Serum levels of vitamin D and immune system function in patients with COVID-19 admitted to intensive care unit

Research has implicated immune system inflammation as an underlying etiology of multi-symptom illnesses, and vitamin D has been shown to have a significant role in immune system function. In this retrospective review performed on the medical charts of service members who presented with signs and symptoms of multi-symptom illnesses, we focused on serum 25(OH)D3 levels and looked for associations of vitamin D status (deficient, insufficient, and normal) with age (20–31 years versus 31–56 years) and deployment status (war zones versus other). Two groups (U.S. Marines and Navy Sailors) were sampled and both showed high incidences of below normal vitamin D levels. However, with the Marines, age-related differences in serum levels (p = 0.009) were found only among those who deployed to Iraq/Afghanistan in comparison to those in non-combat locations. The comparison within the Navy sample showed that mobilized sailors had lower 25(OH)D3 levels than the group that did not deploy (p = 0.04). In addition, 100% of the sailors who deployed had below normal levels versus only 33% in the cadre group. The data suggest that personnel returning from a war zone with signs of early multi-symptom illness should be checked for low vitamin D status.

Download Full-text

Dysregulated vitamin D metabolism and impaired immune system function

Journal of Immunological Techniques in Infectious Diseases ◽

10.4172/2329-9541-c1-008 ◽

2018 ◽

Vol 07 ◽

Author(s):

Meg Mangin

Keyword(s):

Vitamin D ◽

Immune System ◽

System Function ◽

Vitamin D Metabolism ◽

Immune System Function

Download Full-text

Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study

Medicine in Drug Discovery ◽

10.1016/j.medidd.2020.100064 ◽

2020 ◽

Vol 8 ◽

pp. 100064 ◽

Cited By ~ 10

Author(s):

Cristian Arvinte ◽

Maharaj Singh ◽

Paul E. Marik

Keyword(s):

Intensive Care Unit ◽

Vitamin D ◽

Intensive Care ◽

Pilot Study ◽

Vitamin C ◽

Critically Ill ◽

North American ◽

Community Hospital ◽

Serum Levels ◽

Hospital Intensive Care Unit

Download Full-text

EFFECT OF PETTING A DOG ON IMMUNE SYSTEM FUNCTION

Psychological Reports ◽

10.2466/pr0.95.7.1087-1091 ◽

2004 ◽

Vol 95 (7) ◽

pp. 1087 ◽

Cited By ~ 14

Author(s):

CARL J. CHARNETSKI

Keyword(s):

Immune System ◽

System Function ◽

Immune System Function

Download Full-text

Vitamin D Measurement in the Intensive Care Unit: Methodology, Clinical Relevance and Interpretation of a Random Value

Inflammation & Allergy - Drug Targets ◽

10.2174/18715281113129990050 ◽

2013 ◽

Vol 12 (4) ◽

pp. 230-238 ◽

Cited By ~ 10

Author(s):

Anand Krishnan ◽

Bala Venkatesh

Keyword(s):

Intensive Care Unit ◽

Vitamin D ◽

Intensive Care ◽

Clinical Relevance

Download Full-text

Effects of Long-Term Supplementation of Bovine Colostrum on the Immune System in Young Female Basketball Players. Randomized Trial

Nutrients ◽

10.3390/nu13010118 ◽

2020 ◽

Vol 13 (1) ◽

pp. 118

Author(s):

Anna Skarpańska-Stejnborn ◽

Mirosława Cieślicka ◽

Hanna Dziewiecka ◽

Sławomir Kujawski ◽

Anita Marcinkiewicz ◽

...

Keyword(s):

Immune System ◽

Physical Exercise ◽

Exercise Program ◽

Bovine Colostrum ◽

Control Group ◽

System Function ◽

Basketball Players ◽

Immune System Function ◽

Experimental Group

An intensive physical exercise program could lead to a decrease in immune system function. Effects of long-term supplementation of bovine colostrum on the response of immune function on physical exercise test in athletes were examined. Twenty-seven elite female basketball players (age 16–19) were randomly assigned to either an experimental group or a control group. Eventually, n = 11 athletes completed intervention in the experimental group (3.2 g bovine colostrum orally twice a day for 24 weeks), while n = 9 athletes in the control group were given a placebo. Before the supplementation, after 3 and 6 months, subjects performed the physical exercise stress test. Before, just after, and 3 h after physical exercise testing, blood was drawn and immune system indicators were examined. Plasma interleukin (IL)-1alpha, IL-2, IL-10, IL-13, tumor necrosis factor (TNF) alpha, creatine kinase (CK MM), immunoglobulin G (IgG), insulin-like growth factor 1 (IGF1), and WBC, lymphocyte (LYM), monocyte (MON), and granulocyte (GRA) were measured. A statistically significant change in IL-10 in response to the exercise program during the supplementation period in both groups was observed (p = 0.01). However, the results of the rest of the comparisons were statistically insignificant (p > 0.05). Contrary to our initial hypothesis, there were no significant effects of bovine supplementation on the dynamics of immune system function indicators.

Download Full-text

Physical exercise and immune system function in cancer survivors

Cancer ◽

10.1002/cncr.10244 ◽

2002 ◽

Vol 94 (2) ◽

pp. 539-551 ◽

Cited By ~ 91

Author(s):

Adrian S. Fairey ◽

Kerry S. Courneya ◽

Catherine J. Field ◽

John R. Mackey

Keyword(s):

Immune System ◽

Physical Exercise ◽

Cancer Survivors ◽

System Function ◽

Immune System Function

Download Full-text

In utero cell transfer between porcine littermates

Reproduction Fertility and Development ◽

10.1071/rd10165 ◽

2011 ◽

Vol 23 (2) ◽

pp. 297 ◽

Cited By ~ 13

Author(s):

Andrea McConico ◽

Kim Butters ◽

Karen Lien ◽

Bruce Knudsen ◽

Xiaosheng Wu ◽

...

Keyword(s):

Immune System ◽

Cord Blood ◽

Normal Pregnancy ◽

Human Cells ◽

Cell Transfer ◽

System Function ◽

Human Cord Blood ◽

Immune System Function ◽

Vascular Connections

Trafficking of cells between mother and fetus during the course of normal pregnancy is well documented. Similarly, cells are known to travel between twins that share either a placenta (i.e. monozygotic) or associated chorion (i.e. monochorionic). Transferred cells are thought to be channelled via the vessels of the placenta or vascular connections established via the chorion and the long-term presence of these cells (i.e. microchimerism) can have important consequences for immune system function and reparative capacity of the host. Whether cells can be transferred between twins with separate placentas and separate chorions (i.e. no vascular connections between placentas) has not been investigated nor have the biological consequences of such a transfer. In the present study, we tested the possibility of this type of cell transfer by injecting human cord blood-derived cells into a portion of the littermates of swine and probing for human cells in the blood and tissues of unmanipulated littermates. Human cells were detected in the blood of 78% of unmanipulated littermates. Human cells were also detected in various tissues of the unmanipulated littermates, including kidney (56%), spleen (33%), thymus (11%) and heart (22%). Human cells were maintained in the blood until the piglets were sacrificed (8 months after birth), suggesting the establishment of long-term microchimerism. Our findings show that the transfer of cells between fetuses with separate placentas and separate chorions is significant and thus such twins may be subject to the same consequences of microchimerism as monozygotic or monochorionic counterparts.

Download Full-text