Sa1618 Natural History of Gastrointestinal Stromal Tumors (GISTs)

2011 ◽  
Vol 73 (4) ◽  
pp. AB225
Author(s):  
Teruko Tomono ◽  
Akira Sawaki ◽  
Kenji Yamao
Keyword(s):  
Natural History ◽  
Gastrointestinal Stromal Tumors ◽  
Stromal Tumors ◽  
History Of

scholarly journals Multiple Gastric Gastrointestinal Stromal Tumors in a Patient with Neurofibromatosis Type 1

2016 ◽  
Vol 2016 ◽  
pp. 1-5
Author(s):  
Makoto Tomatsu ◽  
Jun Isogaki ◽  
Takahiro Watanabe ◽  
Kiyoshige Yajima ◽  
Takuya Okumura ◽  
...  
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Gastrointestinal Stromal Tumors ◽  
Kinase Inhibitor ◽  
Submucosal Tumor ◽  
Neurofibromatosis Type ◽  
Stromal Tumors ◽  
Serosal Surface ◽  
History Of ◽  
Small Intestinal

Gastrointestinal stromal tumors (GISTs) are relatively common in neurofibromatosis type 1 (NF 1) patients. Approximately 90% of GISTs associated with NF 1 are located in the small intestine, while sporadic GISTs are most commonly located in the stomach. Here we report an extremely rare case of an NF 1 patient with multiple gastric GITs (90 or more) but without multiple small intestinal tumors. A 63-year-old female patient who had a history of NF 1 underwent surgery for a gastric neuroendocrine tumor and gastric submucosal tumor (SMT). During the operation, multiple small nodules were identified on the serosal surface of the upper stomach. SMT and multiple nodules on the serosal surface were diagnosed as GISTs consisting of spindle cells positive for KIT, CD34, and DOG-1. Both GIST and the normal gastric mucosa showed no mutations not only in the c-kitgene (exons 8, 9, 11, 13, and 17) but also in thePDGFRAgene (exons 12, 14, and 18). This patient is being followed up without the administration of a tyrosine kinase inhibitor.

scholarly journals Clinical course, diagnosis and treatment of gastrointestinal stromal tumors

2011 ◽  
Vol 3 (1) ◽  
pp. 59-64
Author(s):  
Yulyi V. Ivanov
Keyword(s):  
Prognostic Factors ◽  
Gastrointestinal Tract ◽  
Case History ◽  
Gastrointestinal Stromal Tumors ◽  
Clinical Course ◽  
Target Therapy ◽  
Diagnosis And Treatment ◽  
Successful Operation ◽  
Stromal Tumors ◽  
History Of

The article summarizes up-to-date data of the pathogenesis, diagnosis, and treatment conceptions of the stromal tumors of gastrointestinal tract (GIST). Prognostic factors for progression (recurrence or metastasis) for GIST are reported. Special attention is given to immuno-histochemical method of diagnostics and target therapy for these kinds of tumors. We present the case history of successful operation in a patient with giant intestinal stromal tumor of the stomach, sprouting into neighbouring organs and tissues.

scholarly journals Massive Multifocal Familial GIST: A Case Report

2021 ◽  
pp. 1-4
Author(s):  
Steven Craig ◽  
Samuel R Thomson ◽  
Su Ang ◽  
Steven Craig
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Germline Mutations ◽  
Long Term Outcomes ◽  
Stromal Tumors ◽  
Mesenchymal Neoplasms ◽  
Younger Age ◽  
Mild Abdominal Pain ◽  
History Of ◽  
Base Management

Gastrointestinal stromal tumors (GIST) are uncommon mesenchymal neoplasms of the gastrointestinal tract. The majority of GISTs are the result of sporadic mutations, most commonly of the KIT proto-oncogene. Germline mutations account for 5% of GISTs and result in rare familial syndromes. We present a 66-year-old male with a family history of GIST who presented with mild abdominal pain and was found to have a massive, multifocal GIST. The main tumor was resected via laparotomy and the weight was found over 2 kg. He was commenced on adjuvant therapy with imatinib and will be closely monitored. Familial GISTs tend to be larger, multifocal and diagnosed at a younger age. Familial GISTs are extremely rare conditions. There is little to no evidence on the long-term outcomes of treatment on which to base management decisions.

scholarly journals Anesthetic Considerations in a Patient With Plexiform Neurofibromatosis: A Case Report

2018 ◽  
Vol 5 (4) ◽  
pp. 169-170
Author(s):  
Pardis Soltanpoor ◽  
Faranak Behnaz ◽  
Mehdi Farokhi ◽  
Reza Jalili Khoshnood ◽  
Hamid Reza Azizi Farsani
Keyword(s):  
Gastrointestinal Stromal Tumors ◽  
Plexiform Neurofibroma ◽  
Neurofibromatosis Type ◽  
Stromal Tumors ◽  
Anesthetic Considerations ◽  
Plexiform Neurofibromatosis ◽  
History Of ◽  
The Brain ◽  
Other Neoplasms

Plexiform neurofibromatosis is an uncommon variant of neurofibromatosis type 1 (NF1) (Von Recklinghausen’s disease). There is a greater prevalence of neurofibromatosis 1 in patients with other neoplasms, such as rhabdomyosarcomas, gastrointestinal stromal tumors (GISTs), pheochromocytomas, carcinoid tumors and ganglioneuromas. We report the anesthetic implications of a case of a 33 year old patient with plexiform neurofibromatosis and a history of pheochromocytoma which was operated on previously. He presented with painless swelling on upper eye-lead since childhood and had multiple caféau-lait spots and neurofibromas on the trunk. The surgery was done in two sessions first on the plexiform neurofibroma of the eye followed by the operation on the brain mass.

scholarly journals Co-Incidence of Paraesophageal Hernia and Perforated Gastrointestinal Stromal Tumor: A Case Report on Rare Presentation of GIST

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Majid Samsami ◽  
Mohammad Rafiei ◽  
Aida Saki ◽  
Parham Nikraftar
Keyword(s):  
Abdominal Pain ◽  
Gastrointestinal Stromal Tumors ◽  
Paraesophageal Hernia ◽  
Rare Complication ◽  
Subtotal Gastrectomy ◽  
Rare Presentation ◽  
Case Presentation ◽  
Stromal Tumors ◽  
History Of ◽  
Distended Stomach

Introduction: The most common connective tissue neoplasm of the gastrointestinal tract is gastrointestinal stromal tumors (GISTs). Its presentations are usually abdominal pain and gastrointestinal bleeding. Case Presentation: We report a 31-year-old man with abdominal pain presented to our hospital with 10 days history of abdominal pain. After radiologic investigations, total distended stomach paraesophageal hernia and antral deformity were seen in the CT scan. Subsequently, the patient underwent surgery and after releasing the stomach, a large sealed perforated mass was seen in the antrum near the diaphragmatic hiatus and small localized abscess that subtotal gastrectomy and hernia repair was done. Pathologic examination revealed that the perforated mass is a GIST. Conclusions: We report a rare complication of gist that is perforation and the first report of simultaneous paraesophageal hernia and perforated gist.

How is the moral stance related to the intentional stance and group thinking?

2020 ◽  
Vol 43 ◽  
Author(s):  
Hannes Rakoczy
Keyword(s):  
Natural History ◽  
Social Cognitive ◽  
Intentional Stance ◽  
Cognitive Capacities ◽  
Shared Intentionality ◽  
History Of ◽  
Group Thinking ◽  
Moral Stance

Abstract The natural history of our moral stance told here in this commentary reveals the close nexus of morality and basic social-cognitive capacities. Big mysteries about morality thus transform into smaller and more manageable ones. Here, I raise questions regarding the conceptual, ontogenetic, and evolutionary relations of the moral stance to the intentional and group stances and to shared intentionality.

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