PREDICTION OF INTRACYTOPLASMIC SPERM INJECTION CYCLE OUTCOMES USING A MULTIVARIATE SCORING MODEL

Objective: To elucidate the prognostic factors for intracytoplasmic sperm injection cycle cancellation in patients with endometriosis-related infertility. Study Design: This was a retrospective cohort study and conducted at the Assisted Reproductive Technology center of Uludag University School of Medicine, between the years 2011-2017. The electronic database was screened and infertile patients with endometriosis, without male factor infertility, systemic disease, or undefined adnexal mass, and aged <40 were selected. The endometriosis phenotype of all cycles was classified into three subgroups: superficial endometriosis, ovarian endometrioma and deep infiltrating endometriosis. Cycles were divided into two groups: Group I (Cycle Cancellation) vs. Group II (Embryo transferred). Results: Forty-four cycles were canceled and in 178 cycles, the embryo was able to be transferred. When the groups were compared age and day 3 FSH levels were statistically higher, and anti-Mullerian hormone and antral follicle count were statistically lower in Group I. The presence of adenomyosis was higher in Group I (64% vs. 40% p<0.01). The surgery rate with laparotomy was higher in Group I (54.5% vs. 13.5% p<0.01). Antral follicle count remained as the only independent factor associated with prognoses of the IVF cycle with binary logistic regression analysis. Cancellation rates were similar between the phenotypes of endometriosis. Conclusions: Poor ovarian reserve, advanced age, presence of adenomyosis, and history of laparotomy are negative prognostic factors associated with intracytoplasmic sperm injection cycle cancellation in endometriosis-related infertility. Antral follicle count is the only independent factor in predicting cycle cancellation. The phenotype of endometriosis does not affect the results.

Download Full-text

The role of diagnostic hysteroscopy before the first in vitro fertilization/intracytoplasmic sperm injection cycle

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-012-2462-8 ◽

2012 ◽

Vol 286 (5) ◽

pp. 1323-1328 ◽

Cited By ~ 10

Author(s):

Hsing-Tse Yu ◽

Chin-Jung Wang ◽

Chyi-Long Lee ◽

Hong-Yuan Huang ◽

Chun-Kai Chen ◽

...

Keyword(s):

In Vitro Fertilization ◽

Intracytoplasmic Sperm Injection ◽

Vitro Fertilization ◽

Diagnostic Hysteroscopy ◽

Injection Cycle

Download Full-text

Negative influence of paternal age on clinical intracytoplasmic sperm injection cycle outcomes in oligozoospermic patients

Fertility and Sterility ◽

10.1016/j.fertnstert.2008.12.043 ◽

2010 ◽

Vol 93 (6) ◽

pp. 1870-1874 ◽

Cited By ~ 40

Author(s):

Renata Cristina Ferreira ◽

Daniela Paes de Almeida Ferreira Braga ◽

Tatiana Carvalho de Souza Bonetti ◽

Fabio Firmbach Pasqualotto ◽

Assumpto Iaconelli ◽

...

Keyword(s):

Intracytoplasmic Sperm Injection ◽

Negative Influence ◽

Paternal Age ◽

Injection Cycle

Download Full-text

Early Serum Progesterone Measurement on 9th Day after Oocyte Retrieval can be used as a Predictor of Fresh Intracytoplasmic Sperm Injection Cycle Success

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2022.7882 ◽

2022 ◽

Vol 10 (B) ◽

pp. 36-41

Author(s):

Shereen Abdulhussien Kzar ◽

Zainab Khafajy ◽

Shatha Sadiq Al-Marayaty

Keyword(s):

Pregnancy Rate ◽

Intracytoplasmic Sperm Injection ◽

Characteristic Curve ◽

Area Under The Curve ◽

Oocyte Retrieval ◽

Fresh Embryo Transfer ◽

Serum Progesterone ◽

Iraqi Women ◽

Predictor Of Success ◽

Injection Cycle

BACKGROUND: In intracytoplasmic sperm injection (ICSI) infertility treatment cycles, measuring serum Progesterone level at day 9 after oocyte retrieval could be used as a predictor of success. METHODS: Sixty-nine women were prospectively included in this study, treated with fresh embryo transfer ICSI cycles. Progesterone analyses were performed on the day of oocyte pick up (day 0) at serum and follicular fluid, then re-assessment at serum on day 9 after oocyte retrieval. The data were compared to evaluate the correlation among hormones measured on day 0 and day 9 with pregnancy rate. RESULTS: Pregnancy rate of Iraqi women was 22% (n = 15), mean serum progesterone on day 9 among pregnant ladies was (mean ± SD, 39.5 ± 13.0) which was significantly higher than that who failed to get pregnant (mean 23.2 ± 11, p = 0.001), then after adjustment of the baseline readings (day 0) estimated mean = 11.1. The differences were still significant, receiver operating characteristic curve area showed that serum Progesterone on day 9 after pick up can differentiate correctly between those who will conceive and those who will not, with a sensitivity = 0.933 and specificity = 0.519, at cut off point = 22.33 and above, (Area under the curve = 0.822, p = 0.001). CONCLUSION: Serum progesterone on day 9 could be one of the predictors of endometrial receptivity and pregnancy, which is actually of great value for both doctors and patients during that stressful period till the date of confirmation, which might negatively affect treatment outcome, as well as the psychosocial and pharmacological impact of medication and limited activity for a failed one.

Download Full-text

Influence of maternal age on intracytoplasmic sperm injection outcome and global deoxyribonucleic acid methylation in women undergoing intracytoplasmic sperm injection cycle

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212145 ◽

2021 ◽

Vol 10 (6) ◽

pp. 2185

Author(s):

Mohammed M. Laqqan ◽

Maged M. Yassin

Keyword(s):

Dna Methylation ◽

Intracytoplasmic Sperm Injection ◽

Methylation Level ◽

Maternal Age ◽

Deoxyribonucleic Acid ◽

Global Dna Methylation ◽

Age Group ◽

Icsi Cycle ◽

Injection Cycle ◽

Positive Significant Correlation

Background: Intracytoplasmic sperm injection needs sufficient oocytes of high quality in order to increase the rate of fertilization and pregnancy. This study was designed to investigate the influence of maternal age on the ICSI outcomes in women undergoing to first ICSI cycle and to evaluate the influence of maternal age on global DNA methylation.Methods: A total of 242 females were included in this study with a mean age of 30.5±7.3 years. The participants were divided into three groups depending on women's age≤25, N=70; 26-35, N=102 and>35, N=70). The genomic DNA was isolated from the blood samples, then the global DNA methylation was evaluated using ELISA.Results: A significant reduction has been found in the level of anti-Müllerian hormone (AMH), total number of the collected oocyte, mature oocytes, fertilized oocytes and number of embryos transferred in the older females compared to the younger group (p<0.001). While a significant increase has been found in global DNA methylation level in the older females compared to the younger group (p<0.001). A positive significant correlation has been found between global DNA methylation level and maternal age (p<0.001). In contrast, a negative significant correlation has been shown between AMH level, mature oocytes and maternal age (p<0.001).Conclusions: Maternal age has a significant influence on the number of mature oocytes, number of embryos transferred and global DNA methylation. The pregnancy chance is more in the age group less than 35 years.

Download Full-text