100% visual inspection of tablets produced with continuous direct compression and coating

2022 ◽  
pp. 121465
Author(s):  
Shirin Barimani ◽  
Rok Šibanc ◽  
Dejan Tomaževič ◽  
Robin Meier ◽  
Peter Kleinebudde
Keyword(s):  
Visual Inspection ◽  
Direct Compression

Effect of alternate feedback strategies on performance for a synthetic aircraft visual inspection task

2003 ◽  
Author(s):  
Rahul R. Desai ◽  
Anand K. Gramopadhye ◽  
Brian J. Melloy ◽  
Andrew Duchowski
Keyword(s):  
Visual Inspection ◽  
Feedback Strategies ◽  
Inspection Task

Detection of Leukemia Using Image Processing

2018 ◽  
Vol 8 (4) ◽  
pp. 61
Author(s):  
A. Sivasangari ◽  
G. Sasikumar
Keyword(s):  
Image Processing ◽  
Statistical Analysis ◽  
Early Detection ◽  
Visual Inspection ◽  
Causes Of Death ◽  
Cure Rate ◽  
Blood Disorders ◽  
Detection And Diagnosis ◽  
The Moment ◽  
Early Detection And Diagnosis

Leukemia   disease   is one   of    the   leading   causes   of death   among   human. Its  cure  rate and  prognosis   depends   mainly   on  the  early  detection   and  diagnosis  of   the  disease. At  the  moment, identification  of  blood  disorders  is  through   visual  inspection  of  microscopic  images  by  examining  changes  like  texture, geometry, colour  and   statistical  analysis  of  images . This  project  aims  to  preliminary  of  developing  a  detection  of  leukemia  types  using   microscopic  blood  sample using MATLAB. Images  are  used  as  they  are  cheap  and  do  not  expensive  for testing  and  lab  equipment.

Optimization of Microcrystalline Cellulose PH 101, Lactose, and Kollidon® K 30 To Obtain Co-Processed Excipient Through Spray Drying

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Kusuma P. ◽  
Syukri Y ◽  
Sholehuddin F. ◽  
Fazzri N. ◽  
Romdhonah . ◽  
...  
Keyword(s):  
Spray Drying ◽  
Microcrystalline Cellulose ◽  
Chemical Change ◽  
Direct Compression ◽  
Flow Properties ◽  
Scanning Calorimetry ◽  
Compression Process ◽  
Infrared Spectrophotometer ◽  
Physical Mixtures ◽  
Spray Dried

The most efficient tablet processing method is direct compression. For this method, the filler-binder can be made by coprocessing via spray drying method. The purpose of this study was to investigate the effect of spray dried co-processing on microcrystalline cellulose (MCC) PH 101, lactose and Kollidon® K 30 as well as to define the optimum proportions. Spray dried MCC PH 101, lactose, and Kollidon® K 30 were varied in 13 different mixture design proportions to obtain compact, free-flowing filler-binder co-processed excipients (CPE). Compactibility and flow properties became the key parameters to determine the optimum proportions of CPE that would be compared to their physical mixtures. The result showed that the optimum proportion of CPE had better compactibility and flow properties than the physical mixtures. The optimum CPE, consisting of only MCC PH 101 and Kollidon® K 30 without lactose, that were characterized using infrared spectrophotometer, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and scanning electron microscope (SEM) indicated no chemical change therein. Therefore, this study showed that spray dried MCC PH 101, lactose and Kollidon® K 30 could be one of the filler-binder alternatives for direct compression process.

Gastroretentive System of Fluvastatin Sodium by Using Natural Mucilage and Synthetic Polymer

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Umamaheswara G. ◽  
Anudeep D.
Keyword(s):  
Half Life ◽  
Release Kinetics ◽  
Kinetic Studies ◽  
Diffusion Path ◽  
Synthetic Polymer ◽  
In Vitro Dissolution ◽  
Direct Compression ◽  
Drug Content ◽  
Biological Half Life

Fluvastatin sodium is a novel compound used as cholesterol lowering agent which acts through the inhibition of 3- hydroxyl-3- methyl glutaryl- coenzyme A (HMG-Co A) reductase. It has short biological half life (1-3h) in humans required a dosing frequency of 20 to 40mg twice a day. Due to its short variable biological half life it has been developed to a sustained gastroretentive system with a natural and synthetic polymer and to study how far the natural mucilage improves the sustained activity. Floating tablets were prepared by direct compression method using in combination of natural mucilage and synthetic polymer. Prior to the preparation of tablets the physical mixtures were subjected to FT IR studies and pre compression parameters. After preparation of tablets they were subjected to various tests like swollen index, drug content, In vitro dissolution and release kinetics with pcp disso software etc. The tablets prepared by direct compression shown good in thickness, hardness and uniformity in drug content, the prepared tablets floated more than 12h except FS1 and FS2 shows 9 and 11h. Swollen index studies shows with increase in concentration of polymer the swelling increases the diffusion path length by which the drug molecule may have to travel and cause lag time. In vitro results shows that on increasing the amount of hibiscus polymer the sustain activity is increased because of its integrity and forms a thick swollen mass and reduces the erosion property of the HypromelloseK100M, kinetic studies shows that FS 1, FS2, FS3 followed the Korsmeyer peppas model and the rest FS 4, FS 5, FS6 follows the zero order respectively. Based on n value indicating that the drug release followed super case II transport mechanism due to the erosion of the polymer.

Detection of early occlusal caries of the first permanent molar using different techniques (An in vivo study)

2019 ◽  
Vol 31 (1) ◽  
pp. 1-8
Author(s):  
Samah F. Al-Qazzaz ◽  
Abeer M. Hassan
Keyword(s):  
Sensitivity And Specificity ◽  
Visual Inspection ◽  
Caries Detection ◽  
Occlusal Caries ◽  
Clinical Sensitivity ◽  
Permanent Molar ◽  
Permanent Molars ◽  
Early Caries ◽  
First Permanent Molars ◽  
Better Than

Background: Molars and premolars are considered as the most vulnerable teeth of caries attack, which is related to the morphology of their occlusal surfaces along with the difficulty of plaque removal. different methods were used for early caries detection that provide sensitive, accurate preoperative diagnosis of caries depths to establish adequate preventive measures and avoid premature tooth treatment by restoration. The aim of the present study was to evaluate the clinical sensitivity and specificity rates of DIAGNOdent and visual inspection as opposed to the ICDAS for the detection of initial occlusal caries in noncavitated first permanent molars. Materials and Methods: This study examined 139 occlusal surface of the first permanent molar pooled from fifty patients aged 8-9 years by three methods. The selected criteria include one occlusal site per tooth (first permanent molars) with carious lesions range from 0 to 3 according to ICDASII (gold standard) visual criteria then the clinical sensitivity and specificity of visual inspection according to Ekstrand et al.in 1997 and DIAGNOdent were performed. . Results: the highest correlation was found between the ICDASII and DIAGNOdent. The sensitivity of the DIAGNOdent for the enamel caries detection (D1) was better than that of visual inspection. The sensitivity and the specificity for the DIAGNOdent at D3 threshold were better than the D1 threshold and the visual inspection method. Conclusion: DIAGNOden pen can be used as a tool for early caries detection in cases of difficult diagnosis that provide good additional sensitivity to the visual inspection.

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