Incidence of Ischaemic Heart Disease in Men and Women With End-Stage Kidney Disease: A Cohort Study

2020 ◽  
Vol 29 (10) ◽  
pp. 1517-1526 ◽  
Author(s):  
Emma O'Lone ◽  
Patrick J. Kelly ◽  
Philip Masson ◽  
Sradha Kotwal ◽  
Martin Gallagher ◽  
...  
2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii179-iii179
Author(s):  
Philip Masson ◽  
Sradha Kotwal ◽  
Patrick J Kelly ◽  
Jonathan C Craig ◽  
Richard I Lindley ◽  
...  

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Axelsson Raja ◽  
Peder E. Warming ◽  
Ture L. Nielsen ◽  
Louis L. Plesner ◽  
Mads Ersbøll ◽  
...  

Abstract Background Cardiovascular disease is the most common cause of death in patients with end-stage kidney disease on haemodialysis. The potential clinical consequence of systematic echocardiographic assessment is however not clear. In an unselected, contemporary population of patients on maintenance haemodialysis we aimed to assess: the prevalence of structural and functional heart disease, the potential therapeutic consequences of echocardiographic screening and whether left-sided heart disease is associated with prognosis. Methods Adult chronic haemodialysis patients in two large dialysis centres had transthoracic echocardiography performed prior to dialysis and were followed prospectively. Significant left-sided heart disease was defined as moderate or severe left-sided valve disease or left ventricular ejection fraction (LVEF) ≤40%. Results Among the 247 included patients (mean 66 years of age [95%CI 64–67], 68% male), 54 (22%) had significant left-sided heart disease. An LVEF ≤40% was observed in 31 patients (13%) and severe or moderate valve disease in 27 (11%) patients. The findings were not previously recognized in more than half of the patients (56%) prior to the study. Diagnosis had a potential impact on management in 31 (13%) patients including for 18 (7%) who would benefit from initiation of evidence-based heart failure therapy. After 2.8 years of follow-up, all-cause mortality among patients with and without left-sided heart disease was 52 and 32% respectively (hazard ratio [HR] 1.95 (95%CI 1.25–3.06). A multivariable adjusted Cox proportional hazard analysis showed that left-sided heart disease was an independent predictor of mortality with a HR of 1.60 (95%CI 1.01–2.55) along with age (HR per year 1.05 [95%CI 1.03–1.07]). Conclusion Left ventricular systolic dysfunction and moderate to severe valve disease are common and often unrecognized in patients with end-stage kidney failure on haemodialysis and are associated with a higher risk of death. For more than 10% of the included patients, systematic echocardiographic assessment had a potential clinical consequence.


PLoS Medicine ◽  
2019 ◽  
Vol 16 (10) ◽  
pp. e1002977
Author(s):  
Ali S. Khashan ◽  
Marie Evans ◽  
Marius Kublickas ◽  
Fergus P. McCarthy ◽  
Louise C. Kenny ◽  
...  

2016 ◽  
Vol 31 (3) ◽  
pp. 283-288 ◽  
Author(s):  
Natasha Lovell ◽  
Chris Jones ◽  
Dawn Baynes ◽  
Sarah Dinning ◽  
Katie Vinen ◽  
...  

Background: Meeting place-of-death preferences is an important measure of the quality of end-of-life care. Systematic review shows that 42% of end-stage kidney disease patients prefer home death. Little research has been undertaken on place of death. Aim: To understand patterns of place of death in patients with end-stage kidney disease known in one UK renal unit. Design: A retrospective cohort study of all patients with chronic kidney disease stage 4–5, age ⩾75 and known to one UK renal unit, who died between 2006 and 2012. Patients were categorised into three management pathways: haemodialysis, conservative and pre-dialysis. Results: A total of 321 patients (mean age, 82.7; standard deviation, 5.21) died (61.7% male). In all, 62.9% died in hospital (95% confidence interval, 57.5%–68.1%), 21.8% died in their usual place of residence (95% confidence interval, 17.5%–26.6%) and 15.3% died in an inpatient palliative care unit (95% confidence interval, 11.6%–19.5%). Management pathway and living circumstances were most strongly associated with place of death. Patients on the conservative pathway had four times the odds of dying out of hospital (odds ratio, 4.0; 95% confidence interval, 2.1–7.5; p < 0.01). Patients living alone were less likely to die out of hospital (odds ratio, 0.3; 95% confidence interval, 0.1–0.6; p < 0.01). There were also changes in place of death over time, with more patients dying out of hospital in 2012 compared to 2006 (odds ratio, 3.1; 95% confidence interval, 1.0–9.7; p < 0.05). Conclusion: Most patients with end-stage kidney disease die in hospital, but patients managed without dialysis are significantly more likely to die outside of hospital. Planning ahead is key to be able to meet preference for place of death.


2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii57-iii57
Author(s):  
Philip Masson ◽  
Patrick J Kelly ◽  
Jonathan C Craig ◽  
Richard I Lindley ◽  
Angela C Webster

BMJ ◽  
1998 ◽  
Vol 317 (7153) ◽  
pp. 241-245 ◽  
Author(s):  
D. A Leon ◽  
H. O Lithell ◽  
D. Vagero ◽  
I. Koupilova ◽  
R. Mohsen ◽  
...  

Author(s):  
Kristine Fogh ◽  
Søren Viborg Vestergaard ◽  
Christian Fynbo Christiansen ◽  
Lars Pedersen ◽  
Dorothea Nitsch ◽  
...  

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