Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment

There has been, and continues to be, significant controversy over the definition of an “optimal” surgical margin in breast-conserving therapy (BCT). The historic basis of this controversy stems from the original trials documenting the safety of BCT and many conflicting retrospective studies that have sought to define the association between surgical margin width and outcomes over the last 20 years. It is important to understand that margin assessment is an inexact science, and current laboratory approaches to surgical-margin assessment represent only a sampling of the surgical margin. Currently available evidence suggests that decisions regarding surgical margins in BCT should be made in the context of what is known about the biology of breast cancer, as well the interactions of tumor biology, adjuvant treatment for breast cancer, and outcomes. Achieving consensus on management of surgical margins in BCT should be a clinical priority as it offers the opportunity to reduce the burden of breast cancer treatment on patients without compromising cancer-related outcomes.

Download Full-text

Electrical impedance acquisition system for surgical margin assessment during robot-assisted laparoscopic prostatectomy

10.1349/ddlp.2218 ◽

2016 ◽

Author(s):

Shadab Khan

Keyword(s):

Electrical Impedance ◽

Surgical Margin ◽

Acquisition System ◽

Margin Assessment ◽

Robot Assisted ◽

Laparoscopic Prostatectomy

Download Full-text

Towards intraoperative surgical margin assessment and visualization using bioimpedance properties of the tissue

10.1117/12.2082920 ◽

2015 ◽

Cited By ~ 2

Author(s):

Shadab Khan ◽

Aditya Mahara ◽

Elias S. Hyams ◽

Alan Schned ◽

Ryan Halter

Keyword(s):

Surgical Margin ◽

Margin Assessment

Download Full-text

Feasibility of multimodal multiphoton microscopy to facilitate surgical margin assessment in pancreatic cancer

Applied Optics ◽

10.1364/ao.391315 ◽

2020 ◽

Vol 59 (22) ◽

pp. G1

Author(s):

Thu Pham ◽

Bhaskar Banerjee ◽

Benjamin Cromey ◽

Soroush Mehravar ◽

Bethany Skovan ◽

...

Keyword(s):

Pancreatic Cancer ◽

Multiphoton Microscopy ◽

Surgical Margin ◽

Margin Assessment

Download Full-text

Postoperative radiotherapy of cervival carcinoma: Treatment results and analysis of prognostic factors

Acta chirurgica iugoslavica ◽

10.2298/aci0904195p ◽

2009 ◽

Vol 56 (4) ◽

pp. 195-200

Author(s):

V. Plesinac-Karapandzic ◽

N. Borojevic ◽

Z. Milosevic ◽

B. Markovic ◽

M. Nikitovic ◽

...

Keyword(s):

Cervical Cancer ◽

Prognostic Factors ◽

Lymph Nodes ◽

Cancer Patients ◽

Early Stage ◽

Postoperative Radiotherapy ◽

Surgical Margin ◽

Disease Free Survival ◽

Residual Tumor ◽

Positive Surgical Margin

The purpose of the study was to evaluate the efficacy of postoperative radiotherapy (RT) and to investigate prognostic factors for early-stage cervical cancer patients. We reviewed the medical records of 162 cervical cancer patients treated by RT during 2003 year. RT included 30- 45Gy of external photons to pelvis in 12-25 fractions. Brachytherapy with 192Ir was delivered in 3-5 fractions to a dose of 27-32 Gy. The mean age was 49 years (range 27-71). Majority of patients 130 had Stage Ib. Radical hysterectomy with lymphadenectomy was performed in 122pts. and simple hysterectomy in 40 pts. The 5-year actuarial overall survival (OS) for all patients was 92,6% and disease-free survival (DFS) was 90,9%.There was statistically significant differences in OS and DFS in pat. with positive vs. negative pelvic lymph nodes; tumor 4cm vs. tumor <4cm; positive vs. negative surgical margin/residual tumor (p<0,05). Late GIT complications were determined in 35,8% and UT in 12,3%. In conclusion, postoperative radiotherapy has achieved high-satisfactory survival with acceptable complications. The survival benefit was less evident among patients with positive lymph nodes, tumor > 4cm and positive surgical margin/ residual tumor.

Download Full-text