Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes

Background: Abnormalities or damage to the fallopian tube interferes with fertility and is responsible for abnormal implantation (eg, ectopic pregnancy). Obstruction of the distal end of the fallopian tubes results in accumulation of the normally secreted tubal fluid, creating distention of the tube with subsequent damage of the epithelial cilia (hydrosalpinx). Genital Chlamydia trachomatis infection has a worldwide distribution6 and is now recognized as the single most common cause of tubal peritoneal damage. The study explores the relationship between serum chlamydia antibody titres (CATs) and detection of tubal damage in infertile women.Objective: To Evaluation of tubal and peritonial factors in chlamydia positive infertile women by laparoscope.Methodology: The tubal status and pelvic findings in 138 women underwent laparoscopy for infertility were related to CAT, which was measured using the whole-cell inclusion immunofluorescence test. RESULTS: A total of 138 infertile women who underwent laparoscopic investigation for infertility were identified and they were divided in two groups, on the bsis of presence is absence Chlamydia positive (n=69) and Chlamydia Negative (n=69). Demographic status were almost similar between two groups, however service holder was found significantly higher in Chlamydia positive group (17 vs. 7). Tubal block was found in 44(63.7%) in Chlamydia positive and 37(53.6%) in Chlamydia negative. The difference was statistically significant (p<0.01) between two groups. Site of block & hydrosalpinges was almost similar between two groups. POD was completely obliterated in 10(14.5%) in Chlamydia positive and 3(4.3%) in Chlamydia negative. The difference was statistically significant (p<0.05) between two groups.Conclusion: Chlamydia serology is useful mainly as a screening test for the likelihood of tubal damage in infertile women and may facilitate decisions on which women should proceed with further investigations without delay.J Shaheed Suhrawardy Med Coll, December 2015, Vol.7(2); 54-58

Download Full-text

Prevalence of Chlamydia trachomatis immunoglobulin G antibody in infertile women in Calabar

African Journal of Medical and Health Sciences ◽

10.4103/2384-5589.198319 ◽

2016 ◽

Vol 15 (2) ◽

pp. 74

Author(s):

PatienceO Odusolu ◽

EkpoE Edet ◽

CajethanI Emechebe ◽

ThomasU Agan ◽

AndrewE Okpe ◽

...

Keyword(s):

Chlamydia Trachomatis ◽

Immunoglobulin G ◽

Infertile Women

Download Full-text

Assisted fertilization in infertile women with patent Fallopian tubes. A comparison of in-vitro fertilization, gamete intra-Fallopian transfer and tubal embryo stage transfer

Human Reproduction ◽

10.1093/oxfordjournals.humrep.a137086 ◽

1990 ◽

Vol 5 (3) ◽

pp. 266-270 ◽

Cited By ~ 38

Author(s):

Tom Tanbo ◽

Per Olav Dale ◽

Thomas A˚byholm

Keyword(s):

In Vitro Fertilization ◽

Fallopian Tubes ◽

Vitro Fertilization ◽

Infertile Women ◽

Embryo Stage ◽

Assisted Fertilization

Download Full-text

In infertile women, cells from Chlamydia trachomatis infected site release higher levels of interferon-gamma, interleukin-10 and tumor necrosis factor-alpha upon heat shock protein stimulation than fertile women

Reproductive Biology and Endocrinology ◽

10.1186/1477-7827-6-20 ◽

2008 ◽

Vol 6 (1) ◽

pp. 20 ◽

Cited By ~ 22

Author(s):

Pragya Srivastava ◽

Rajneesh Jha ◽

Sylvette Bas ◽

Sudha Salhan ◽

Aruna Mittal

Keyword(s):

Heat Shock ◽

Chlamydia Trachomatis ◽

Tumor Necrosis ◽

Interleukin 10 ◽

Necrosis Factor Alpha ◽

Infertile Women ◽

Factor Alpha ◽

Necrosis Factor ◽

Site Release ◽

Fertile Women

Download Full-text

High Leptin Level Attenuates Embryo Development in Overweight/Obese Infertile Women by Inhibiting Proliferation and Promotes Apoptosis in Granule Cell

Hormone and Metabolic Research ◽

10.1055/s-0043-107617 ◽

2017 ◽

Vol 49 (07) ◽

pp. 534-541 ◽

Cited By ~ 5

Author(s):

Xian-hua Lin ◽

Hui Wang ◽

Dan-dan Wu ◽

Kamran Ullah ◽

Tian-tian Yu ◽

...

Keyword(s):

Embryo Development ◽

Granulosa Cells ◽

Peripheral Blood ◽

Pregnancy Rates ◽

Dependent Manner ◽

Reproductive Outcomes ◽

Ongoing Pregnancy ◽

Infertile Women ◽

Proliferation And Apoptosis

AbstractObesity appears to be associated with female reproductive dysfunction and infertility. Women with obesity undergoing in vitro fertilization (IVF) had poor oocyte quality, decreased embryo development, and poor pregnancy outcome. However, the mechanism linking obesity to poor reproductive outcomes is still unclear. Obesity is frequently accompanied with elevated leptin levels. Here we aimed to evaluate the effect of high leptin level in follicular fluid (FF) on the proliferation and apoptosis in granule cells and correlate these findings with poor reproductive outcomes in infertile women with overweight or obesity who underwent IVF treatment. We investigated clinical and ongoing pregnancy rates in 189 infertile women who underwent IVF. Leptin levels were quantified in peripheral blood and FF as well. In vitro cell model was used to explore the potential effect of high leptin on the proliferation and apoptosis in granulosa cells. Results showed reduced clinical and ongoing pregnancy rates in overweight/obesity women who underwent IVF compared to control with normal BMI. On the other hand, leptin levels presented significant increase in peripheral blood and FF in overweight/obese women. Leptin level in FF was negatively correlated to good quality embryo rate. Importantly, in vitro study showed that leptin inhibited cells proliferation and promoted apoptosis by upregulation of caspase-3 and downregulation of Bcl-2 in granulosa cells in a dose dependent manner. These observations suggest that leptin may acts as a local mediator to attenuate embryo development and reduce fertility in obese patients.

Download Full-text