Chemical structure, anti-inflammatory and antinociceptive activities of a sulfated polysaccharide from Gracilaria intermedia algae

2020 ◽  
Vol 159 ◽  
pp. 966-975 ◽  
Author(s):  
Luís Eduardo C. Costa ◽  
Tarcisio Vieira Brito ◽  
Renan O. Silva Damasceno ◽  
Willer M. Sousa ◽  
Francisco Clark N. Barros ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Sulfated Polysaccharide ◽  
Anti Inflammatory

Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)

2019 ◽  
Vol 70 (7) ◽  
pp. 2534-2537
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Antonia Poiata ◽  
Mihai Nichifor ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Ethylene Diamine ◽  
Chemical Characteristics ◽  
Gram Negative Bacteria ◽  
Pharmacological Effects ◽  
Physico Chemical ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

Chemical structure and anti-inflammatory activity of a branched polysaccharide isolated from Phellinus baumii

2021 ◽  
pp. 118214
Author(s):  
Yuqing Sun ◽  
Jinxi Huo ◽  
Shi Zhong ◽  
Jianxun Zhu ◽  
Yougui Li ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Inflammatory Activity ◽  
Phellinus Baumii ◽  
Anti Inflammatory

scholarly journals The extracellular matrix of Volvox carteri: molecular structure of the cellular compartment.

1989 ◽  
Vol 109 (6) ◽  
pp. 3493-3501 ◽  
Author(s):  
H Ertl ◽  
R Mengele ◽  
S Wenzl ◽  
J Engel ◽  
M Sumper
Keyword(s):  
Extracellular Matrix ◽  
Chemical Structure ◽  
Chemical Nature ◽  
Sulfated Polysaccharide ◽  
Surface Glycoprotein ◽  
Amino Acid Residues ◽  
Volvox Carteri ◽  
Cellular Compartment ◽  
Cross Links ◽  
Cellular Compartments

The extracellular matrix (ECM) of Volvox contains insoluble fibrous layers that surround individual cells at a distance to form contiguous cellular compartments. Using immunological techniques, we identified a sulfated surface glycoprotein (SSG 185) as the monomeric precursor of this substructure within the ECM. The primary structure of the SSG 185 poly-peptide chain has been derived from cDNA and genomic DNA. A central domain of the protein, 80 amino acid residues long, consists almost exclusively of hydroxyproline residues. The chemical structure of the highly sulfated polysaccharide covalently attached to SSG 185 has been determined by permethylation analysis. As revealed by EM, SSG 185 is a rod-shaped molecule with a 21-nm-long polysaccharide strand protruding from its central region. The chemical nature of the cross-links between SSG 185 monomers is discussed.

Antinociceptive and anti-inflammatory activities of a sulfated polysaccharide isolated from the green seaweed Caulerpa cupressoides

2012 ◽  
Vol 64 (2) ◽  
pp. 282-292 ◽  
Author(s):  
José A.G. Rodrigues ◽  
Edfranck de S.O. Vanderlei ◽  
Luana M.C.M. Silva ◽  
Ianna W.F. de Araújo ◽  
Ismael N.L. de Queiroz ◽  
...  
Keyword(s):  
Sulfated Polysaccharide ◽  
Green Seaweed ◽  
Anti Inflammatory

Substituted galacturonan from starfruit: Chemical structure and antinociceptive and anti-inflammatory effects

2016 ◽  
Vol 84 ◽  
pp. 295-300 ◽  
Author(s):  
Carolina L. Leivas ◽  
Leandro F. Nascimento ◽  
Wellinghton M. Barros ◽  
Adair R.S. Santos ◽  
Marcello Iacomini ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Anti Inflammatory

scholarly journals Inhibitory Effect of Sulfated Polysaccharide from Codium edule P.C. Silva Against 2,4-Dinitrofluorobenzene (DNFB)- Induced Allergic Contact Dermatitis on Female BALB/c Mice

2021 ◽  
Author(s):  
Martin Raemond Brondial Mallabo ◽  
Mary Jho - Anne T. Corpuz ◽  
Reginald B. Salonga ◽  
Ross D. Vasquez
Keyword(s):  
Contact Dermatitis ◽  
Allergic Contact Dermatitis ◽  
Inflammatory Cells ◽  
Sulfated Polysaccharide ◽  
Gel Chromatography ◽  
Dependent Manner ◽  
Tnf Α ◽  
Ifn Γ ◽  
Anti Inflammatory ◽  
Allergic Contact

Purpose: Sulfated polysaccharide (SP) from Codium species has been reported for its anti-inflammatory activities. However, the effect of SP from C. edule on allergic responses has not been studied. The study was conducted to determine the effect of SP (F1) from C. edule on allergic contact dermatitis (ACD) induced by 2,4-dinitrofluorobenzene (DNFB) in female BALB/c mice. Methods: F1 was isolated using DEAE Sepharose Gel Chromatography and chemically identified by LC-MS analyses. The effects of F1 on changes in ear thickness, allergic responses, and histology were evaluated. The effects of F1 on the production of inflammatory cytokines IFN- γ and TNF-α in serum were also quantified and compared with standard prednisolone therapy. Results: F1 was identified as a heteropolysaccharide with β-D-galactans and β-L-arabinans units. F1 was non-toxic at 2000 mg/kg. Administration of F1 in DNFB-challenged mice significantly suppressed the increase in ear thickness, erythema, desquamation, and proliferation of inflammatory cells. F1 significantly decreased the production of inflammatory markers, IFN- γ and TNF-α in a dose-dependent manner when compared to the untreated group (p<0.05). Conclusion: Results suggest that F1 from C. edule is a bioactive sulfated heteropolysaccharide with anti-inflammatory activity and might be a valuable candidate molecule for the treatment of allergic diseases such as ACD.

scholarly journals Design, Synthesis and Characterization of Some Novel benzamide derivatives and it's Pharmacological Screening

2020 ◽  
pp. 68-74 ◽  
Author(s):  
Akshay R. Yadav ◽  
Shrinivas K. Mohite
Keyword(s):  
Chemical Structure ◽  
Design Synthesis ◽  
Different Types ◽  
Anti Inflammatory ◽  
Benzoyl Isothiocyanate ◽  
Pharmacological Screening ◽  
Benzamide Derivatives

The new series of substituted N-(phenylcarbamothioyl)benzamide derivatives (2a-2f) was designed, development and synthesized by using conventional and microwave method. In present work 6 different N-(phenylcarbamothioyl)benzamide were synthesized. Substituted benzoyl chloride is converted into benzoyl isothiocyanate by esterification. Benzoyl isothiocyanate is converted into Substituted (phenylcarbamothioyl)benzamide by treating with different types of substituted aniline. Confirmation of the chemical structure of the synthesized was substantiated by TLC, IR, 1H NMR, MS spectroscopy.Novel synthesized compounds screened for their in vivo and in-vitro anti-inflammatory studies and compound 2f shows promising anti-inflammatory activity.

scholarly journals Eccentric Connectivity Index of t-Polyacenic Nanotubes

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Jia-Bao Liu ◽  
Hani Shaker ◽  
Imran Nadeem ◽  
Mohammad Reza Farahani
Keyword(s):  
Chemical Compound ◽  
Chemical Structure ◽  
Biological Activities ◽  
Connectivity Index ◽  
Infinite Class ◽  
Eccentric Connectivity Index ◽  
Anti Inflammatory ◽  
High Degree ◽  
Structure Descriptor

The eccentric connectivity index ECI is a chemical structure descriptor that is currently being used for the modeling of biological activities of a chemical compound. This index has been proved to provide a high degree of predictability as compared to some other well-known indices in case of anticonvulsant, anti-inflammatory, and diuretic activities. The ECI of an infinite class of 1-polyacenic (phenylenic) nanotubes has been recently studied. In this article, we extend this study to generalized polyacenic nanotubes and find ECI of t-polyacenic nanotubes for t>1.

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