Redox modulation by plant polyphenols targeting vitagenes for chemoprevention and therapy: Relevance to novel anti-cancer interventions and mini-brain organoid technology

Mechanisms of anti-cancer effects of polyphenols, found in fruits, vegetables, spices and representing parts of daily nutrition, have been considered. These compounds may be the basis for development of cancer preventive preparations. They can block carcinogenesis initiation by inactivation of exogenous or endogenous genotoxic molecules including reactive oxygen species. Another mechanism consists in inhibition of activity and synthesis of carcinogen-metabolizing enzymes. Plant polyphenols also induce expression of antioxidant and detoxification enzymes genes.

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Anti-cancer effects of polyphenol-rich sugarcane extract

PLoS ONE ◽

10.1371/journal.pone.0247492 ◽

2021 ◽

Vol 16 (3) ◽

pp. e0247492

Author(s):

Monica D. Prakash ◽

Lily Stojanovska ◽

Jack Feehan ◽

Kulmira Nurgali ◽

Elizabeth L. Donald ◽

...

Keyword(s):

Cancer Cells ◽

Cell Lines ◽

Human Colon ◽

Biological Properties ◽

Human Lung Cancer ◽

Epithelial Cell Line ◽

Human Leukemia ◽

Plant Polyphenols ◽

Anti Cancer ◽

Colon Epithelial Cell

Plant polyphenols have an array of health benefits primarily thought to be related to their high content of anti-oxidants. These are commonly undervalued and knowledge of their biological properties have grown exponentially in the last decade. Polyphenol-rich sugarcane extract (PRSE), a natural extract from sugar cane, is marketed as high in anti-oxidants and polyphenols, but its anti-cancer activity has not been reported previously. We show that, PRSE exerts anti-cancer properties on a range of cancer cells including human (LIM2045) and mouse (MC38, CT26) colon cancer cells lines; human lung cancer (A549), human ovarian cancer (SKOV-3), pro-monocytic human leukemia (U937) and to mouse melanoma (B16) cell lines; whereas no effects were noted on human breast (ZR-75-1) and human colon (HT29) cancer cell lines, as well as to human normal colon epithelial cell line (T4056). Anti-proliferative effects were shown to be mediated via alteration in cytokines, VEGF-1 and NF-κB expression.

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Evaluation of Plant Polyphenols as Anti‐inflammatory and Anti‐cancer Agents

The FASEB Journal ◽

10.1096/fasebj.21.6.a735-b ◽

2007 ◽

Vol 21 (6) ◽

Author(s):

Seung‐Yeon Oh ◽

Eun‐Ju Lee ◽

Mi‐Kyung Sung

Keyword(s):

Plant Polyphenols ◽

Anti Cancer ◽

Anti Inflammatory

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Combinations of Plant Polyphenols & Anti-Cancer Molecules: A Novel Treatment Strategy for Cancer Chemotherapy

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520611313020015 ◽

2013 ◽

Vol 13 (2) ◽

pp. 281-295 ◽

Cited By ~ 35

Author(s):

Aarti Mohan ◽

Shridhar Narayanan ◽

Swaminathan Sethuraman ◽

Uma Maheswari Krishnan

Keyword(s):

Cancer Chemotherapy ◽

Treatment Strategy ◽

Plant Polyphenols ◽

Novel Treatment ◽

Anti Cancer

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Mechanisms of anti-cancer effects of plant polyphenols II. Suppression on tumor growth

Biomeditsinskaya Khimiya ◽

10.18097/pbmc20125803257 ◽

2012 ◽

Vol 58 (3) ◽

pp. 257-271 ◽

Cited By ~ 2

Author(s):

V.N. Zinov'eva ◽

A.A. Spasov

Keyword(s):

Gene Expression ◽

Cell Cycle ◽

Signal Transduction ◽

Tumor Cells ◽

Tumor Metastasis ◽

Plant Polyphenols ◽

Cycle Arrest ◽

Anti Cancer ◽

Cell Signal Transduction ◽

Inhibit Tumor Metastasis

Mechanisms of suppression of carcinogenesis promotion/progression by plant polyphenols have been considered. They can decrease cyclins and cycline dependent kinases and activate inhibitor proteins in tumor cells that results in cell cycle arrest. Plant polyphenols can induce apoptosis by modulating anti/proapoptotic proteins and also can inhibit tumor metastasis and angiogenesis. Polyphenols act through the regulation of cell signal transduction and gene expression.

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