Linear Mixed Model Analysis: Determining if Pretreatment PSA Kinetics Predict Short Term and Long Term Post Treatment PSA Changes After Radiation Therapy for Localized Prostate Cancer

2007 ◽  
Vol 69 (3) ◽  
pp. S315-S316
Author(s):  
R. Roberts ◽  
D. Soto ◽  
J. Taylor ◽  
C. Pan ◽  
H. Sandler
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Localized Prostate Cancer ◽  
Short Term ◽  
Mixed Model Analysis ◽  
Psa Kinetics ◽  
Linear Mixed Model Analysis

Size-related boldness is not altered by stomach flushing in a terrestrial salamander

2021 ◽  
pp. 1-6
Author(s):  
Sebastiano Salvidio ◽  
Andrea Costa ◽  
Fabrizio Oneto
Keyword(s):  
Body Condition ◽  
Mixed Model ◽  
Linear Mixed Model ◽  
Animal Personality ◽  
Model Analysis ◽  
Mixed Model Analysis ◽  
Linear Mixed Model Analysis ◽  
Before And After ◽  
Trophic Strategy ◽  
The Relationship

Abstract Animal personality is a relatively neglected field in amphibian research. In this study we assessed the influence of stomach flushing, a non-lethal technique used in amphibian dietary studies, on the boldness behaviour of the cave salamander Speleomantes strinatii. The time of emergence from a shelter located in an unfamiliar environment (a proxy for individual boldness) was measured in 26 cave salamanders before and after stomach flushing, while 14 non-flushed salamanders were tested as controls. Boldness was a repeatable behaviour for salamanders and larger individuals emerged from their shelter more rapidly than smaller ones. Linear mixed model analysis showed that flushing, sex and body condition had no effect on this behaviour. These findings are promising in the framework of the study of salamander personality. In particular, our results will be useful when exploring the relationship between individual trophic strategy and boldness, aggression or exploration behaviours in terrestrial salamanders.

scholarly journals Combined Androgen Blockade in Localized Prostate Cancer Treated With Definitive Radiation Therapy

2019 ◽  
Vol 17 (12) ◽  
pp. 1497-1504
Author(s):  
Lucas K. Vitzthum ◽  
Chris Straka ◽  
Reith R. Sarkar ◽  
Rana McKay ◽  
J. Michael Randall ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
High Risk ◽  
Cox Proportional Hazards ◽  
Hazard Ratio ◽  
Short Term ◽  
Combined Androgen Blockade ◽  
Significant Difference ◽  
Androgen Blockade

Background: The addition of androgen deprivation therapy to radiation therapy (RT) improves survival in patients with intermediate- and high-risk prostate cancer (PCa), but it is not known whether combined androgen blockade (CAB) with a gonadotropin-releasing hormone agonist (GnRH-A) and a nonsteroidal antiandrogen improves survival over GnRH-A monotherapy. Methods: This study evaluated patients with intermediate- and high-risk PCa diagnosed in 2001 through 2015 who underwent RT with either GnRH-A alone or CAB using the Veterans Affairs Informatics and Computing Infrastructure. Associations between CAB and prostate cancer–specific mortality (PCSM) and overall survival (OS) were determined using multivariable regression with Fine-Gray and multivariable Cox proportional hazards models, respectively. For a positive control, the effect of long-term versus short-term GnRH-A therapy was tested. Results: The cohort included 8,423 men (GnRH-A, 4,529; CAB, 3,894) with a median follow-up of 5.9 years. There were 1,861 deaths, including 349 resulting from PCa. The unadjusted cumulative incidences of PCSM at 10 years were 5.9% and 6.9% for those receiving GnRH-A and CAB, respectively (P=.16). Compared with GnRH-A alone, CAB was not associated with a significant difference in covariate-adjusted PCSM (subdistribution hazard ratio [SHR], 1.05; 95% CI, 0.85–1.30) or OS (hazard ratio, 1.02; 95% CI, 0.93–1.12). For high-risk patients, long-term versus short-term GnRH-A therapy was associated with improved PCSM (SHR, 0.74; 95% CI, 0.57–0.95) and OS (SHR, 0.82; 95% CI, 0.73–0.93). Conclusions: In men receiving definitive RT for intermediate- or high-risk PCa, CAB was not associated with improved PCSM or OS compared with GnRH alone.

scholarly journals How does initial treatment choice affect short-term and long-term costs for clinically localized prostate cancer?

Cancer ◽  
2010 ◽  
Vol 116 (23) ◽  
pp. 5391-5399 ◽  
Author(s):  
Claire F. Snyder ◽  
Kevin D. Frick ◽  
Amanda L. Blackford ◽  
Robert J. Herbert ◽  
Bridget A. Neville ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Initial Treatment ◽  
Treatment Choice ◽  
Localized Prostate Cancer ◽  
Short Term

Long-term versus short-term androgen deprivation combined with high-dose radiotherapy for localized prostate cancer: A Spanish multicenter phase III trial.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e15036-e15036 ◽  
Author(s):  
A. Zapatero ◽  
A. Guerrero ◽  
X. Maldonado ◽  
A. Alvarez ◽  
C. González San Segundo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Deprivation ◽  
Phase Iii ◽  
Localized Prostate Cancer ◽  
High Dose ◽  
Short Term ◽  
Phase Iii Trial ◽  
Multicenter Phase
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