Full Screen Digital Image CCD Chip Transnasal Esophagoscopy with Disposable Endosheath (TNE/DE) Is Superior to ESO Pillcam (ESO) As Screening Tool for Esophageal Pathology

2008 ◽  
Vol 67 (5) ◽  
pp. AB123
Author(s):  
Mark D. Noar
Keyword(s):  
Digital Image ◽  
Screening Tool ◽  
Transnasal Esophagoscopy ◽  
Full Screen ◽  
Esophageal Pathology

Transnasal Esophagoscopy Findings: Interspecialty Comparison

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P51-P51
Author(s):  
Michael T Falcone ◽  
C Gaelyn Garrett ◽  
Michael Fredrick Vaezi ◽  
Robert H Ossoff ◽  
James Christopher Slaughter ◽  
...  
Keyword(s):  
Hiatal Hernia ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Esophageal Stricture ◽  
Interdisciplinary Approach ◽  
Transnasal Esophagoscopy ◽  
Percent Agreement ◽  
Inter Observer Variability ◽  
Kappa Value ◽  
Esophageal Pathology

Objective Otolaryngologists implement transnasal esophagoscopy (TNE) to assess esophageal pathology. Previous studies using TNE to evaluate esophageal pathology have been limited in various ways. These are largely retrospective and deal with select patient populations. There are currently no data on the prevalence of esophageal pathology in “all comers” to an otolaryngology voice center. The objectives are to assess the prevalence of esophageal pathology in this population and determine the inter-observer variability of the findings reviewed by an otolaryngologist and a gastroenterologist. Methods Consecutive patients with throat symptoms presenting to the voice center were asked to undergo TNE. The findings were videotaped and reviewed by an otolaryngologist and a gastroesophagologist blinded to the patients’ presenting complaint. Results 50 patients were selected prospectively to undergo TNE. Hoarseness was the most common presenting symptom (68%). According to the gastroesophagologist, the prevalence of esophageal findings was: Barrett's esophagus (12%), esophagitis (10%), hiatal hernia (32%), and esophageal stricture (10%). The percent agreement for a normal study was 72% (kappa 0.44). The percent agreement (kappa value) for various pathologic findings are as follows: Barrett's esophagus, 86% (0.45); esophagitis, 88% (0.43); hiatal hernia, 76% (0.39); and esophageal stricture, 96% (0.73). The frequency of an exact agreement between raters was 54%. For an abnormal study, the percent agreement was 80%. The reviewers were 7.11 times more likely to agree than disagree (p = 0.002). Conclusions Esophageal abnormalities are common in patients presenting to a voice subspecialty clinic. An interdisciplinary approach can provide this population with complementary patient care.

scholarly journals Dermal Penetration Analysis of Curcumin in an ex vivo Porcine Ear Model Using Epifluorescence Microscopy and Digital Image Processing

2021 ◽  
pp. 1-19
Author(s):  
Olga Pelikh ◽  
Shashank R. Pinnapireddy ◽  
Cornelia M. Keck
Keyword(s):  
Digital Image ◽  
Screening Tool ◽  
Therapeutic Potential ◽  
Ex Vivo ◽  
Skin Penetration ◽  
Aqueous Solubility ◽  
Epifluorescence Microscopy ◽  
Drug Candidate ◽  
Standard Formulation ◽  
Dermal Penetration

<b><i>Introduction:</i></b> Curcumin is a promising drug candidate, but its use for dermal application is limited due to its poor aqueous solubility. Thus, formulations that increase the solubility of curcumin are needed to fully exploit the therapeutic potential of curcumin. Various previous studies address this issue, but a comparison of the efficacy between these formulations remains difficult. The reason for this is a missing standard formulation as benchmark control and an easy-to-use skin penetration model that allows for a fast discrimination between different formulations. <b><i>Objective:</i></b> Thus, the aims of this study were the development of a curcumin standard formulation and a screening tool that allows for a fast discrimination between the dermal penetration efficacies of curcumin from different formulations. <b><i>Methods:</i></b> Ethanolic curcumin solutions were selected as simple and easy to produce standard formulations, and the ex vivo porcine ear model, coupled with epifluorescence microscopy and subsequent digital image analysis, was utilized to determine the dermal penetration efficacy of curcumin from the different formulations. <b><i>Results:</i></b> Results show that the utilized skin penetration model is a suitable and versatile tool that enables not only a fast determination of the dermal penetration efficacy of curcumin from different formulations but also a detailed and mechanistic information on the fate of chemical compounds after dermal penetration. Ethanolic solutions containing 0.25% curcumin were found to be the most suitable standard formulation. <b><i>Conclusions:</i></b> Results of the study provide a new, effective screening tool for the development of dermal formulations for improved dermal delivery of curcumin.

An Overview of Digital Image Processing and Recognition (Invited Paper)

1982 ◽  
Vol 40 ◽  
pp. 700-702
Author(s):  
R. C. Gonzalez
Keyword(s):  
Image Processing ◽  
New York ◽  
Digital Image Processing ◽  
Digital Image ◽  
Practical Implementation ◽  
Submarine Cable ◽  
Vigorous Growth ◽  
Digitized Pictures ◽  
Processing Techniques ◽  
And Storage

Interest in digital image processing techniques dates back to the early 1920's, when digitized pictures of world news events were first transmitted by submarine cable between New York and London. Applications of digital image processing concepts, however, did not become widespread until the middle 1960's, when third-generation digital computers began to offer the speed and storage capabilities required for practical implementation of image processing algorithms. Since then, this area has experienced vigorous growth, having been a subject of interdisciplinary research in fields ranging from engineering and computer science to biology, chemistry, and medicine.

A method to measure pores and fissures in geologic materials under S.E.M. by digital image processing

1978 ◽  
Vol 36 (1) ◽  
pp. 212-213
Author(s):  
L. Montoto ◽  
M. Montoto ◽  
A. Bel-Lan
Keyword(s):  
Image Processing ◽  
Optical Microscopy ◽  
Digital Image Processing ◽  
Digital Image ◽  
Digital Processing ◽  
Free Surfaces ◽  
Geologic Materials ◽  
Automatic Information ◽  
Detector Output ◽  
Rock Specimens

INTRODUCTION.- The physical properties of rock masses are greatly influenced by their internal discontinuities, like pores and fissures. So, these need to be measured as a basis for interpretation. To avoid the basic difficulties of measurement under optical microscopy and analogic image systems, the authors use S.E.M. and multiband digital image processing. In S.E.M., analog signal processing has been used to further image enhancement (1), but automatic information extraction can be achieved by simple digital processing of S.E.M. images (2). The use of multiband image would overcome difficulties such as artifacts introduced by the relative positions of sample and detector or the typicals encountered in optical microscopy.DIGITAL IMAGE PROCESSING.- The studied rock specimens were in the form of flat deformation-free surfaces observed under a Phillips SEM model 500. The SEM detector output signal was recorded in picture form in b&w negatives and digitized using a Perkin Elmer 1010 MP flat microdensitometer.

Digital image processing methods applied to the study of annealing time on semiconductor-metal eutectic composites

1988 ◽  
Vol 46 ◽  
pp. 848-849
Author(s):  
J. Hefter
Keyword(s):  
Image Processing ◽  
Digital Image Processing ◽  
Digital Image ◽  
Electronic Device ◽  
Processing System ◽  
Average Diameter ◽  
Eutectic Solidification ◽  
Metal Silicide ◽  
The Matrix ◽  
Microscopic Studies

Semiconductor-metal composites, formed by the eutectic solidification of silicon and a metal silicide have been under investigation for some time for a number of electronic device applications. This composite system is comprised of a silicon matrix containing extended metal-silicide rod-shaped structures aligned in parallel throughout the material. The average diameter of such a rod in a typical system is about 1 μm. Thus, characterization of the rod morphology by electron microscope methods is necessitated.The types of morphometric information that may be obtained from such microscopic studies coupled with image processing are (i) the area fraction of rods in the matrix, (ii) the average rod diameter, (iii) an average circularity (roundness), and (iv) the number density (Nd;rods/cm2). To acquire electron images of these materials, a digital image processing system (Tracor Northern 5500/5600) attached to a JEOL JXA-840 analytical SEM has been used.

Complementary Z-Contrast Imaging and Digital Image Processing

1985 ◽  
Vol 43 ◽  
pp. 304-305
Author(s):  
K. N. Colonna ◽  
G. Oliphant
Keyword(s):  
Image Processing ◽  
Heavy Metal ◽  
Digital Image Processing ◽  
Digital Image ◽  
Biological Tissue ◽  
Biological Imaging ◽  
Tissue Preparation ◽  
Contrast Imaging ◽  
Imaging Tool ◽  
Z Contrast

Harmonious use of Z-contrast imaging and digital image processing as an analytical imaging tool was developed and demonstrated in studying the elemental constitution of human and maturing rabbit spermatozoa. Due to its analog origin (Fig. 1), the Z-contrast image offers information unique to the science of biological imaging. Despite the information and distinct advantages it offers, the potential of Z-contrast imaging is extremely limited without the application of techniques of digital image processing. For the first time in biological imaging, this study demonstrates the tremendous potential involved in the complementary use of Z-contrast imaging and digital image processing.Imaging in the Z-contrast mode is powerful for three distinct reasons, the first of which involves tissue preparation. It affords biologists the opportunity to visualize biological tissue without the use of heavy metal fixatives and stains. For years biologists have used heavy metal components to compensate for the limited electron scattering properties of biological tissue.

Digital image acquisition, processing, and analysis in a polymer microscopy laboratory

1994 ◽  
Vol 52 ◽  
pp. 454-455
Author(s):  
Vinod K. Berry ◽  
Xiao Zhang
Keyword(s):  
United States ◽  
Image Analysis ◽  
Digital Image ◽  
Image Acquisition ◽  
Image Transmission ◽  
The United States ◽  
Quantitative Image Analysis ◽  
Quantitative Image

In recent years it became apparent that we needed to improve productivity and efficiency in the Microscopy Laboratories in GE Plastics. It was realized that digital image acquisition, archiving, processing, analysis, and transmission over a network would be the best way to achieve this goal. Also, the capabilities of quantitative image analysis, image transmission etc. available with this approach would help us to increase our efficiency. Although the advantages of digital image acquisition, processing, archiving, etc. have been described and are being practiced in many SEM, laboratories, they have not been generally applied in microscopy laboratories (TEM, Optical, SEM and others) and impact on increased productivity has not been yet exploited as well.In order to attain our objective we have acquired a SEMICAPS imaging workstation for each of the GE Plastic sites in the United States. We have integrated the workstation with the microscopes and their peripherals as shown in Figure 1.

A basic introduction to image processing using NIH-Image as a model

1994 ◽  
Vol 52 ◽  
pp. 392-393
Author(s):  
John Mansfield
Keyword(s):  
Image Processing ◽  
Digital Image ◽  
Image Acquisition ◽  
Digital Instrument ◽  
Novice User ◽  
Nih Image ◽  
The Past ◽  
Digital World ◽  
The World ◽  
Instrument Control

Advances in camera technology and digital instrument control have meant that in modern microscopy, the image that was, in the past, typically recorded on a piece of film is now recorded directly into a computer. The transfer of the analog image seen in the microscope to the digitized picture in the computer does not mean, however, that the problems associated with recording images, analyzing them, and preparing them for publication, have all miraculously been solved. The steps involved in the recording an image to film remain largely intact in the digital world. The image is recorded, prepared for measurement in some way, analyzed, and then prepared for presentation.Digital image acquisition schemes are largely the realm of the microscope manufacturers, however, there are also a multitude of “homemade” acquisition systems in microscope laboratories around the world. It is not the mission of this tutorial to deal with the various acquisition systems, but rather to introduce the novice user to rudimentary image processing and measurement.

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