Antioxidant activity and chemical constituents of essential oil and extracts of Rhizoma Homalomenae

2011 ◽  
Vol 125 (2) ◽  
pp. 456-463 ◽  
Author(s):  
Ling-Bin Zeng ◽  
Zhong-Rong Zhang ◽  
Zhu-Hua Luo ◽  
Ji-Xiao Zhu
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Chemical Constituents

scholarly journals Chemical Constituents and Antioxidant and Biological Activities of the Essential Oil from Leaves of Solanum spirale

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Sukanya Keawsa-ard ◽  
Boonsom Liawruangrath ◽  
Saisunee Liawruangrath ◽  
Aphiwat Teerawutgulrag ◽  
Stephen G. Pyne
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Octadecanoic Acid ◽  
Small Cell Lung ◽  
Hexahydrofarnesyl Acetone ◽  
First Time ◽  
Mcf 7

The essential oil of the leaves Solanum spirale Roxb. was isolated by hydrodistillation and analyzed for the first time using GC and GC-MS. Thirty-nine constituents were identified, constituting 73.36% of the total chromatographical oil components. ( E)-Phytol (48.10%), n-hexadecanoic acid (7.34%), β-selinene (3.67%), α-selinene (2.74%), octadecanoic acid (2.12%) and hexahydrofarnesyl acetone (2.00%) were the major components of this oil. The antioxidant activity of the essential oil was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay. The oil exhibited week antioxidant activity with an IC50 of 41.89 mg/mL. The essential oil showed significant antibacterial activity against both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus with MIC values of 43.0 μg/mL and 21.5 μg/mL, respectively. It also showed significant cytotoxicity against KB (oral cancer), MCF-7 (breast cancer) and NCI-H187 (small cell lung cancer) with the IC50 values of 26.42, 19.69, and 24.02 μg/mL, respectively.

scholarly journals Chemical constituents and antioxidant activity of the essential oil from leaves of Annona vepretorum Mart. (Annonaceae)

2015 ◽  
Vol 11 (43) ◽  
pp. 615 ◽  
Author(s):  
JacksonRoberto Guedes da Silva Almeida ◽  
Camilade Souza Araújo ◽  
AnaPaula de Oliveira ◽  
RafaelyNascimento Lima ◽  
PériclesBarreto Alves ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Chemical Constituents

scholarly journals Ultrasound-Enhanced Subcritical Fluid Extraction of Essential Oil from Nymphaea alba var and Its Antioxidant Activity

2019 ◽  
Vol 102 (5) ◽  
pp. 1448-1454
Author(s):  
Ying Zhao ◽  
Yang-Yang Fan ◽  
Wen-Gang Yu ◽  
Jian Wang ◽  
Wenju Lu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Oil Content ◽  
Chemical Constituents ◽  
Fluid Extraction ◽  
Water Lily ◽  
Nymphaea Alba ◽  
Subcritical Fluid Extraction ◽  
Subcritical Fluid

Abstract Background: The essential oil content of the water lily is extremely low; thus, finding a new method that can extract essential oil from water lilies with a high extraction rate and no residual organic solvents is essential. Objective: The optimal processing conditions for the ultrasound-enhanced subcritical fluid extraction of essential oil from Nymphaea alba var (red water lily) and the antioxidant activity of the essential oil in vitro are investigated to provide theoretical bases for identification and development. Methods: Single-factor experiments and orthogonal designs are performed to determine the effects of extraction conditions on essential oil yields. The chemical composition of essential oil is analyzed using GC–MS. Results: The optimum extraction parameters are established as follows: extraction temperature, 35°C; extraction time, 30 min/time for four times; ratio of material to liquid, 1:3; ultrasound power, 250 W/L; and ultrasonic frequency, 20 kHz. The extraction rate of essential oil is 0.315% under these conditions. Eleven components comprise more than 1% content. The main chemical constituents are 8-hexadecyne (31.04%) and 2,6,10-trimethyl-tetradecane (3.95%). The essential oil from N. alba var has an antioxidant activity in vitro; however, its antioxidant activity is weaker than that of butylated hydroxytoluene. Conclusions: Subcritical fluid is suitable for the extraction of essential oil from N. alba var, and the essential oil has a good antioxidant activity. Highlights: The essential oil content of N. alba var is 0.315%. Forty-seven chemical constituents are identified and isolated from N. alba var and analyzed by GC–MS.

scholarly journals CHEMICAL COMPOSITION, IN VITRO ANTIBACTERIAL, AND ANTIOXIDANT ACTIVITY OF ESSENTIAL OIL FROM LEAVES OF AJUGA PARVIFLORA BENTH

2018 ◽  
Vol 11 (14) ◽  
pp. 57
Author(s):  
Sanjay Kumar ◽  
Mohammad S Javed ◽  
Pawan Kumar ◽  
Rishendra Kumar
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Vitro Assay ◽  
Germacrene D ◽  
Antibacterial And Antioxidant Activity

Objectives: The aim of our study was to evaluate the phytogenic chemical compounds and assess their antibacterial and antioxidant activity of essential oil of Ajuga parviflora Benth. growing in the Himalayan region. Methods: In the present study, the phytochemical constituents of essential oil were isolated by steam distillation and screened by gas chromatography (GC) and GC–mass spectrometry (GC-MS) analysis from A. parviflora is rich in oxygenated monoterpenoids and sesquiterpenoids. The essential oil was further evaluated for their antibacterial by well-diffusion method and antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay at various concentrations. Results: The major chemical constituents were α-cadinol (21.36%), α-muurolol (14.2%), cubebol (12.76%), germacrene D-4-ol (9.6%), germacrene D (4.32%), farnesyl acetate (3.58%), longifolol acetate (2.76%), and β-bourbonene (2.35 %) whereas monoterpenoids were minor constituents. The zone of inhibition (ZOI) shown by essential oil against test bacterial strains at concentration of 500 μg/ml to Gram-negative bacteria Pseudomonas aeruginosa (5.6 mm), Escherichia coli (5 mm), Salmonella typhimurium (8.6 mm), and Proteus vulgaris (10.7 mm) and Gram-positive bacteria Bacillus subtilis (8.3 mm). At the same time, ZOI of standard antibiotic ciprofloxacin against test bacterial strains was P. aeruginosa (9.6 mm), E. coli (14.3mm), S. typhimurium (19.3 mm), P. vulgaris (17.8 mm), and B. subtilis (20.6 mm), respectively. The free radical scavenging property of A. parviflora employed by in vitro assay methods like scavenging activity of DPPH was 81% at 500 μg/ml concentrations, respectively. Conclusion: Our study showed that α-cadinol, α-muurolol, and cubebol as the major components in this oil which was absent in previous findings of A. parviflora and essential oil had potent antibacterial and antioxidant activity, respectively.

Chemical Constituents, Antioxidant Activity and Cytotoxic Effects of Essential Oil from Strobilanthes crispus and Lawsonia inermis

2006 ◽  
Vol 6 (6) ◽  
pp. 1005-1010 ◽  
Author(s):  
Asmah Rahmat . ◽  
Susi Edrini . ◽  
Patimah Ismail . ◽  
Taufiq Yap Yun Hin . ◽  
Mohd Fadzelly Abu Ba .
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Lawsonia Inermis ◽  
Cytotoxic Effects ◽  
Strobilanthes Crispus

scholarly journals Chemical Composition and Biological Activity of the Essential Oil of Amomum biflorum

2013 ◽  
Vol 8 (2) ◽  
pp. 1934578X1300800
Author(s):  
Chakkrapat Singtothong ◽  
Michel J. Gagnon ◽  
Jean Legault
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Antioxidant Activity ◽  
Chemical Composition ◽  
Essential Oil ◽  
Chemical Constituents ◽  
Average Yield ◽  
Kovats Index ◽  
Whole Plant ◽  
Major Chemical

The aim of this study was to investigate the chemical composition and bioactivity of Amomum biflorum Jack harvested in the region of Petchaboon, Thailand. The essential oil of the fresh whole plant obtained by hydrodistillation was analyzed by gas chromatography (GC) (Kovats index) and gas chromatography coupled with mass spectrometry (GC/MS). The average yield of essential oil of A. biflorum was 0.21 ± 0.05 % (w/w). The major chemical constituents were camphor (17.6 %), α-bisabolol (16.0 %), camphene (8.2 %) and α-humulene (5.1 %). The essential oil was active against Staphylococcus aureus (MIC: 30 μ/mL) and had an antioxidant activity with an ORAC index of 23 ± 5 μmol Trolox/mg.

scholarly journals Antioxidant Activities of a New Chemotype of Piper cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies

Plants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1534
Author(s):  
Fahad Alminderej ◽  
Sana Bakari ◽  
Tariq I. Almundarij ◽  
Mejdi Snoussi ◽  
Kaïss Aouadi ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Molecular Docking ◽  
Essential Oil ◽  
Antioxidant Activities ◽  
Chemical Constituents ◽  
Radical Scavenging ◽  
Butylated Hydroxytoluene ◽  
Scavenging Activity ◽  
Important Species ◽  
Antioxidant Power

Piper cubeba L. fruit is an important species used in folk medicine for different types of pains such as rheumatism, chills, flu, colds, muscular aches, and fever. This study examines the chemical constituents, antioxidant activity, and potential inhibitory effect against human peroxiredoxin 5, a key enzyme of P. cubeba essential oil from fruits. Using gas chromatography coupled with mass spectrometry (GC–MS), the principal components were methyleugenol (41.31%) and eugenol (33.95%), followed by (E)-caryophyllene (5.65%), p-cymene-8-ol (3.50%), 1,8-cineole (2.94%), and α-terpinolene (1.41%). Results showed similar scavenging activity via 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity (IC50 = 110.00 ± 0.08 μg/mL), as well as very potent antioxidant activity against both ferric reducing/antioxidant power (FRAP) (106.00 ± 0.11 μg/mL) and β-carotene bleaching (IC50 = 315.00 ± 2.08 μg/mL) assays when compared to positive butylated hydroxytoluene and ascorbic acid. The molecular docking approach has also been performed to screen the antioxidant activities of the major and potent compounds against human protein target peroxiredoxin 5. Results showed good binding profiles and attributed the strongest inhibitory activity to β-caryophyllene oxide (–5.8 kcal/mol), followed respectively by isocembrol and α-selinene (–5.4 kcal/mol), and viridiflorol (–5.1 kcal/mol). Furthermore, ADME (absorption, distribution, metabolism and excretion)-related physicochemical and pharmacokinetic properties have been assessed and support our in vitro findings. This work demonstrates the powerful antioxidant potency of cubeba pepper and paves the way for the discovery and development of antioxidant agent with high potency.

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