasmic sperm injection cycle is the failure of creation a viscid layer between the embryo and the endometrium. Many modifications have been made in embryo transfer medium to improve implantation and increase pregnancy rates such as adding albumin as a source of energy and adding hyaluronic acid in high concentrations such as in Embryo Glue medium: a human embryo transfer medium. To investigate whether the use of Embryo Glue had any effect on clinical pregnancy rates in intracytoplasmic sperm injection-fresh embryo transfer cycles. Methods: A prospective study included one hundred and twenty-eight infertile Iraqi women who were selected and subjected to a stimulation protocol in an intracytoplasmic sperm injection-fresh embryo transfer cycle. All patients were considered to be eligible for embryo transfer (no visible causes could prevent implantation) and only good quality embryos were transferred to them. Those women were divided randomly into two groups according to type of embryo transfer medium: group A: Embryo Glue medium. group B: Conventional medium. Then group A was subdivided according to age into:  AI (34 women with age < 35 years and represented 50.7%) AII (33 women with age ≥ 35 years and represented 49.3%) While group B was subdivided into:  BI (41women with age < 35 years and represented 67.3%)  BII (20 women with age ≥ 35 years and represented 32.7%). Results: Although there was no significant difference between all groups in causes of infertility, the pregnancy rate was significantly higher in subgroup AII (18 pregnant from 33 women) while only 5 patients became pregnant from 20 patients in subgroup BII.  In all women no more than four good quality embryos were transferred, and when total number of transferred embryos was significantly more in group B than group A (P=0.013), the significant increase in pregnancy rates was only observed in subgroup AII (P=0.048). Even though a highly significant difference in number of repeated implantation failure was in group A than group B (P=0.027), the pregnancy rates were significantly higher in group A (P=0.038). Conclusion: This study concluded that using Embryo Glue has a beneficial effect on old women and increase pregnancy rates, also it has a positive effect on pregnancy rates in repeated implantation failure and increases pregnancy rates even if the women is old.

scholarly journals Luteal progesterone level correlated with immunotherapy success of patients with repeated implantation failures

2019 ◽  
Author(s):  
Omar Sefrioui ◽  
Aicha Madkour ◽  
Nouzha Bouamoud ◽  
Ismail Kaarouch ◽  
Brahim Saadani ◽  
...  
Keyword(s):  
Corpus Luteum ◽  
Clinical Outcomes ◽  
Embryo Transfer ◽  
Mononuclear Cells ◽  
Test Group ◽  
Clinical Pregnancy ◽  
Progesterone Level ◽  
Controlled Study ◽  
Fresh Embryo Transfer ◽  
Peripheral Blood Mononuclear

AbstractImmunotherapy using PBMC administration demonstrated relatively its effectiveness to treat RIF patients but it still unclear to explain some miscarriages. Luteal progesterone level (LPL) issued from corpus luteum after embryo implantation stage could be informative basis data to personalize immunotherapy for RIF patients predicting clinical outcomes. This randomized controlled study included 70 patients undergoing ICSI program presenting at least 3 RIF: 39 for Control of untreated patients and 31 for PBMC-test concerning treated patients with immunotherapy. For PBMC-test group, Peripheral Blood Mononuclear Cells (PBMCs) were isolated from patients on ovulation induction day and cultured three days to be administered to intrauterine cavity of patients two days before fresh embryo transfer. LPL was analyzed at day 15 after embryo transfer and clinical outcomes were calculated including implantation, clinical pregnancy and miscarriage rates. Clinical outcomes were doubly improved after immunotherapy including implantation and clinical pregnancy rates comparing Control versus PBMC-test (10% and 21% vs 24% and 45%). In the other hand, this strategy showed an increase over double in LPL (4ng/ml for Control vs 9ng/ml for PBMC-test) while the latter was correlated to clinical pregnancy. Bypassing the effectiveness of this immunotherapy approach for RIF patients, it is directly correlated to LPL proving the interactive reaction between immune profile of the treated patients and progesterone synthesis by corpus luteum.

Sign in / Sign up

Export Citation Format

Share Document