scholarly journals Large-scale electrophysiology with Neuropixels: Scientific advances and future directions

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S43
Author(s):  
Nicholas Steinmetz
Technologies ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 2
Author(s):  
Ashish Jaiswal ◽  
Ashwin Ramesh Babu ◽  
Mohammad Zaki Zadeh ◽  
Debapriya Banerjee ◽  
Fillia Makedon

Self-supervised learning has gained popularity because of its ability to avoid the cost of annotating large-scale datasets. It is capable of adopting self-defined pseudolabels as supervision and use the learned representations for several downstream tasks. Specifically, contrastive learning has recently become a dominant component in self-supervised learning for computer vision, natural language processing (NLP), and other domains. It aims at embedding augmented versions of the same sample close to each other while trying to push away embeddings from different samples. This paper provides an extensive review of self-supervised methods that follow the contrastive approach. The work explains commonly used pretext tasks in a contrastive learning setup, followed by different architectures that have been proposed so far. Next, we present a performance comparison of different methods for multiple downstream tasks such as image classification, object detection, and action recognition. Finally, we conclude with the limitations of the current methods and the need for further techniques and future directions to make meaningful progress.


Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1030
Author(s):  
Julie Lake ◽  
Catherine S. Storm ◽  
Mary B. Makarious ◽  
Sara Bandres-Ciga

Neurodegenerative diseases are etiologically and clinically heterogeneous conditions, often reflecting a spectrum of disease rather than well-defined disorders. The underlying molecular complexity of these diseases has made the discovery and validation of useful biomarkers challenging. The search of characteristic genetic and transcriptomic indicators for preclinical disease diagnosis, prognosis, or subtyping is an area of ongoing effort and interest. The next generation of biomarker studies holds promise by implementing meaningful longitudinal and multi-modal approaches in large scale biobank and healthcare system scale datasets. This work will only be possible in an open science framework. This review summarizes the current state of genetic and transcriptomic biomarkers in Parkinson’s disease, Alzheimer’s disease, and amyotrophic lateral sclerosis, providing a comprehensive landscape of recent literature and future directions.


2011 ◽  
Vol 20 (2) ◽  
pp. 121-126 ◽  
Author(s):  
D. Fowler ◽  
R. Rollinson ◽  
P. French

All good quality trials of psychological interventions need to check formally that therapists have used the techniques prescribed in the published therapy manuals, and that the therapy has been carried out competently. This paper reviews methods of assessing adherence and competence used in recent large-scale trials of Cognitive Behaviour Therapy (CBT) for psychosis in the UK carried out by our research groups. A combination of the Cognitive Therapy Rating Scale and specific versions of the Cognitive Therapy for Psychosis Adherence Scales provides an optimal assessment of adherence and competence. Careful assessment of the competence and adherence can help identify the procedures actually carried out with individuals within trials. The basic use of such assessments is to provide an external check on treatment fidelity on a sample of sessions. Such assessment can also provide the first step towards moving research towards making sense of CBT for psychosis as a complex intervention and identifying which techniques work for which problems of people with psychosis, at which stages of disorder?


2007 ◽  
Vol 133 (4) ◽  
pp. 581-624 ◽  
Author(s):  
Robert J. Gatchel ◽  
Yuan Bo Peng ◽  
Madelon L. Peters ◽  
Perry N. Fuchs ◽  
Dennis C. Turk

2021 ◽  
Vol 11 ◽  
Author(s):  
Yorgui Santiago-Andres ◽  
Matan Golan ◽  
Tatiana Fiordelisio

The pituitary is a master endocrine gland that developed early in vertebrate evolution and therefore exists in all modern vertebrate classes. The last decade has transformed our view of this key organ. Traditionally, the pituitary has been viewed as a randomly organized collection of cells that respond to hypothalamic stimuli by secreting their content. However, recent studies have established that pituitary cells are organized in tightly wired large-scale networks that communicate with each other in both homo and heterotypic manners, allowing the gland to quickly adapt to changing physiological demands. These networks functionally decode and integrate the hypothalamic and systemic stimuli and serve to optimize the pituitary output into the generation of physiologically meaningful hormone pulses. The development of 3D imaging methods and transgenic models have allowed us to expand the research of functional pituitary networks into several vertebrate classes. Here we review the establishment of pituitary cell networks throughout vertebrate evolution and highlight the main perspectives and future directions needed to decipher the way by which pituitary networks serve to generate hormone pulses in vertebrates.


2020 ◽  
Vol 34 (05) ◽  
pp. 7554-7561
Author(s):  
Pengxiang Cheng ◽  
Katrin Erk

Recent progress in NLP witnessed the development of large-scale pre-trained language models (GPT, BERT, XLNet, etc.) based on Transformer (Vaswani et al. 2017), and in a range of end tasks, such models have achieved state-of-the-art results, approaching human performance. This clearly demonstrates the power of the stacked self-attention architecture when paired with a sufficient number of layers and a large amount of pre-training data. However, on tasks that require complex and long-distance reasoning where surface-level cues are not enough, there is still a large gap between the pre-trained models and human performance. Strubell et al. (2018) recently showed that it is possible to inject knowledge of syntactic structure into a model through supervised self-attention. We conjecture that a similar injection of semantic knowledge, in particular, coreference information, into an existing model would improve performance on such complex problems. On the LAMBADA (Paperno et al. 2016) task, we show that a model trained from scratch with coreference as auxiliary supervision for self-attention outperforms the largest GPT-2 model, setting the new state-of-the-art, while only containing a tiny fraction of parameters compared to GPT-2. We also conduct a thorough analysis of different variants of model architectures and supervision configurations, suggesting future directions on applying similar techniques to other problems.


2009 ◽  
Vol 6 (4) ◽  
pp. 6441-6489 ◽  
Author(s):  
S. Duggen ◽  
N. Olgun ◽  
P. Croot ◽  
L. Hoffmann ◽  
H. Dietze ◽  
...  

Abstract. Iron is a key micronutrient for phytoplankton growth in the surface ocean. Yet the significance of volcanism for the marine biogeochemical iron-cycle is poorly constrained. Recent studies, however, suggest that offshore deposition of airborne ash from volcanic eruptions is a way to inject significant amounts of bio-available iron into the surface ocean. Volcanic ash may be transported up to several tens of kilometres high into the atmosphere during large-scale eruptions and fine ash may encircle the globe for years, thereby reaching even the remotest and most iron-starved oceanic areas. Scientific ocean drilling demonstrates that volcanic ash layers and dispersed ash particles are frequently found in marine sediments and that therefore volcanic ash deposition and iron-injection into the oceans took place throughout much of the Earth's history. The data from geochemical and biological experiments, natural evidence and satellite techniques now available suggest that volcanic ash is a so far underestimated source for iron in the surface ocean, possibly of similar importance as aeolian dust. Here we summarise the development of and the knowledge in this fairly young research field. The paper covers a wide range of chemical and biological issues and we make recommendations for future directions in these areas. The review paper may thus be helpful to improve our understanding of the role of volcanic ash for the marine biogeochemical iron-cycle, marine primary productivity and the ocean-atmosphere exchange of CO2 and other gases relevant for climate throughout the Earth's history.


2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Yvkai Zhang

Assistive technology and evaluation system are expected to effectively solve the challenges of using robots in construction activities and improve the efficiency and building performance. Still, challenges are still need to be addressed before using robots for construction on a large scale. This Studies were corresponded to the identified areas for further critical review, and the development of research and application in each area was systematically analyzed to identify future directions for both the academia and the industry. More speci?cally, this review focus on determining the requirement of technology and application profile for robots, and based on the above analysis, a complete set of construction framework for robot was proposed, which integrates robots and activities with the various modular systems and digital technology to get global optimum solution.


Author(s):  
Kristel K. Leung ◽  
Maya Deeb ◽  
Sandra E. Fischer ◽  
Aliya Gulamhusein

AbstractPatients with primary sclerosing cholangitis (PSC) constitute 5 to 15% of patients listed for liver transplantation worldwide. Although post-transplant outcomes are favorable, recurrent PSC (rPSC) occurs in an important subset of patients, with higher prevalence rates reported with increasing time from transplant. Given its association with poor graft outcomes and risk of retransplant, effort has been made to understand rPSC, its pathophysiology, and risk factors. This review covers these facets of rPSC and focuses on implicated risk factors including pretransplant recipient characteristics, inflammatory bowel-disease-related factors, and donor-specific and transplant-specific factors. Confirming a diagnosis of rPSC requires thoughtful consideration of alternative etiologies so as to ensure confidence in diagnosis, management, subsequent risk assessment, and counseling for patients. Unfortunately, no cure exists for rPSC; however, future large-scale efforts are underway to better characterize the natural history of rPSC and its associated risk factors with hopes of identifying potential key targets for novel therapies.


2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Laila A. Nahum ◽  
Marina M. Mourão ◽  
Guilherme Oliveira

Schistosomes are digenean blood flukes of aves and mammals comprising 23 species. Some species are causative agents of human schistosomiasis, the second major neglected disease affecting over 230 million people worldwide. Modern technologies including the sequencing and characterization of nucleic acids and proteins have allowed large-scale analyses of parasites and hosts, opening new frontiers in biological research with potential biomedical and biotechnological applications. Nuclear genomes of the three most socioeconomically important species (S. haematobium,S. japonicum, andS. mansoni) have been sequenced and are under intense investigation. Mitochondrial genomes of sixSchistosomaspecies have also been completely sequenced and analysed from an evolutionary perspective. Furthermore, DNA barcoding of mitochondrial sequences is used for biodiversity assessment of schistosomes. Despite the efforts in the characterization ofSchistosomagenomes and transcriptomes, many questions regarding the biology and evolution of this important taxon remain unanswered. This paper aims to discuss some advances in the schistosome research with emphasis on genomics and transcriptomics. It also aims to discuss the main challenges of the current research and to point out some future directions in schistosome studies.


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