scholarly journals Parameters of metabolic syndrome are markers of coronary heart disease – An observational study

2010 ◽  
Vol 2 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Faria Afsana ◽  
Zafar Ahmed Latif ◽  
M. Maksumul Haq
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Observational Study

Abstract P050: Glycated Hemoglobin Versus Fasting Glucose in Defining Metabolic Syndrome and Prediction of Coronary Heart Disease

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Julie K Bower ◽  
Vijay Nambi ◽  
Mariana Lazo ◽  
Andreea Rawlings ◽  
Meredith C Foster ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Cox Proportional Hazards ◽  
Diabetes Diagnosis ◽  
The Metabolic Syndrome ◽  
C Statistic ◽  
Definition Of

Introduction. Fasting glucose (FG) is part of the Adult Treatment Panel III (ATP III) criteria for defining the metabolic syndrome (MetS). Glycated hemoglobin (HbA1c) is a measure of 2-3 month endogenous glucose exposure and is now recommended for diabetes diagnosis and screening for high-risk individuals. The aim of this study was to evaluate if replacing FG with HbA1c to define MetS improves prediction of incident coronary heart disease (CHD) in the Atherosclerosis Risk in Communities (ARIC) cohort. Methods. We included 11,194 ARIC participants without diabetes (based on diagnosis, medication use, FG ≥126 mg/dL, or HbA1c ≥6.5%) or prevalent CHD at baseline (1990-92). Cox proportional hazards models (adjusted for age, race, and study center) were used to compare the association between MetS defined using HbA1c (5.7-6.4%) or FG (100-125 mg/dL, based on ATP III guidelines) and risk of CHD (defined by myocardial infarction or fatal CHD, event data available through 2009). Results. Study participants had a mean age at baseline of 57 years, 43% were male, and 79% were white; median follow-up time was 16 years. Thirty-four percent of the study population had both normal FG (<100 mg/dL) and HbA1c (<5.7%), 37% had elevated FG and normal HbA1c, 4% had normal FG and elevated HbA1c, and 25% had both elevated FG (100-125 mg/dL) and HbA1c (5.7-6.4%). The association of combined FG and HbA1c categories with incident CHD are shown in the Figure. The adjusted hazard ratio predicting for incident CHD from MetS status was 1.43 (95% CI: 1.25-1.63, c-statistic: 0.61) using FG in the definition of MetS and 1.69 (95% CI: 1.48-1.93, c-statistic: 0.62) in the model replacing FG with HbA1c. Conclusions. Incorporating HbA1c into the definition of the MetS may help in identifying individuals who should be targeted for aggressive CHD risk factor reduction. Additionally, HbA1c may be useful clinically and in research settings for identifying individuals with MetS in cases where FG measures are not available.

Impact of Cardiac Rehabilitation on Metabolic Syndrome in Iranian Patients with Coronary Heart Disease: The Role of Obesity

2012 ◽  
Vol 37 (2) ◽  
pp. 66-73 ◽  
Author(s):  
Ali Kabir ◽  
Nizal Sarrafzadegan ◽  
Afshin Amini ◽  
Reza Safi Aryan ◽  
Fahimeh Habibi Kerahroodi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiac Rehabilitation ◽  
Iranian Patients

Possibilities of Multislice Computed Tomography in the Diagnosis of Atheroclerotic Lesions of the Main Vessels for Type 2 Diabetes and Other Variants Disorders of Carbohydrate Metabolism

2021 ◽  
Vol 65 (5) ◽  
pp. 45-50
Author(s):  
E Praskurnichiy ◽  
E Ionova ◽  
I Begunova ◽  
A Knyazev
Keyword(s):  
Computed Tomography ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Carbohydrate Metabolism ◽  
Multislice Computed Tomography ◽  
Early Stage ◽  
Laboratory Diagnostics

Purpose: Study of structural and morphological features of atherosclerotic lesions of large main vessels (carotid arteries) in type 2 diabetes mellitus. Material and methods: The study included 78 patients. Exclusion criteria: age under 40 years, pregnancy, acute infectious diseases, as well as chronic diseases within less than 2 weeks from the onset of complete clinical and laboratory remission, severe cardiac (LVEF < 30 %) and renal (blood creatinine > 300 mmol/l) insufficiency, alcohol abuse or drug dependence. There were 44 men (56.4 %) and 34 women (43.6 %) in the group surveyed. Coronary heart disease was detected in 54 (69.2 %) individuals, 24 (30.8 %) of the examined individuals had no signs of coronary heart disease; 19 (24.4 %) people had a history of stroke, 18 (23 %) people — myocardial infarction. 42 people (53.8 %) had dyscirculatory encephalopathy of various degrees, 34 (43.6 %) had hypertension, 42 patients had carbohydrate metabolism disorders, 12 (15.3 %) patients had type 2 diabetes, and 30 (38.4 %) patients had metabolic syndrome. Three groups of subjects were formed. The group of people without metabolic syndrome included 48 people (61.5 % of the total number of examined). The group of people with metabolic syndrome without type 2 diabetes included 18 individuals (23.1 % of the total number of examined). The group of people with type 2 diabetes included 12 individuals (15.4 % of the total number of examined). The examination of patients included: physical examination; laboratory diagnostics; electrocardiography; transthoracic echocardiography; multislice computed tomography with angiocontrast. Results: 78 patients were found to have different density of atherosclerotic plaques. There were no differences in volume among the groups of people surveyed. In patients with type 2 diabetes, there is a decrease in the lipid-fibrous component and an increase in the density of atherosclerotic plaque. Conclusion: Multislice computed tomography can detect various forms of vascular damage, the progression of the process, and assess the severity of structural and morphological manifestations of atherosclerosis in type 2 diabetes and metabolic syndrome at an early stage.

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