Amaranth seed protein hydrolysates have in vivo and in vitro antihypertensive activity

2011 ◽  
Vol 126 (3) ◽  
pp. 878-884 ◽  
Author(s):  
Mariana Fritz ◽  
Bruno Vecchi ◽  
Gustavo Rinaldi ◽  
María Cristina Añón
Keyword(s):  
Seed Protein ◽  
Protein Hydrolysates ◽  
Antihypertensive Activity ◽  
Amaranth Seed

scholarly journals Multifunctional hydrolysates from kenaf (Hibiscus cannabinus L.) seed protein with high antihypertensive activity in vitro and in vivo

2020 ◽  
Author(s):  
Nurul Dhania Zaharuddin ◽  
Mohamad Ariff Hanafi ◽  
Shyan Yea Chay ◽  
Farah Salina Hussin ◽  
Shehu Muhammad Auwal ◽  
...  
Keyword(s):  
Seed Protein ◽  
Hibiscus Cannabinus ◽  
Antihypertensive Activity

In vitro and in vivo antihypertensive activity of palm kernel cake protein hydrolysates: Sequencing and characterization of potent bioactive peptides

2015 ◽  
Vol 76 ◽  
pp. 112-120 ◽  
Author(s):  
Mohammad Zarei ◽  
Bita Forghani ◽  
Afshin Ebrahimpour ◽  
Azizah Abdul-Hamid ◽  
Farooq Anwar ◽  
...  
Keyword(s):  
Bioactive Peptides ◽  
Palm Kernel ◽  
Protein Hydrolysates ◽  
Antihypertensive Activity ◽  
Palm Kernel Cake

Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats

2020 ◽  
Vol 20 (8) ◽  
pp. 1253-1261
Author(s):  
Mourad Akdad ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Cardiovascular System ◽  
Arterial Blood Pressure ◽  
Antihypertensive Activity ◽  
Computer Assisted ◽  
Hypertensive Rats ◽  
Vasorelaxant Effect ◽  
Arterial Blood

Aims: The present study was performed in order to analyze the antihypertensive activity of Micromeria graeca (L.) Benth. ex Rchb. Background: Micromeria graeca (L.) Benth. ex Rchb is an aromatic and medicinal plant belonging to the Lamiaceae family. This herb is used to treat various pathologies such as cardiovascular disorders. Meanwhile, its pharmacological effects on the cardiovascular system have not been studied. Objective: The present study aimed to evaluate the effect of aqueous extract of aerial parts of Micromeria graeca (AEMG) on the cardiovascular system in normotensive and hypertensive rats. Methods: In this study, the cardiovascular effect of AEMG was evaluated using in vivo and in vitro investigations. In order to assess the acute effect of AEMG on the cardiovascular system, anesthetized L-NAME-hypertensive and normotensive rats received AEMG (100 mg/kg) orally and arterial blood pressure parameters were monitored during six hours. In the sub-chronic study, rats were orally treated for one week, followed by blood pressure assessment during one week of treatment. Blood pressure was measured using a tail-cuff and a computer-assisted monitoring device. In the second experiment, isolated rat aortic ring pre-contracted with Epinephrine (EP) or KCl was used to assess the vasorelaxant effect of AEMG. Results: Oral administration of AEMG (100 mg/kg) provoked a decrease of arterial blood pressure parameters in hypertensive rats. In addition, AEMG induced a vasorelaxant effect in thoracic aortic rings pre-contracted with EP (10 μM) or KCl (80 mM). This effect was attenuated in the presence of propranolol and methylene blue. While in the presence of glibenclamide, L-NAME, nifedipine or Indomethacin, the vasorelaxant effect was not affected. Conclusion: This study showed that Micromeria graeca possesses a potent antihypertensive effect and relaxes the vascular smooth muscle through β-adrenergic and cGMP pathways.

Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An in vitro and in vivo Approach

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohammed Ajebli ◽  
Mohamed Eddouks
Keyword(s):  
Blood Pressure ◽  
Acute Experiment ◽  
Antihypertensive Activity ◽  
Mentha Pulegium ◽  
In Vitro Experiment ◽  
Arterial Blood ◽  
Dose Dependent ◽  
Ca2 Channels

Aims and objective: The aim of the study was to investigate the effect of aqueous aerial part extract of Mentha pulegium L. (Pennyrile) (MPAE) on arterial pressure parameters in rats. Background: Mentha pulegium is a medicinal plant used to treat hypertension in Morocco. Material and methods: In the current study, MPAE was prepared and its antihypertensive activity was pharmacologically investigated. L-NAME-hypertensive and normotensive rats have received orally MPAE (180 and 300 mg/kg) during six hours for the acute experiment and during seven days for the sub-chronic treatment. Thereafter, systolic, diastolic, mean arterial blood pressure and heart rate were evaluated. While, in the in vitro experiment, isolated denuded and intact thoracic aortic rings were suspended in a tissue bath system and the tension changes were recorded. Results: A fall in blood pressure was observed in L-NAME-induced hypertensive treated with MPAE. The extract also produced a dose-dependent relaxation of aorta pre-contracted with NE and KCl. The study showed that the vasorelaxant ability of MPAE seems to be exerted through the blockage of extracellular Ca2+ entry. Conclusion: The results demonstrate that the extract of pennyrile exhibits antihypertensive activity. In addition, the effect may be, at least in part, due to dilation of blood vessels via blockage of Ca2+ channels.

In vitro and in vivo antioxidant capacity of chia protein hydrolysates and peptides

2019 ◽  
Vol 91 ◽  
pp. 19-25 ◽  
Author(s):  
Michele Silveira Coelho ◽  
Sabrine de Araujo Aquino ◽  
Juliana Machado Latorres ◽  
Myriam de las Mercedes Salas-Mellado
Keyword(s):  
Antioxidant Capacity ◽  
Protein Hydrolysates

scholarly journals In vitro and In vivo Interactions of Diltiazem with Ibuprofen and Naproxen in Aqueous Medium and Rabbits

1970 ◽  
Vol 5 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Md. Shah Amran ◽  
AHM Rashidul Bari ◽  
Md. Amjad Hossain
Keyword(s):  
Aqueous Medium ◽  
Medical Science ◽  
Antihypertensive Activity ◽  
Concurrent Administration ◽  
Key Words Drug Interaction ◽  
The Stability ◽  
Multiple Drugs ◽  
Mercury Manometer

A common practice in the medical science is the prescription of multiple drugs at a time, which may sometimes be neither safe nor effective and may be deleterious. The present study was aimed to evaluate such a combination of diltiazem with ibuprofen and naproxen. The invitro interaction of diltiazem with ibuprofen and naproxen has been studied at room temperature and at different pH in the aqueous medium by spectroscopic and conductometric methods, and the invivo study was done in the rabbit by measuring blood pressure using a mercury manometer. It has been found that diltiazem formed stable 1 : 1 complexes with ibuprofen and naproxen along with some intermediates. The Ardon’s spectrophotometric method was employed to confirm the formation of 1 : 1 complex and for the calculation of the stability constants. The invivo study was carried out to evaluate the influence of ibuprofen and naproxen on the antihypertensive activity of diltiazem in the rabbit. Concurrent administration of ibuprofen and naproxen with diltizem did not make any significant change in the antihypertensive activity of diltiazem. It is thus inferred that co-administration of diltiazem with ibuprofen and naproxen may be considered as safe and effective. Key words: Drug interaction, complexation, co-administration, diltiazem, naproxen, ibuprofen, stability constant Dhaka Univ. J. Pharm. Sci. Vol.5(1-2) 2006 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

scholarly journals Advance on anti-diabetic effects of protein hydrolysates and peptides derived from cereals and pseudocereals

2020 ◽  
Vol 189 ◽  
pp. 02030
Author(s):  
Weijing Wu ◽  
Wen Xie ◽  
Qianglai Tan ◽  
Lanlan Wu ◽  
Shanshan Zhu ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Bioactive Peptides ◽  
Cell Model ◽  
Digestive Enzyme ◽  
Protein Hydrolysates ◽  
Staple Food ◽  
Elevated Blood ◽  
Global Public Health

Diabetes is a complex and heterogeneous disorder disease with elevated blood glucose, which is one of the most serious global public health problems. Cereals and pseudocereals, as staple food, are major sources of dietary protein. Cereal and pseudocereal proteins are potential sources of food-derived bioactive peptides and proposed to prevent and ameliorate diabetes. According to recent researches, this review summaries the isolation, purification and analysis of anti-diabetic protein hydrolysates and peptides from cereals and pseudocereals. In addition, their anti-diabetic activities and mechanisms were reviewed by in vitro inhibition of carbohydrate digestive enzyme and dipeptidyl peptidase-IV, in vivo hypoglycaemic effects, and glucose homeostasis in cell model.

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