Cytotoxic potential of Artemisia absinthium extract loaded polymeric nanoparticles against breast cancer cells: Insight into the protein targets

2020 ◽  
Vol 586 ◽  
pp. 119583 ◽  
Author(s):  
Mohd Mughees ◽  
Saima Wajid ◽  
Mohd Samim
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Polymeric Nanoparticles ◽  
Cytotoxic Potential ◽  
Artemisia Absinthium ◽  
Protein Targets ◽  
Insight Into

scholarly journals Anticancer Potential of Silibinin Loaded Polymeric Nanoparticles against Breast Cancer Cells: Insight into the Apoptotic Genes Targets

2021 ◽  
Vol 22 (8) ◽  
pp. 2587-2596
Author(s):  
Ali Pourgholi ◽  
Mehdi Dadashpour ◽  
Akram Mousapour ◽  
Akram Firouzi Amandi ◽  
Nosratollah Zarghami
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Polymeric Nanoparticles ◽  
Apoptotic Genes ◽  
Insight Into

Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells

2019 ◽  
Vol 7 (39) ◽  
pp. 6048-6063 ◽  
Author(s):  
Mohd Mughees ◽  
Mohd Samim ◽  
Yadhu Sharma ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Cytotoxic Action ◽  
Protein Targets ◽  
Targeted Drug

The shortcomings of the currently available anti-breast cancer agents compel the development of the safer targeted drug delivery for the treatment of breast cancer.

scholarly journals Induction of Estrogen Receptor β-mediated Autophagy Sensitizes Breast Cancer Cells to TAD1822-7, a Novel Biphenyl Urea Taspine Derivative

2021 ◽  
Author(s):  
Qi Su ◽  
Qing Wu ◽  
Kun Chen ◽  
Jingjing Wang ◽  
Ammar Sarwar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Annexin V ◽  
Female Breast Cancer ◽  
Estrogen Receptor Β ◽  
Inhibitory Effects ◽  
Insight Into

Abstract Female breast cancer has become the most commonly diagnosed cancer worldwide. As a tumor suppressor, estrogen receptor β (ERβ) is a potential target for breast cancer therapy. TAD1822-7 was evaluated for ERβ-mediated autophagy and cell death using cell proliferation assay, Annexin V/PI staining, immunofluorescence, western blotting and hypoxia cell models. TAD1822-7 upregulated ERβ causing cell death and induced mitochondrial dysfunction and autophagy companied with mitochondrial located ERβ. Enhanced levels of LC3-II and p62 indicated that TAD1822-7 blocked the late-stage autolysosome formation, leading to cell death. Mechanistically, TAD1822-7-induced cell death was mediated by PI3K/AKT signaling pathways. Moreover, TAD1822-7 modulated HIF functions and autophagy via the inhibition of HIF-1β in the context of hypoxia-induced autophagy. TAD1822-7 inhibited hypoxia-inducted autophagy and PI3K/AKT pathway. These findings provide new insight into the mechanism underlying the inhibitory effects of TAD1822-7 via ERβ-mediated pathways in breast cancer cells.

scholarly journals Analysis of the essential oil from Lantana camara leaves and its cytotoxic potential against T-47D breast cancer cells

2021 ◽  
Vol 12 (1) ◽  
pp. 1-9
Author(s):  
Suryati Suryati ◽  
Enda Desriansyah Aziz ◽  
Mai Efdi ◽  
Fatma Sri Wahyuni ◽  
Dira Hefni
Keyword(s):  
Breast Cancer ◽  
Mass Spectrometry ◽  
Essential Oil ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Artemia Salina ◽  
Lantana Camara ◽  
Gas Chromatography Mass Spectrometry ◽  
Cytotoxic Potential ◽  
Main Compound

Lantana camara Linn is a family of Verbenaceae which grows wild and is widespread in various both tropical and sub-tropical countries. Isolation essential oil of the L. camara leaves extracted by hydrodistillation and were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS). The results of GC-MS analysis show isocaryophyllene (14.39%), ρ-cymene (8.17 %), β-cubebene (7.8 %), α-pinene (7.64 %), and β-elemene (5.51 %) as the main compound. The cytotoxic activity of the isolated essential oil was highly toxic both to Artemia salina shrimp larvae (LC50 15.92 µg/mL) and to breast cancer cells T-47D (IC50 10.67 µM).

scholarly journals Correction: Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells

2019 ◽  
Vol 7 (43) ◽  
pp. 6868-6868
Author(s):  
Mohd Mughees ◽  
Mohd Samim ◽  
Yadhu Sharma ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Action ◽  
Protein Targets

Correction for ‘Identification of protein targets and the mechanism of the cytotoxic action of Ipomoea turpethum extract loaded nanoparticles against breast cancer cells’ by Mohd Mughees et al., J. Mater. Chem. B, 2019, 7, 6048–6063.

scholarly journals PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation

2019 ◽  
Vol 30 (18) ◽  
pp. 2367-2376 ◽  
Author(s):  
Zahra Erami ◽  
Samantha Heitz ◽  
Anne R. Bresnick ◽  
Jonathan M. Backer
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Tyrosine Kinases ◽  
Breast Cancer Cells ◽  
Matrix Metalloproteases ◽  
Ph Domain ◽  
Integrin Activation ◽  
G Protein Coupled ◽  
Insight Into

The invasion of tumor cells from the primary tumor is mediated by invadopodia, actin-rich protrusive organelles that secrete matrix metalloproteases and degrade the extracellular matrix. This coupling between protrusive activity and matrix degradation facilitates tumor invasion. We previously reported that the PI3Kβ isoform of PI 3-kinase, which is regulated by both receptor tyrosine kinases and G protein–coupled receptors, is required for invasion and gelatin degradation in breast cancer cells. We have now defined the mechanism by which PI3Kβ regulates invadopodia. We find that PI3Kβ is specifically activated downstream from integrins, and is required for integrin-stimulated spreading and haptotaxis as well as integrin-stimulated invadopodia formation. Surprisingly, these integrin-stimulated and PI3Kβ-dependent responses require the production of PI(3,4)P2 by the phosphoinositide 5′-phosphatase SHIP2. Thus, integrin activation of PI3Kβ is coupled to the SHIP2-dependent production of PI(3,4)P2, which regulates the recruitment of PH domain-containing scaffolds such as lamellipodin to invadopodia. These findings provide novel mechanistic insight into the role of PI3Kβ in the regulation of invadopodia in breast cancer cells.

Synthesis and characterisation of arsenic nanoparticles and its interaction with DNA and cytotoxic potential on breast cancer cells

2018 ◽  
Vol 295 ◽  
pp. 73-83 ◽  
Author(s):  
Ariraman Subastri ◽  
Viswanathan Arun ◽  
Preeti Sharma ◽  
Ezhuthupurakkal Preedia babu ◽  
Arumugam Suyavaran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cytotoxic Potential

scholarly journals Electrospray-based synthesis of fluorescent poly(d,l-lactide-co-glycolide) nanoparticles for the efficient delivery of an anticancer drug and self-monitoring its effect in drug-resistant breast cancer cells

2020 ◽  
Vol 1 (8) ◽  
pp. 3033-3048
Author(s):  
Manosree Chatterjee ◽  
Ritwik Maity ◽  
Souvik Das ◽  
Nibedita Mahata ◽  
Biswarup Basu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Polymeric Nanoparticles ◽  
Metastatic Breast ◽  
Drug Resistant ◽  
Blue Fluorescence ◽  
Self Monitoring ◽  
Novel Approach ◽  
Efficient Delivery

A novel approach used to synthesize antimetabolite-conjugated and intense blue fluorescence-emitting smart polymeric nanoparticles is reported for the efficient delivery of anticancer drugs and self-monitoring their effect in drug-resistant metastatic breast cancer cells.

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