EFFECTIVENESS OF HYALURONAN GEL, INTRAUTERINE DEVICE AND THEIR COMBINATION FOR PREVENTION ADHESIONS IN PATIENTS AFTER INTRAUTERINE SURGERY: SYSTEMATIC REVIEW AND META-ANALYSIS

2021 ◽  
Vol 116 (3) ◽  
pp. e428
Author(s):  
Laura Pivazyan ◽  
Ara Unanyan ◽  
Ekaterina Krylova ◽  
Lilia Obosyan ◽  
Anatoly Ishchenko
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Intrauterine Device ◽  
Intrauterine Surgery

scholarly journals Evaluating different pain lowering medications during intrauterine device insertion: a systematic review and network meta-analysis

2019 ◽  
Vol 111 (3) ◽  
pp. 553-561.e4 ◽  
Author(s):  
Ahmed Samy ◽  
Ahmed M. Abbas ◽  
Mostafa Mahmoud ◽  
Ayman Taher ◽  
Mohamed Hammam Awad ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Intrauterine Device

scholarly journals Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Author(s):  
Ahmed Abu-Zaid ◽  
Majed S. Alshahrani ◽  
Nisreen A. Albezrah ◽  
Najlaa T. Miski ◽  
Saud A. Aboudi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Patient Satisfaction ◽  
Side Effects ◽  
Pain Relief ◽  
Meta Analysis ◽  
Intrauterine Device ◽  
Cochrane Library ◽  
Pain Patient ◽  
Controlled Trials ◽  
Uterine Perforation

AbstractObjectiveTo investigate the safety and efficacy of vaginal dinoprostone versus placebo in pain relief during intrauterine device (IUD) insertion.DesignSystematic review and meta-analysis of randomized placebo-controlled trials.SettingNot applicable.Patient(s)Women undergoing IUD insertion and receiving vaginal dinoprostone or placebo.Intervention(s)PubMed, Scopus, Web of Science, and Cochrane Library were screened from inception to 01-October-2020, using the following search strategy: (dinoprostone OR cervidil OR prepidil) AND (intrauterine device OR iud).Main outcome measure(s)IUD insertion related pain, patient satisfaction, provider ease of IUD insertion, and side effects.Result(s)Five studies met the study inclusion criteria, comprising 862 patients; equally 431 patients received vaginal dinoprostone and placebo. All studies had an overall low risk of bias. When compared to placebo, dinoprostone significantly correlated with decreased pain at tenaculum placement (SMD=−0.79, 95% CI [−1.43, −0.16], p=0.01), decreased pain at uterine sounding (SMD=−0.88, 95% CI [−1.54, −0.22], p=0.009), decreased pain at IUD insertion (SMD=−1.18, 95% CI [−1.74, −0.61], p<0.001), decreased need for additional analgesia (RR=0.34, 95% CI [0.22, 0.53], p<0.001), increased patient satisfaction (SMD=1.41, 95% CI [0.62, 2.20], p<0.001), and increased provider ease of IUD insertion (SMD=−1.17, 95% CI [−1.62, −0.73], p<0.001). Fever was statistically significantly higher in dinoprostone versus placebo group (RR=3.73, 95% CI [1.47, 9.44], p=0.006). All other side effects—including nausea, vomiting, shivering, diarrhea, abdominal cramps, vasovagal attack, uterine perforation, and postprocedural bleeding—did not substantially differ between both groups.ConclusionsThis first ever meta-analysis advocates that dinoprostone is safe, effective, and yields favorable analgesic outcomes during IUD insertion.

scholarly journals Intrauterine device survival in Iranian women: Systematic review and meta-analysis

2015 ◽  
Vol 4 (2) ◽  
pp. 203
Author(s):  
Narges Motamedi ◽  
Rasool Nouri ◽  
Ziba Farajzadegan ◽  
Maryam Kheyri
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Intrauterine Device ◽  
Iranian Women

P–302 Levonorgestrel-releasing intrauterine device (LNG-IUD) for symptomatic endometriosis following surgery: a Cochrane systematic review

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
T Gibbons ◽  
E Georgiou ◽  
H Al-Inany ◽  
Y Cheong
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Treatment Satisfaction ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Intrauterine Device ◽  
Postoperative Treatment ◽  
Cochrane Systematic Review ◽  
Troublesome Symptom

Abstract Study question Does levonorgestrel-releasing intrauterine device (LNG-IUD) improve post-operative outcomes for endometriosis when compared to other systemic hormonal treatments or no additional treatment? Summary answer We are uncertain whether LNG-IUD has an impact on dysmenorrhoea when compared to no postoperative treatment or post-operative GnRH agonists (GnRH-a). What is known already Endometriosis is a condition characterised by the presence of ectopic deposits of endometrial-like tissue outside the uterus, usually in the pelvis; inducing a chronic inflammatory response which can lead to pelvic pain and infertility. Various treatment options exist including surgical treatment, ovarian suppression therapy, or a combination of these strategies. The impact of laparoscopic treatment on overall pain is uncertain and a significant proportion of women will require further surgery. Therefore, adjuvant medical therapies such as LNG-IUD have been considered to reduce treatment failure and recurrence of symptoms. Study design, size, duration A Cochrane systematic review and meta-analysis was performed. Electronic searches of the Cochrane Gynaecology and Fertility Specialised Register of Controlled Trials, CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL and Epistemonikos were conducted to January 2021 for relevant randomised controlled trials (RCTs). Two independent authors screened studies and extracted data. Risk ratios (RR) were calculated for dichotomous data and standardised mean differences (SMD) for continuous data, with 95% confidence intervals (CI). Heterogeneity was examined via the I² statistic. Participants/materials, setting, methods Participants: women undergoing surgical treatment for endometriosis without hysterectomy Intervention: LNG-IUD insertion within three months of surgery Comparison: No postoperative treatment, placebo IUD or any other systemic treatment Primary outcome: overall pain Secondary outcomes: improvement of the most troublesome symptom, dysmenorrhoea, quality of life, satisfaction with treatment and adverse events. Primary analysis was conducted on data per woman randomised. Main results and the role of chance Four RCTs were included, with a total of 157 women. Five studies are awaiting classification and one is an ongoing study. We corresponded with original study authors to clarify missing outcome data. No studies reported on overall pain or improvement in the most troublesome symptom. We await study author clarification on quality of life and treatment satisfaction data. We are uncertain whether LNG-IUD improves dysmenorrhoea compared to no postoperative treatment at 12 months. Data on this outcome were reported on by 2 RCTs, but were expressed as median and inter-quartile range and so meta-analysis was not possible (RCT 1: delta of median visual analog scale (VAS) 81 versus 50, p = 0.006, n = 55; RCT 2: fall in VAS by 50 (35–65) p = 0.012 versus 30 (25– 40), p = 0.021, n = 40). We are uncertain whether compared to post-operative GnRH-a, LNG-IUD affects rates of dysmenorrhoea at 6 months (VAS SMD 0.79, 95% CI –0.08 to 1.67, p = 0.08, one RCT, n = 22, very low quality evidence). Various adverse events with LNG-IUD were reported including irregular bleeding and weight gain. However, due to a lack of raw data and comparable studies, we were unable to undertake meta-analysis. Limitations, reasons for caution The major limitation of this systematic review was that there were insufficient studies reporting on our prespecified outcomes, including our primary outcome. In addition, the included studies were not all of high quality with limited long-term follow-up. Wider implications of the findings: This systematic review highlights the paucity of RCTs reporting outcomes included in the new core outcome set for endometriosis research. Further high-quality RCTs are needed to assess postoperative adjuvant hormonal therapy and these should prioritise investigating key endometriosis outcomes such as overall pain, quality of life and treatment satisfaction. Trial registration number Not applicable

scholarly journals Intrauterine device use and risk of cervical cancer: a systematic review and meta-analysis

Contraception ◽  
2016 ◽  
Vol 94 (4) ◽  
pp. 431
Author(s):  
MF Natavio ◽  
M Barrett ◽  
T Enebish ◽  
J Perrigo ◽  
J Tobin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cervical Cancer ◽  
Meta Analysis ◽  
Intrauterine Device ◽  
Device Use

The effects of low-ratio n-6/n-3 PUFA on biomarkers of inflammation: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Yali Wei ◽  
Yan Meng ◽  
Na Li ◽  
Qian Wang ◽  
Liyong Chen
Keyword(s):  
Systematic Review ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Meta Analysis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Inflammation Markers ◽  
Pufa Supplementation ◽  
Long Chain

The purpose of the systematic review and meta-analysis was to determine if low-ratio n-6/n-3 long-chain polyunsaturated fatty acid (PUFA) supplementation affects serum inflammation markers based on current studies.

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