Our Lady of Guadalupe is the only Marian apparition tradition in the Americas—and indeed in all of Roman Catholicism—that inspired a sustained series of published theological analyses. Theologians in each successive epoch since the mid-seventeenth century have plumbed the meaning of Guadalupe for their times. Their theological works are grounded in two realities: the first is the relationship between Guadalupe and her faithful, and the second is her power to shape their lives and their world. Theologies of Guadalupe examines the way theologians have understood Guadalupe and sought to orient her impact in the lives of her devotees. It also examines Guadalupe’s meaning in everyday devotees’ lives and the spread of Guadalupan devotion over nearly half a millennium. Chapters of this study successively examine core theological topics in the Guadalupe tradition developed in response to major events of Mexican history: conquest, attempts to Christianize native peoples, society building, independence, and the demands for justice of marginalized groups. The successive chapters also narrate how, amid the plentiful miraculous images of Christ, Mary, and the saints that dotted the sacred landscape of colonial New Spain, the Guadalupe cult rose above all others and emerged from a local devotion to become a regional, national, and then international phenomenon. From patristic-based theological writings in the colonial era down to contemporary formulations shaped by the emergence of liberation theologies in Latin America, the theologies under study here reveal how Christian concepts and scriptures imported from Europe developed in dynamic interaction with the new contexts in which they took root.