scholarly journals AUTOMATIC IMAGE SEGMENTATION AND QUANTITATIVE COMPONENT MEASUREMENTS ON HUMAN BLASTOCYST IMAGES USING ARTIFICIAL INTELLIGENCE (AI) IN ASSESSING MORPHOLOGY GRADING AND PREDICTING IMPLANTATION AND LIVE BIRTH OUTCOMES

2020 ◽  
Vol 114 (3) ◽  
pp. e145-e146
Author(s):  
Jason KM. Au ◽  
May Tian ◽  
Reza Moradi ◽  
Parvaneh Saeedi ◽  
Jon C. Havelock
2019 ◽  
Vol 18 (2) ◽  
pp. 204-211 ◽  
Author(s):  
Yasunari Miyagi ◽  
Toshihiro Habara ◽  
Rei Hirata ◽  
Nobuyoshi Hayashi

2021 ◽  
pp. 405-416
Author(s):  
Ariela Marçal Stefanini ◽  
Taylor Oliveira Fidelis ◽  
Gustavo Moreira Penna ◽  
Gabriel Rodrigo Gomes Pessanha ◽  
Reinaldo Antônio Gomes Marques ◽  
...  

2020 ◽  
Vol 35 (12) ◽  
pp. 2850-2859
Author(s):  
Cassandra Roeca ◽  
Rachel L Johnson ◽  
Tracy Truong ◽  
Nichole E Carlson ◽  
Alex J Polotsky

Abstract STUDY QUESTION For donor oocyte recipients, are birth outcomes superior for fresh versus frozen embryos? SUMMARY ANSWER Among fresh donor oocyte recipients, fresh embryos are associated with better birth outcomes when compared with frozen embryos. WHAT IS KNOWN ALREADY Frozen embryo transfer (ET) with vitrification has been associated with improved pregnancy rates, but also increased rates of large for gestational age infants. Donor oocyte recipients represent an attractive biological model to attempt to isolate the impact of embryo cryopreservation on IVF outcomes, yet there is a paucity of studies in this population. STUDY DESIGN, SIZE, DURATION A retrospective cohort of the US national registry, the Society for Assisted Reproductive Technology Clinic Outcome Reporting System, of IVF cycles of women using fresh donor oocytes resulting in ET between 2013 and 2015. Thawed oocytes were excluded. PARTICIPANTS/MATERIALS, SETTINGS, METHODS Good obstetric outcome (GBO), defined as a singleton, term, live birth with appropriate for gestational age birth weight, was the primary outcome measure. Secondary outcomes included live birth, clinical pregnancy, spontaneous abortion, preterm birth, multiple births and gestational age-adjusted weight. Outcomes were modeled using the generalized estimating equation approach. MAIN RESULTS AND THE ROLE OF CHANCE Data are from 25 387 donor oocyte cycles, in which 14 289 were fresh and 11 098 were frozen ETs. A GBO was 27% more likely in fresh ETs (26.3%) compared to frozen (20.9%) (adjusted risk ratio 1.27; 95% confidence interval (CI) 1.21–1.35; P < 0.001). Overall, fresh transfer was more likely to result in a live birth (55.7% versus 39.5%; adjusted risk ratio 1.21; 95% CI 1.18–1.26; P < 0.001). Among singleton births, there was no difference in gestational age-adjusted birth weight between groups. LIMITATION, REASONS FOR CAUTION Our cohort findings contrast with data from autologous oocytes. Prospective studies with this population are warranted. WIDER IMPLICATIONS OF THE FINDINGS Among donor oocyte recipients, fresh ETs may be associated with better birth outcomes. Reassuringly, given its prevalent use, modern embryo cryopreservation does not appear to result in phenotypically larger infants. STUDY FUNDING/COMPETING INTEREST(S) None. TRIAL REGISTRATION NUMBER N/A.


2019 ◽  
Vol 132 (20) ◽  
pp. 2408-2416 ◽  
Author(s):  
Ling-Ling Lei ◽  
Yong-Lian Lan ◽  
Shu-Yu Wang ◽  
Wei Feng ◽  
Zhi-Jin Zhai

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e023529 ◽  
Author(s):  
Enny S Paixão ◽  
Oona M Campbell ◽  
Maria Gloria Teixeira ◽  
Maria CN Costa ◽  
Katie Harron ◽  
...  

ObjectivesDengue is the most common viral mosquito-borne disease, and women of reproductive age who live in or travel to endemic areas are at risk. Little is known about the effects of dengue during pregnancy on birth outcomes. The objective of this study is to examine the effect of maternal dengue severity on live birth outcomes.Design and settingWe conducted a population-based cohort study using routinely collected Brazilian data from 2006 to 2012.ParticipatingWe linked birth registration records and dengue registration records to identify women with and without dengue during pregnancy. Using multinomial logistic regression and Firth method, we estimated risk and ORs for preterm birth (<37 weeks’ gestation), low birth weight (<2500 g) and small for gestational age (<10thcentile). We also investigated the effect of time between the onset of the disease and each outcome.ResultsWe included 16 738 000 live births. Dengue haemorrhagic fever was associated with preterm birth (OR=2.4; 95% CI 1.3 to 4.4) and low birth weight (OR=2.1; 95% CI 1.1 to 4.0), but there was no evidence of effect for small for gestational age (OR=2.1; 95% CI 0.4 to 12.2). The magnitude of the effects was higher in the acute disease period.ConclusionThis study showed an increased risk of adverse birth outcomes in women with severe dengue during pregnancy. Medical intervention to mitigate maternal risk during severe acute dengue episodes may improve outcomes for infants born to exposed mothers.


Author(s):  
Phillip A. Romanski ◽  
Pietro Bortoletto ◽  
Brady Magaoay ◽  
Alice Chung ◽  
Zev Rosenwaks ◽  
...  

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