Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation

2021 ◽  
Author(s):  
Sina Bader ◽  
Julia Wilmers ◽  
Martin Pelzer ◽  
Verena Jendrossek ◽  
Justine Rudner
Keyword(s):  
Ionizing Radiation ◽  
Nrf2 Pathway ◽  
Anti Oxidant

scholarly journals Effects of Gastrodin against Lead-Induced Brain Injury in Mice Associated with the Wnt/Nrf2 Pathway

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1805
Author(s):  
Chan-Min Liu ◽  
Zhi-Kai Tian ◽  
Yu-Jia Zhang ◽  
Qing-Lei Ming ◽  
Jie-Qiong Ma ◽  
...  
Keyword(s):  
Phenolic Glycoside ◽  
Related Factor ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Nrf2 Pathway ◽  
Wnt Inhibitor ◽  
Research Findings ◽  
Anti Oxidant ◽  
Underlying Mechanisms ◽  
Induced Apoptosis

Gastrodin (GAS), the main phenolic glycoside extracted from Gastrodia elata Blume, exhibited potential neuroprotective properties. Here we examined the protective effects of GAS against lead(Pb)-induced nerve injury in mice, and explores its underlying mechanisms. Our research findings revealed that GAS improved behavioral deficits in Pb-exposed mice. GAS reduced the accumulation of p-tau and amyloid-beta (Aβ). GAS inhibited Pb-induced inflammation in the brain, as indicated by the decreased levels of pro-inflammatory cytokines, including tumor necrosis factor-a (TNF-α), cyclooxygenase-2 (COX-2). GAS increased the expression levels of NR2A and neurotrophin brain-derived neurotrophic factor (BDNF). GAS inhibited Pb-induced apoptosis of neurons in hippocampus tissue, as indicated by the decreased levels of pro-apoptotic proteins Bax and cleaved caspase-3. Furthermore, the neuroprotective effects of GAS were associated with inhibiting oxidative stress by modulating nuclear factor-erythroid 2-related factor 2 (Nrf2)-mediated antioxidant signaling. GAS supplement activated the Wnt/β-catenin signaling pathway and reduced the expression of Wnt inhibitor Dickkopf-1 (Dkk-1). Collectively, this study clarified that GAS exhibited neuroprotective property by anti-oxidant, anti-inflammatory and anti-apoptosis effects and its ability to regulate the Wnt/Nrf2 pathway.

scholarly journals Extreme anti-oxidant protection against ionizing radiation in bdelloid rotifers

2012 ◽  
Vol 109 (7) ◽  
pp. 2354-2357 ◽  
Author(s):  
A. Krisko ◽  
M. Leroy ◽  
M. Radman ◽  
M. Meselson
Keyword(s):  
Ionizing Radiation ◽  
Bdelloid Rotifers ◽  
Anti Oxidant

scholarly journals ERK-Nrf2 pathway regulates the anti-oxidant response after in vitro diesel exhaust particles treatment

2015 ◽  
Vol 238 (2) ◽  
pp. S283
Author(s):  
F. Farina ◽  
C. Milani ◽  
L. Botto ◽  
E. Lonati ◽  
A. Bulbarelli ◽  
...  
Keyword(s):  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Nrf2 Pathway ◽  
Anti Oxidant ◽  
Exhaust Particles

Theaflavin ameliorates ionizing radiation-induced hematopoietic injury via the NRF2 pathway

2017 ◽  
Vol 113 ◽  
pp. 59-70 ◽  
Author(s):  
Xiaodan Han ◽  
Junling Zhang ◽  
Xiaolei Xue ◽  
Yu Zhao ◽  
Lu Lu ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Nrf2 Pathway ◽  
Radiation Induced

scholarly journals Antioxidant and Anti-inflammatory Activities Mediate the Radioprotective Effect of Trianthema Portulacastrum L. Extracts

2021 ◽  
Author(s):  
Uttam Das ◽  
Tanmay Saha ◽  
Reshma Kumari Sharma ◽  
Dharmendra Kumar Maurya ◽  
Partho Sarothi Ray ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cell Viability ◽  
The Body ◽  
No Production ◽  
Low Concentration ◽  
Trianthema Portulacastrum ◽  
Radiation Induced ◽  
Stem Extract ◽  
Anti Oxidant ◽  
Anti Inflammatory

Abstract Ionizing radiation (IR) generates reactive oxygen species (ROS) which leads to oxidative stress and often leads to inflammatory responses in organisms. Trianthema portulacastrum L., a plant commonly growing in India, is rich in antioxidant phytochemicals which is responsible for scavenging free radicals, and may provide radio-protective and anti-inflammatory effects in response to ionizing radiation. The effect of T. portulacastrum extracts was studied in hepatic cells, which are susceptible to radiation-induced damage, and in macrophages which are the primary inflammatory cells of the body. T. portulacastrum stem extracts showed efficient free radical scavenging activity in hepatocytes and reduction of radiation-induced lipid peroxidation in cell and mitochondrial membranes. Treatment of irradiated cells with T. portulacastrum stem extracts enhanced cell viability, although at higher concentrations there was reduction in cell viability. Treatment with low concentration of T. portulacastrum stem extract also reduced cellular ROS generation and increased cellular concentration of the anti-oxidant glutathione. T. portulacastrum extracts also showed a marked anti-inflammatory effect in macrophages activated by the inflammatory agonist bacterial lipopolysaccharide (LPS) by reducing inflammatory gene expression and nitric oxide (NO) production, and increasing glutathione content. LPS treatment lowered expression of Nrf2, a transcription factor involved in regulation of multiple anti-oxidant genes, while treatment with low concentration of T. portulacastrum stem extract significantly restored it. Together, these observations demonstrated a potential radioprotective role of T. portulacastrum extract mediated by both its antioxidant activity on hepatic epithelial cells and its anti-inflammatory activity on immune cells

Radiation-induced surface decomposition

1983 ◽  
Vol 41 ◽  
pp. 368-369
Author(s):  
M. L. Knotek
Keyword(s):  
Ionizing Radiation ◽  
Atomic Structure ◽  
Chemical Bonding ◽  
Neutral Species ◽  
Radiation Induced ◽  
Physical And Chemical ◽  
Surface Decomposition ◽  
The Relationship ◽  
Electron And Photon ◽  
Surface Bond

Modern surface analysis is based largely upon the use of ionizing radiation to probe the electronic and atomic structure of the surfaces physical and chemical makeup. In many of these studies the ionizing radiation used as the primary probe is found to induce changes in the structure and makeup of the surface, especially when electrons are employed. A number of techniques employ the phenomenon of radiation induced desorption as a means of probing the nature of the surface bond. These include Electron- and Photon-Stimulated Desorption (ESD and PSD) which measure desorbed ionic and neutral species as they leave the surface after the surface has been excited by some incident ionizing particle. There has recently been a great deal of activity in determining the relationship between the nature of chemical bonding and its susceptibility to radiation damage.

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