Association of FoxP3 promoter polymorphisms with the risk of Graves' disease in ethnic Kashmiri population

Gene ◽  
2018 ◽  
Vol 672 ◽  
pp. 88-92 ◽  
Author(s):  
Faheem Shehjar ◽  
Dil Afroze ◽  
Raiz A. Misgar ◽  
Sajad A. Malik ◽  
Bashir A. Laway
Keyword(s):  
Graves Disease ◽  
Promoter Polymorphisms ◽  
Kashmiri Population

A significant association of the CTLA4 gene variants with the risk of autoimmune Graves’ disease in ethnic Kashmiri population

2020 ◽  
Vol 347 ◽  
pp. 103995 ◽  
Author(s):  
Faheem Shehjar ◽  
Dil-Afroze ◽  
Riaz A Misgar ◽  
Sajad A Malik ◽  
Bashir A Laway
Keyword(s):  
Graves Disease ◽  
Gene Variants ◽  
Kashmiri Population ◽  
Ctla4 Gene

Matrix metalloproteinase (MMP) -2, -7 and -9 promoter polymorphisms in colorectal cancer in ethnic Kashmiri population — A case–control study and a mini review

Gene ◽  
2016 ◽  
Vol 589 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Mujeeb Zafar Banday ◽  
Aga Syed Sameer ◽  
Ashaq Hussain Mir ◽  
Taseem A. Mokhdomi ◽  
Nissar A. Chowdri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteinase ◽  
Case Control Study ◽  
Case Control ◽  
Promoter Polymorphisms ◽  
Kashmiri Population ◽  
Control Study

Cytokine promoter polymorphisms in Taiwanese patients with Graves' disease

2007 ◽  
Vol 40 (3-4) ◽  
pp. 213-217 ◽  
Author(s):  
Ming-Yuh Shiau ◽  
Chien-Ning Huang ◽  
Tzi-Peng Yang ◽  
Yi-Ching Hwang ◽  
Kan-Jen Tsai ◽  
...  
Keyword(s):  
Graves Disease ◽  
Promoter Polymorphisms

scholarly journals Correlation between Interleukin-4 Gene Promoter Polymorphisms with Thyrotropin Receptor Antibody and Transforming Growth Factor-β

2020 ◽  
Vol 8 (A) ◽  
pp. 793-796
Author(s):  
Raveinal Raveinal ◽  
Eryati Darwin ◽  
Eva Decroli ◽  
Jamsari Jamsari
Keyword(s):  
Transforming Growth Factor ◽  
Gene Promoter ◽  
Transforming Growth Factor Β ◽  
Interleukin 4 ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Wild Type ◽  
Promoter Polymorphisms ◽  
Thyrotropin Receptor Antibody ◽  
The Mean

AIM: The aim of this study was to determine the correlation between interleukin-4 (IL-4) gene promoter polymorphisms with thyrotropin receptor antibody (TRAb) and transforming growth factor-β (TGF-β). METHODS: This study was conducted from August 2015 until December 2015 in the internal medicine department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. Graves’ disease was confirmed by measuring free thyroxine, thyroid-stimulating hormone, and TRAb. We examined that IL-4 promotor gene polymorphism was examined with a polymerase chain reaction. Graves’ disease serum patients will be used to check levels of TGFβ and TRAb antibodies using the enzyme-linked immunoassay method. RESULTS: There are 15 patients in this study. The average of age in patients group is 40.87 (11.23) years. The number of female patients in this study is more than male patients, with the percentage of women are 73.3%, and men are 26.7%. The sequencing examination on IL-4 gene promoter resulted in 2 single nucleotide polymorphism motifs, which are rs2243250 and rs2070847. The mean TRAb level in wild type and mutant group is 6.77 (5.73) IU/L and 4.66 (3.91) IU/L, respectively. The mean TGF-β levels in wild type and mutant group are 1168.89 (438.91) pg/mL and 1114.79 (296.02) pg/mL, respectively. Statistical tests showed no association between IL-4 gene promoter polymorphisms with TRAb and TGF-β levels (p > 0.05). CONCLUSION: There is no correlation between IL-4 gene promoter polymorphisms with TRAb and TGF-β.

Association of polymorphic variants of IL-1β and IL-1RN genes in the development of Graves’ disease in Kashmiri population (North India)

2018 ◽  
Vol 79 (4) ◽  
pp. 228-232 ◽  
Author(s):  
Faheem Shehjar ◽  
Dil Afroze ◽  
Raiz A. Misgar ◽  
Sajad A. Malik ◽  
Bashir A. Laway
Keyword(s):  
North India ◽  
Graves Disease ◽  
Kashmiri Population ◽  
Polymorphic Variants

scholarly journals PTPN22 1858 C/T exon polymorphism is not associated with Graves' disease in Kashmiri population

2018 ◽  
Vol 22 (4) ◽  
pp. 457 ◽  
Author(s):  
BashirA Laway ◽  
Faheem Shehjar ◽  
Dil-Afroze ◽  
RiazA Misgar ◽  
SajadA Malik
Keyword(s):  
Graves Disease ◽  
Kashmiri Population

scholarly journals THE ROLE OF INTERLEUKIN-4 GENE PROMOTER POLYMORPHISMS IN GRAVES’ DISEASE

2020 ◽  
pp. 73-75
Author(s):  
RAVEINAL RAVEINAL ◽  
ERYATI DARWIN ◽  
EVA DECROLI ◽  
JAMSARI JAMSARI
Keyword(s):  
Statistical Tests ◽  
Gene Promoter ◽  
Normal Subjects ◽  
Promoter Polymorphism ◽  
Interleukin 4 ◽  
Control Group ◽  
Graves Disease ◽  
Promoter Polymorphisms ◽  
And Control

Objective: This study was conducted to prove the role of interleukin-4 gene promoter polymorphisms in Graves’ disease patients in M Djamil General Hospital Padang, Indonesia. Methods: This study was conducted from August 2015 until December 2015 in the Internal Medicine Department in Dr. M. Djamil Hospital, Padang, West Sumatera, Indonesia. This study involved 15 patients with Graves’ disease and 15 normal subjects. We examined that IL-4 promoter gene polymorphism was examined with PCR. Results: Sequencing examination on IL-4 gene promoter resulted in 2 Single Nucleotide Polymorphism (SNP) motifs, which is rs2243250 and rs2070847. IL-4 SNP gene promoter polymorphisms rs2243250 and rs2070847 were found in both patient and control groups. TT is homozygous SNP polymorphisms. CT is heterozygous SNP polymorphisms. CC is wild type or no mutation SNP polymorphisms. Based on statistical tests, no difference in rs2243250 and rs2070847 SNP polymorphisms was found between patient and control group (p > 0.05). Conclusion: This study observed no difference in interleukin-4 gene promoter polymorphism between Graves’ disease patients and control group.

scholarly journals CORRELATION BETWEEN POLYMORPHISMS OF FOXP3 T-REGULATORY PROMOTOR GENE WITH TGF-β IN PATIENTS WITH GRAVES’ DISEASE

2020 ◽  
pp. 133-135
Author(s):  
DWITYA ELVIRA
Keyword(s):  
Transforming Growth Factor ◽  
Female Gender ◽  
Polymerase Chain Reaction Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Graves Disease ◽  
Nucleotide Polymorphisms ◽  
Promoter Polymorphisms ◽  
Cross Sectional ◽  
Promoter Gene

Objective: The aim of this study is to prove that there are Forkhead Box P3 (FOXP3) T-regulator promoter polymorphisms in Graves’ disease and to analyze the association between FOXP3 T-regulator promoter polymorphisms with transforming growth factor (TGF)-β levels. Methods: This study was an observational study with cross-sectional comparative study design. Consecutive sampling was conducted in patients with Graves’ disease who came to the outpatient clinic and treated in Dr. M. Djamil Hospital, Padang. Blood sampling was performed on 30 Graves’ subjects and 30 control subjects based on inclusion and exclusion criteria. DNA isolation, primary construction, and polymorphism identification by polymerase chain reaction method and blood sample examination by enzyme-linked immunosorbent assay techniques method for TGF-β examination were performed in this study. Results: The results of this study obtained the most age of patients with Graves’ disease is 30–40 years with the female gender. Graves’ patient group was found to have 86.7% of single nucleotide polymorphisms (SNP) rs3761548 polymorphism, and 61.3% had SNP rs2232365 polymorphism followed by 26.7% polymorphism of SNP rs3761547 and rs3761549, and no SNP rs2232364 polymorphism was found. In Graves’ group, the mean value of TGF-β was 1030.01±277.64 ng/ml, significantly higher than the control group. Statistical analysis showed a significant relationship between polymorphism of the FOXP3 promoter gene and TGF-β level with p<0.05. Conclusion: This study proves that there are polymorphisms of the FOXP3 promoter gene in Graves’ patients, especially SNP rs3761548 and rs2232365. The polymorphism of the FOXP3 promoter gene has a significant association with TGF-β levels.

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