A comparative study on renal biopsy before and after long-term calcineurin inhibitors therapy: an insight for pathogenesis of its toxicity

2015 ◽  
Vol 46 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Lavleen Singh ◽  
Geetika Singh ◽  
Alok Sharma ◽  
Aditi Sinha ◽  
Arvind Bagga ◽  
...  
2020 ◽  
Vol 47 (47) ◽  
pp. 115-131
Author(s):  
Thecla Iheoma Akukwe ◽  
Alice Atieno Oluoko-Odingo ◽  
George Okoye Krhoda

AbstractA comparative study of pre- and post-flood households’ food security statuses in South-Eastern Nigeria was performed to answer the question “Do floods affect food security?” Data were generated via a survey of 400 households in eight communities using stratified and random sampling methods. Households’ food security statuses were assessed using the Household Food Security Survey Module (HFSSM) and computed using a Rasch analysis, where households were divided into four categories, namely: food secure, food insecure without hunger, moderately food insecure with hunger and severely food insecure with hunger. The results show that flooding affects food security negatively by increasing the number of food insecure households to 92.8%, and the regression coefficient of −0.798 indicates a very strong negative effect of flooding on household food security. An odds ratio of 2.221 implies that households that have experienced flooding are 2.221 times more probable to be food insecure than households that have not. The implication of the findings is that flooding is capable of turning communities into food insecurity hotspots that would need long-term assistance to cope, and flooding is capable of hampering the achievement of Goal 2 of the SDGs.


2020 ◽  
Vol 6 (1) ◽  
pp. 55-60
Author(s):  
Khabib Barnoev ◽  
◽  
Sherali Toshpulatov ◽  
Nozima Babajanova ◽  

The article presents the results of a study to evaluate the effectiveness of antiaggregant therapy on the functional status of the kidneys in 115 patients with stage II and III chronic kidney disease on the basis of a comparative study of dipyridamole and allthrombosepin. Studies have shown that long-term administration of allthrombosepin to patients has led to improved renal function.


2020 ◽  
Vol 6 (1) ◽  
pp. 49-54
Author(s):  
Khabib Barnoev ◽  

The article presents the results of a study to assess the functional reserve of the kidneys against the background of a comparative study of antiaggregant therapy dipyridamole and allthrombosepin in 50 patients with a relatively early stage of chronic kidney disease. Studies have shown that long-term administration of allthrombosepin to patients has resulted in better maintenance of kidney functional reserves. Therefore, our research has once again confirmed that diphtheridamol, which is widely used as an antiaggregant drug in chronic kidney disease, does not lag behind the domestic raw material allthrombosepin


2020 ◽  
Vol 25 (4) ◽  
pp. 323-330
Author(s):  
E. S. Ovcharenko ◽  
V. V. Erichev ◽  
S. I. Risovannij ◽  
T. V. Aksenova ◽  
S. V. Melekhov ◽  
...  

Relevance. A long-term inflammation in the oral cavity, unreasonable treatment of periodontal patients with antibiotics cause imbalance between certain types of fungal-bacterial associations accompanied by oral dysbiosis and change of local immune status. So, development and application of new comprehensive diagnosis and treatment techniques in periodontal patients, use of products for correction of microbiota and local immunity are a current and a long-term task. Purpose is to optimize the comprehensive treatment protocol of inflammatory periodontal diseases by introducing probiotics and evaluation of oral microbiome and cytokine profile.Materials and methods. 140 patients were examined. Of these 60 patients had chronic generalized plaque-induced gingivitis and 60 patients suffered from moderate chronic generalized periodontitis. Bacterial and fungal microbiome was assessed and the host immune response was evaluated in all patients before and after the treatment. Half of the patients were treated conventionally and the other half were treated according to a modified scheme: probiotic “Bifidumbacterin Forte” was added.Results. A large number of yeast-like fungi Candida and commensal bacteria were detected in periodontal pockets of patients with chronic generalized plaque-induced gingivitis and moderate chronic generalized periodontitis. That correlates with a significant increase of pro-inflammatory cytokines (TNF-α, IL—8), decrease of concentration of INF-γ and increase of antiinflammatory cytokine IL-4.Conclusion. Changes in clinical, microbiological and immunological values during a modified combination therapy with a probiotic and during a conventional treatment demonstrated that effectiveness of treatment of chronic gingivitis and chronic periodontitis increased by 40% and 37% respectively.


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