Lipid-microparticles for pulmonary delivery of active pharmaceutical ingredients: impact of lipid crystallization on spray-drying processability

Flash Nanoprecipitation ◽

Size Controlled

A flow-based flash nanoprecipitation of size-controlled d-leucine nanoparticles as glidants for pulmonary delivery of active pharmaceutical ingredients.

Spray Drying Tailored Mannitol Carrier Particles for Dry Powder Inhalation with Differently Shaped Active Pharmaceutical Ingredients

Process-Spray ◽

10.1007/978-3-319-32370-1_14 ◽

2016 ◽

pp. 517-566 ◽

Cited By ~ 1

Author(s):

Mathias Mönckedieck ◽

Jens Kamplade ◽

Eva Maria Littringer ◽

Axel Mescher ◽

Srikanth Gopireddy ◽

...

Keyword(s):

Spray Drying ◽

Dry Powder Inhalation ◽

Dry Powder ◽

Pharmaceutical Ingredients

In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

10.26434/chemrxiv.8074508 ◽

2019 ◽

Author(s):

Bruno Cerra ◽

Mosca Gabriele ◽

Maurizio Ricci ◽

Aurelie Schoubben ◽

Antimo Gioiello

Keyword(s):

Spray Drying ◽

Marked Improvement ◽

Sem Analysis ◽

Flash Nanoprecipitation ◽

Aerodynamic Properties ◽

Economic Method ◽

Physical Mixing ◽

Size Controlled

<p>In this work we report the development of a cheap and scalable flow-based flash nanoprecipitation approach to prepare D-leucine nanoparticles particularly useful as glidants in dry powder for inhalation. Starting from preliminary batch screens, the process was successfully optimized and scaled-up under mesofluidic conditions. The nebulization with both mini and nano spray-dryer, the SEM analysis of nanoparticles and the aerodynamic evaluation of a formulation obtained by physical mixing of atomized D-leucine powders with budenoside showed an excellent decrease in particle size without altering the morphology, and a marked improvement in the aerodynamic properties of the drug. This simple and economic method by physical mixing of leucine with micronized active pharmaceutical ingredients can represent a valid alternative to co-spray-drying.</p>

A REVIEW ON MOUTH DISSOLVING TABLETS

INDIAN DRUGS ◽

10.53879/id.50.11.p0005 ◽

2013 ◽

Vol 50 (11) ◽

pp. 5-14

Author(s):

S. Rathod ◽

◽

M. Phansekar ◽

A. Bhagwan ◽

G. Surve

Keyword(s):

Pharmaceutical Industry ◽

Oral Cavity ◽

Spray Drying ◽

Moisture Treatment ◽

Additional Water ◽

Fast Dissolution ◽

Increasing Demand

Mouth Dissolving Tablets (MDTs) have received ever-increasing demand during the last decade and the field has become a rapidly growing area of research in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several MDT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail MDT technologies based on lyophilization, moulding, sublimation and compaction, as well as approaches to enhance the MDT properties, such as spray drying, moisture treatment, sintering, and use of sugar-based disintegrants.

Engineering Active Pharmaceutical Ingredients by Spray Drying: Effects on Physical Properties and In Vitro Dissolution

Drying Technology ◽

10.1080/07373937.2012.679348 ◽

2012 ◽

Vol 30 (9) ◽

pp. 905-913 ◽

Cited By ~ 11

Author(s):

R. M. Martins ◽

M. O. Machado ◽

S. V. Pereira ◽

A. B. F. L. Nosari ◽

L. A. Tacon ◽

...

Keyword(s):

Physical Properties ◽

Spray Drying ◽

In Vitro Dissolution ◽

Pharmaceutical Ingredients

Nano Spray Drying as an Innovative Technology for Encapsulating Hydrophilic Active Pharmaceutical Ingredients (API)

Journal of Nanomedicine & Nanotechnology ◽

10.4172/2157-7439.1000186 ◽

2013 ◽

Vol 4 (6) ◽

Cited By ~ 22

Author(s):

Adriano M Oliveira ◽

Kleber L Guimaraes ◽

Natalia NP Cerize ◽

Ariane S Tunussi ◽

Joao GR Poco

Keyword(s):

Spray Drying ◽

Innovative Technology ◽

Pharmaceutical Ingredients

In-Flow Flash Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles for Spray-Drying Formulations

10.26434/chemrxiv.8074508.v1 ◽

2019 ◽

Author(s):

Bruno Cerra ◽

Mosca Gabriele ◽

Maurizio Ricci ◽

Aurelie Schoubben ◽

Antimo Gioiello

Keyword(s):

Spray Drying ◽

Marked Improvement ◽

Sem Analysis ◽

Flash Nanoprecipitation ◽

Aerodynamic Properties ◽

Economic Method ◽

Physical Mixing ◽

Size Controlled

<p>In this work we report the development of a cheap and scalable flow-based flash nanoprecipitation approach to prepare D-leucine nanoparticles particularly useful as glidants in dry powder for inhalation. Starting from preliminary batch screens, the process was successfully optimized and scaled-up under mesofluidic conditions. The nebulization with both mini and nano spray-dryer, the SEM analysis of nanoparticles and the aerodynamic evaluation of a formulation obtained by physical mixing of atomized D-leucine powders with budenoside showed an excellent decrease in particle size without altering the morphology, and a marked improvement in the aerodynamic properties of the drug. This simple and economic method by physical mixing of leucine with micronized active pharmaceutical ingredients can represent a valid alternative to co-spray-drying.</p>

Spray Drying for Direct Compression of Pharmaceuticals

Processes ◽

10.3390/pr9020267 ◽

2021 ◽

Vol 9 (2) ◽

pp. 267

Author(s):

Nizar Al-Zoubi ◽

Shadi Gharaibeh ◽

Ahmad Aljaberi ◽

Ioannis Nikolakakis

Keyword(s):

Spray Drying ◽

High Speed ◽

Cost Effective ◽

Effective Drug ◽

Direct Compression ◽

Particle Engineering ◽

Flow Properties ◽

Drug Manufacturing

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, most active pharmaceutical ingredients (APIs) and excipients lack the compression and flow properties required to meet the needs of high-speed industrial tablet presses. Therefore, the majority of DC APIs and excipients are modified via processing/co-processing particle engineering techniques to boost their properties. Spray drying is one of the most commonly employed techniques to prepare DC grades of APIs and excipients with prominent advantages. This review aims to present an overview of the commercially marketed and investigationally-prepared DC APIs and excipients produced by spray drying.

Reversed-Phase High Performance Liquid Chromatographic Analysis of Three First Line Anti-Tuberculosis Drugs

Revista de Chimie ◽

10.37358/rc.18.12.6799 ◽

2019 ◽

Vol 69 (12) ◽

pp. 3590-3592

Author(s):

Nela Bibire ◽

Romeo Iulian Olariu ◽

Luminita Agoroaei ◽

Madalina Vieriu ◽

Alina Diana Panainte ◽

...

Keyword(s):

High Performance ◽

Biological Fluids ◽

Gradient Elution ◽

High Performance Liquid Chromatographic ◽

Reversed Phase ◽

Assay Method ◽

First Line ◽

Liquid Chromatographic

Active pharmaceutical ingredients such as isoniazid, pyrazinamide and rifampicin are among the most important first-line anti-tuberculosis drugs. A simple, rapid and sensitive reversed phase-high performance liquid chromatographic assay method for the simultaneous determination of isoniazid, pyrazinamide and rifampicin has been developed. Separation of the interest compounds was achieved in a 10 min chromatographic run in gradient elution mode on a Zorbax SB-C18 stainless steel column (150 � 4 mm, 5 mm) using a guard column containing the same stationary phase. The gradient elution was carried out with a mobile phase of 10% CH3CN aqueous solution for channel A and 50% CH3CN in pH = 6.8 phosphate buffer (20 mM), to which 1.5 mL triethylamine were added for channel B. Quantification of the analyzed substances was carried out spectrophotometrically at 269 nm. Detection limits of 0.48 mg/L for isoniazid, 0.52 mg/L for pyrazinamide and 0.48 mg/L for rifampicin were established for the developed assay method. The present work showed that the proposed analysis method was advantageous for simple and rapid analysis of the active pharmaceutical ingredients in pharmaceuticals and biological fluids.

Numaswitch: an efficient high-titer expression platform to produce peptides and small proteins

AMB Express ◽

10.1186/s13568-021-01204-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Bach-Ngan Nguyen ◽

Florian Tieves ◽

Thomas Rohr ◽

Hilke Wobst ◽

Felix S. Schöpf ◽

...

Keyword(s):

Fermentation Broth ◽

High Titer ◽

New Technology ◽

Expression Platform ◽

Small Proteins ◽

Production Platform ◽

Β Amyloid ◽

Cost Efficient

AbstractThe production of peptides as active pharmaceutical ingredients (APIs) by recombinant technologies is of emerging interest. A reliable production platform, however, is still missing due the inherent characteristics of peptides such as proteolytic sensitivity, aggregation and cytotoxicity. We have developed a new technology named Numaswitch solving present limitations. Numaswitch was successfully employed for the production of diverse peptides and small proteins varying in length, physicochemical and functional characteristics, including Teriparatide, Linaclotide, human β-amyloid and Serum amyloid A3. Additionally, the potential of Numaswitch for a cost-efficient commercial production is demonstrated yielding > 2 g Teriparatide per liter fermentation broth in a quality meeting API standard.