Study of Physico-chemical Characteristics and Pharmacological Effects of 1-Ethyl-Salicyldene-bis-Ethylene-Diamine and Its Complex with Mn(II)

2019 ◽  
Vol 70 (7) ◽  
pp. 2534-2537
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Antonia Poiata ◽  
Mihai Nichifor ◽  
Nela Bibire ◽  
...  
Keyword(s):  
Schiff Base ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Ethylene Diamine ◽  
Chemical Characteristics ◽  
Gram Negative Bacteria ◽  
Pharmacological Effects ◽  
Physico Chemical ◽  
Anti Inflammatory ◽  
Inflammatory Effect

The paper presents the synthesis of a new complex combination of a Bis-Schiff base with Mn(II) ions with great potential for antimicrobial and anti-inflammatory activity. A new complex of the Salen-type ligand, 1-ethyl-salicylidene-bis-ethylene diamine was synthetized using Mn(II) ions. The chemical structure was confirmed through 1H-NMR and IR spectroscopy. The antimicrobial activities of the Bis-Schiff base and its complex were tested in comparison with Ampicillin, Chloramphenicol, Tetracycline, Ofloxacin and Nystatin. Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

scholarly journals The Influence of the Structure of Several New ortho-Hydroxy-Ketone Derived bis-Schiff Bases on Their Antibacterial and Anti-Inflammatory Activity

2020 ◽  
Vol 71 (1) ◽  
pp. 244-248
Author(s):  
Gladiola Tantaru ◽  
Mihai Apostu ◽  
Cristina Mihaela Ghiciuc ◽  
Antonia Poiata ◽  
Alina Stefanache ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Schiff Bases ◽  
Antimicrobial Activities ◽  
Hydroxy Ketone ◽  
Gram Negative Bacteria ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Inflammatory Effect

The article presents some bis-Schiff bases - halogenated derivatives of ortho-hydroxy-ketones - with great potential for antimicrobial and antiinflammatory activity. The antimicrobial activities of the Schiff bases were tested in comparison with Chloramphenicol, Nystatin, and Ampicillin upon the following strains: Staphylococcus aureus (ATCC 25923), Sarcina lutea (ATCC 9341), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans (ATCC 1023), Candida glabrata, two Staphylococcus aureus strains, and several clinical isolates (Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae). Those compounds were found to be active against Gram-positive or Gram-negative bacteria, and had an anti-inflammatory effect comparable to that of Indomethacin.

Assessment of Cota altissima (L.) J. Gay for phytochemical composition and antioxidant, anti-inflammatory, antidiabetic and antimicrobial activities

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Gamze Göger ◽  
Muhammed Allak ◽  
Ali Şen ◽  
Fatih Göger ◽  
Mehmet Tekin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Essential Oil ◽  
Antioxidant Activities ◽  
Antimicrobial Activities ◽  
Antidiabetic Activity ◽  
Gram Negative Bacteria ◽  
Inhibitory Effects ◽  
Dicaffeoylquinic Acid ◽  
Anti Inflammatory ◽  
Phytochemical Profiles

Abstract Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissima L. J. Gay (syn. Anthemis altissima L.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAM showed the highest antioxidant activity against DPPH and ABTS radicals with IC50 values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAE demonstrated the highest antilipoxygenase activity with an IC50 value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50 value of 396.40 μg/mL in the antidiabetic activity. CAH was effective against Staphylococcus aureus at MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.

Acute toxicity, anti-inflammatory, analgesic and antipyretic effects of aqueous and hydroethanolic extracts of Brenania brieyi (Rubiaceae)

2021 ◽  
Vol 3 (1) ◽  
pp. 019-032
Author(s):  
Nkundineza JC ◽  
Nsonde Ntandou GF ◽  
Boumba LS ◽  
Kibamgou S ◽  
Motondo E ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Acute Toxicity ◽  
Aqueous Extract ◽  
Ethanolic Extract ◽  
Tail Flick ◽  
Pharmacological Effects ◽  
Tail Flick Test ◽  
Ethanolic Extracts ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Brenania brieyi (Rubiaceae) is widely used in traditional Congolese medicine in the treatment of many pathologies that are manifested by inflammation, pain and fever. The objective of this study was to study the acute toxicity as well as to evaluate the antipyretic, analgesic and anti-inflammatory effects of the aqueous and hydro-ethanolic extracts of Brenania brieyibark on models of pyrexia, algesia and inflammation induced in rodents. The aqueous extract of Brenania brieyidoes not cause any mortality up to the dose of 4000 mg/kg, but promotes a slight increase in body weight. From 2000 mg/kg, the signs of toxicity observed were the significant decrease in mobility as well as the loss of alertness. At doses of 100 and 200 mg/kg, aqueous and hydro-ethanolic Brenania brieyiextracts showed a very significant anti-inflammatory effect (***p< 0.001) on edemas induced by carrageenin (1%), formaldehyde (2.5%) and histamine (1 mg/mL), greater than that of diclofenac at 10 mg/kg. At 200 mg/kg, both extracts showed a very significant analgesic effect (***p< 0.001), greater than that of paracetamol 100 mg/kg against pain induced by acetic acid 0.6% and formaldehyde 2.5%. Brenania brieyiwas slightly effective in the tail flick test. Brewer's yeast-induced hyperthermia was reduced by both extracts. However, the hydro-ethanolic extract proves to be more effective than the aqueous extract in all the tests carried out. These pharmacological effects would be related to the presence of alkaloids, tannins, flavonoids, anthraquinones, oses and saponosides.

Chemical structure and anti-inflammatory effect of polysaccharide extracted from Morinda citrifolia Linn (Noni)

2018 ◽  
Vol 197 ◽  
pp. 515-523 ◽  
Author(s):  
Stefany Guimarães Sousa ◽  
Lorena Almeida Oliveira ◽  
Diva de Aguiar Magalhães ◽  
Tarcisio Vieira de Brito ◽  
Jalles Arruda Batista ◽  
...  
Keyword(s):  
Chemical Structure ◽  
Morinda Citrifolia ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Chemical Composition and Pharmacological Effects of Geopropolis Produced byMelipona quadrifasciata anthidioides

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Cintia Miranda dos Santos ◽  
Jaqueline Ferreira Campos ◽  
Helder Freitas dos Santos ◽  
José Benedito Perrella Balestieri ◽  
Denise Brentan Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chemical Composition ◽  
Antimicrobial Activities ◽  
Pharmacological Effects ◽  
Antimicrobial Drug Resistance ◽  
Gram Positive Bacteria ◽  
Microbial Infections ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Hydroethanolic Extract

Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis ofMelipona quadrifasciata anthidioidesand to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies ofS. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential ofM. q. anthidioidesgeopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.

Curcumin-Loaded Nanocapsules: Formulation and Influence of the Nanoencapsulation Processes Variables on the Physico-Chemical Characteristics of the Particles

2009 ◽  
Vol 7 (1) ◽  
Author(s):  
Fabien Salaün ◽  
Isabelle Vroman
Keyword(s):  
Chemical Structure ◽  
Encapsulation Efficiency ◽  
Chemical Characteristics ◽  
Loading Capacity ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Encapsulation Process ◽  
The Mean ◽  
Formulation Parameters ◽  
Polymer Wall

The aim of this work was to assess the influence of various formulation parameters on the incorporation of Curcumin into nanoparticles. For this purpose, the influence of the aqueous monomer (ethylene diamine, hexamethylene diamine, and 1,4-diaminobutane), as well as the effect of the stirring rate and the influence of the nanoencapsulation method on the encapsulation efficiency were investigated. It was found that variation in the amount of ingredients had profound effects on the curcuminoid loading capacity, the mean particle size, and size distribution. Furthermore, from the thermal results, it is concluded that the reactivity of diamine and the length of flexible methylene chain in diamine determine the thermal properties of resultant polymer wall membrane. The encapsulation yield depends not only on the encapsulation process but also on the chemical structure of the diamine. Whereas, the size and its distribution vary according to the process choice and the emulsification stirring rate.

scholarly journals Caftaric acid: an overview on its structure, daily consumption, bioavailability and pharmacological effects

2020 ◽  
Vol 10 (3) ◽  
pp. 5616-5623 ◽  
Keyword(s):  
Total Concentration ◽  
Grape Juice ◽  
Major Constituent ◽  
Total Phenolic ◽  
Pharmacological Effects ◽  
Daily Consumption ◽  
High Blood Glucose ◽  
Caftaric Acid ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Caftaric acid is simply known as phenolic derivative and it is present in high concentrations in grape seeds and juice. The chemical structure of caftaric acid is C13H12O9, with molar mass of the acid equal to 312.230 g/mol. Caftaric acid is formed united of caffeic acid and tartaric acid. This paper reviews caftaric acid structure, daily consumption, bioavailability and pharmacological effects. The caftaric acid quickly passes to the stomach and duodenum and increases the absorption of the acid in the intestinal Caco-2 cells. The antioxidant effect of grape stem was related to its caftaric acid constituent. The grape juice has anti-inflammatory effect and this anti-inflammatory effect is correlated with the main constituent of this juice which is caftaric acid. Caftaric acid has antimutagenic effect in an animal model suggesting that caftaric acid participates in chemopreventive effect of the Yamabudo juice. The "liver detoxifying" effect is observed and correlated with oral supplementation with aqueous decoctions of Cichorium spinosum and Cichorium intybus in Greece where caftaric acid is the major constituent of these two aqueous decoctions. The caftaric acid possesses a double effect through decreasing high blood glucose and high blood pressure so this acid can be used in the treatment of diabetes and hypertension. The caftaric acid increases granulocyte/macrophage-colony forming cells from femurs of female animals' models by 70%. In conclusion, caftaric acid is presented about 5 mg/100 cm3 grape juice. The acid is quickly passes into the stomach and duodenum. The trans-caftaric acid represents 85% of the total phenolic content in the Concord grape juice with a total concentration of 444 μmol/L. The caftaric acid has many pharmacological effects such as antioxidant, anti-inflammatory, antimutagenic and anticarcinogenic, hepatoprotective, anti-diabetic and anti-hypertensive, anti-obesity and anti-metabolic syndrome and neuroprotective effects.

scholarly journals The medical importance of Iris pallida – A review

2021 ◽  
Vol 1 (2) ◽  
pp. 190-196
Author(s):  
Ali Esmail Al-Snafi
Keyword(s):  
Chemical Constituents ◽  
Antimicrobial Activities ◽  
Pharmacological Effects ◽  
Current Review ◽  
Medical Importance ◽  
Anti Inflammatory

Iris pallid (Family: Iridaceae) was used traditionally asantispasmodic, aperient, aromatic, attenuant, carminative, detoxicant, diuretic, emetic, emmenagogue, expectorant, fixative, laxative, pectoral, purgative and sedative. It contained oils and aromatic constituents, fat, resin, a large quantity of starch, mucilage, phenolics, flavonoids and glucosides. Iris pallida possessed many pharmacological effects included anti-inflammatory, antioxidant, anti-aging, anticancer, antiparasitic and antimicrobial activities. The current review will highlight the chemical constituents and pharmacological effects of Iris pallida.

scholarly journals Progressive Applications of Hyperbranched Polymer Based on Diarylamine: Antimicrobial, Anti-Biofilm and Anti-Aerobic Corrosion

Materials ◽  
2020 ◽  
Vol 13 (9) ◽  
pp. 2076
Author(s):  
Khalid I. Kabel ◽  
Ahmed Labena ◽  
Mohamed Keshawy ◽  
Wael N. Hozzein
Keyword(s):  
Corrosion Inhibition ◽  
Methyl Acrylate ◽  
Chemical Structure ◽  
Antimicrobial Activities ◽  
Metal Corrosion ◽  
Gram Negative Bacteria ◽  
One Pot ◽  
Yeast Strains ◽  
1Hnmr Spectroscopy ◽  
Positive Controls

New generations of hyperbranched aramids were synthesized from diarylamine and methyl acrylate using an AB2 monomer approach in a straightforward one-pot preparation. The chemical structure of hyperbranched Phenylenediamine/Methyl Acrylate HB(PDMA was confirmed by Fourier Transform Infrared (FTIR) and Nuclear Magnetic Resonance (1HNMR) spectroscopy. In addition, the particle’s size and distribution were recorded using Dynamic Light Scattering (DLS). Moreover, the synthesized HB(PDMA)s displayed broad-spectrum antimicrobial activities against Gram-positive and Gram-negative bacteria as well as yeast strains and anti-biofilm activity where the highest activity was attributed to HB(PDMA)G4 at the lowest Minimum Inhibitory, Minimum Bactericidal, and Fungicidal Concentrations (MIC, MBC, and MFC, respectively). Furthermore, the HB(PDMA)s expressed anti-bacterial activity against isolated Pseudomonas sp. (R301) at a salinity of 35,000 ppm (NaCl). In addition, they revealed different corrosion inhibition efficiencies at the cultivated medium salinity at the estimated minimum bactericidal concentrations. The highest metal corrosion inhibition efficiencies were 59.5 and 94.3% for HB(PDMA)G4 at the Minimum Bactericidal Concentrations (MBCs) and two times Minimum Bactericidal Concentrations (2XMBCs), respectively, in comparison to both negative and positive controls.

Natural Fused Heterocyclic Flavonoids: Potent Candidates As Anti-Inflammatory And Anti-Allergic Agents In The Treatment Of Asthma

2019 ◽  
Vol 15 ◽  
Author(s):  
Rajwinder Kaur ◽  
Kirandeep Kaur ◽  
Rashmi Arora ◽  
Balraj Saini ◽  
Sandeep Arora
Keyword(s):  
Clinical Trials ◽  
Mast Cells ◽  
Human Neutrophil ◽  
Chemical Structure ◽  
Polyphenolic Compounds ◽  
The Other ◽  
Human Neutrophil Elastase ◽  
Pharmacological Effects ◽  
Anti Cancer ◽  
Anti Inflammatory

: In the last two decades, the flavanoids containing fused heterocyclic nucleus in their chemical structure have emerged to display a variety of pharmacological effects including anti-allergic and anti-inflammatory the most recent to the list. These polyphenolic compounds exert their pharmacological effect by various mechanisms including inhibition of human neutrophil elastase, cytokines (Interleukins- IL-3 and IL-4) and mast cells. Quercetin, Pycnogenol, Rutin and Kampferol are the few bio-flavonols out of hundreds of other compounds still under clinical trials that have been studied most. These flavonoids have been also reported to the other pharmacological effects like anti-cancer, anti-oxidants, anti-hypertensive, anti-viral, anti-ulcerogenic, anti-platelet, anti-hypotensive and anti-hepatotoxic. With all these versatile properties heterocyclic containing flavonoids may be a powerful candidate for the discovery of their utilization in other ailments like asthma.

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