Short and long-term outcomes of the peripheral arterial indirect bypass in diabetic patients with chronic limb-threatening ischemia: Single-center case series

Abstract Background Hepatocellular carcinoma (HCC) is one leading cause of cancer mortality often presenting at inoperable stage. The aim of this study was to examine and compare surgically resected, locally ablated, angiologically treated and palliatively treated HCC patients’ short- and long-term outcomes in a single center over 35 year period. Methods All HCC diagnosed in Oulu University Hospital between 1983-2018 were identified from hospital records (n=273). Patients underwent hepatic resection (n=49), local ablation (RF, laser ablation or PEI; n=25), angiological treatments (TACE, TAE and SIRT; n=48) or palliative treatment (chemotherapy, best supportive care; n=151). Primary outcomes of the study were postoperative complications within 30 days after the operation, and short- (30- and 90-day) and long-term (1, 3 and 5-year) survival. Results were adjusted with sex, age, comorbidities, cirrhosis, Child-Pugh index points, ASA status, year of operation and stage. Results Surgically resected patients were younger than patients in other groups. Recurrence and local recidives occurred more often in local ablation group and in angiological treatment group (p<0.001). Surgical resection rate was 17.9%. Overall complication rates in surgical resection, local ablation and angiological group were 71.5%, 32.0% and 58.3%, (p<0.001). Major complications in respective groups occurred in 28.6%, 8.0% and 27.1%. Overall survival rates in surgical resection group were at 30 and 90 days, 1-, 3 and 5-years 95.9%, 95.9%, 85.1%, 59.0% and 51.2%. In local ablation group, respective overall survival rates were 100.0%, 100.0%, 86.1%, 43.1% and 18.8%, and in angiological group 95.8%, 93.6%, 56.1%, 26.3% and 6.6%. In cox regression model adjusted for confounding factors, local ablation and angiological treatment were significant risk factors for mortality. Prognosis was poor in palliatively treated patients. Conclusions Based on our study on Northern Finland population, the surgical resection of HCC seems to be the most effective treatment considering long-term survival and tumor recurrence after adjustment for confounding factors.

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Short- and long-term outcomes of laparoscopic liver resection: a single-center, retrospective, matched-pair analysis

HPB ◽

10.1016/j.hpb.2019.10.749 ◽

2019 ◽

Vol 21 ◽

pp. S799

Author(s):

K. Kouladouros ◽

C. Justinger ◽

D. Gärtner ◽

I. Tournas ◽

M.R. Schön

Keyword(s):

Liver Resection ◽

Laparoscopic Liver Resection ◽

Matched Pair ◽

Single Center ◽

Long Term Outcomes ◽

Matched Pair Analysis ◽

Short And Long Term ◽

Pair Analysis

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Short- and long-term outcomes in Middle Eastern diabetic patients after percutaneous coronary intervention: results from The First Jordanian PCI Registry (JoPCR1)

Diabetology International ◽

10.1007/s13340-016-0273-z ◽

2016 ◽

Vol 8 (1) ◽

pp. 30-38 ◽

Cited By ~ 3

Author(s):

Ayman J. Hammoudeh ◽

Ramzi Tabbalat ◽

Imad A. Alhaddad ◽

Yousef Khader ◽

Mohamad Jarrah ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Middle Eastern ◽

Coronary Intervention ◽

Diabetic Patients ◽

Long Term Outcomes ◽

Percutaneous Coronary ◽

Short And Long Term

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Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation

Canadian Association of Radiologists Journal ◽

10.1016/j.carj.2016.12.007 ◽

2017 ◽

Vol 68 (2) ◽

pp. 171-177 ◽

Cited By ~ 16

Author(s):

Francesco Giurazza ◽

Gianluigi Guarnieri ◽

Kieran J. Murphy ◽

Mario Muto

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Case Series ◽

Radicular Pain ◽

Motor Deficits ◽

Injection Technique ◽

Low Back ◽

Long Term Outcomes ◽

Short And Long Term

The management of low back pain should always start with a conservative approach; however, when it fails, intervention is required and at that moment the most appropriate choice remains unclear. Before invasive surgery, minimally invasive techniques can be adopted. In European trials and in a trans-Canadian clinical trial 03 ozone has been used successfully. In total over 50,000 patients have been treated safely. Ozone is a gas normally present in the atmosphere with potent oxidizing power; it has been used for percutaneous intradiscal injection combined with oxygen (O2O3) at very low concentrations for 15 years in Europe. The main indication is back pain with or without radicular pain but without motor deficits, which is refractory to 4-6 weeks of conservative therapies. Its mechanism of action on the disc is mechanical (volume reduction by subtle dehydration of the nucleus pulposis) and antinflammatory. The intradiscal ozone injection is performed with a thin needle (18-22 gauge) image guided by computed tomography or angiofluoroscopy and is usually complimented by periganglionic injection of corticosteroids and anesthetics. This combination gives immediate pain relief and allows time for the ozone to act. It is a cost-effective procedure that presents a very low complication rate (0.1%). The radicular pain is resolved before the back pain does, as is seen with microdiscectomy. Peer-reviewed publications of large randomized trials, case series, and meta analysis from large samples of patients have demonstrated the procedure to be safe and effective in the short and the long terms, with benefits recognized up to 10 years after treatment. We aim to review the principles of action of O2O3 and report the injection techniques, complications, and short- and long-term outcomes.

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