The effect of acupuncture stimulation on alleviating emotional changes due to acute alcohol administration and the possibility of sigma1 receptor involvement

ABSTRACT The effect of ethyl alcohol on the circulating eosinophil cells has been studied in female albino rats. An intoxicating dose of alcohol caused a marked depletion of circulating eosinophils which was most clearly evident four hours after the administration of the alcohol. The initial values were not reached before 24 hours had elapsed. Intraperitoneal injection of vitamin C 12 hours prior to the alcohol administration very effectively prevented this eosinopenic reaction. The mechanism of regulation of the eosinophil cells in the circulation has been discussed in the light of previous results and of those obtained in this study.

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A Qualitative Study on the Emotional Changes Experienced by Elementary School Teachers in Operational Process of Parent Counseling Week

The Journal of Elementary Education ◽

10.29096/jee.33.1.01 ◽

2020 ◽

Vol 33 (1) ◽

pp. 1-30

Author(s):

JoonSup Choi

Keyword(s):

Elementary School ◽

Qualitative Study ◽

Elementary School Teachers ◽

School Teachers ◽

Operational Process ◽

Emotional Changes ◽

Parent Counseling

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Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway

International Journal of Molecular Sciences ◽

10.3390/ijms22084037 ◽

2021 ◽

Vol 22 (8) ◽

pp. 4037

Author(s):

Su Yeon Seo ◽

Se Kyun Bang ◽

Suk Yun Kang ◽

Seong Jin Cho ◽

Kwang Ho Choi ◽

...

Keyword(s):

Negative Emotions ◽

Acupuncture Point ◽

Repeated Administration ◽

Ultrasonic Vocalizations ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Alcohol Administration ◽

Heart Meridian ◽

Mature Brain ◽

Neurotropic Factor

The Shenmen point (acupuncture point heart 7: HT7), located in the heart meridian, is frequently used to treat mental disorders, including drug addiction, anxiety, and depression. This study aimed to determine how HT7 regulates anxiety and negative emotions caused by repeated alcohol administration, focusing on the amygdala and paraventricular nucleus (PVN). Repeated administration of alcohol (ETOH; 2 g/kg, i.p. injection, 16% v/v) for 14 days increased the corticosterone (CORT) levels, and HT7 stimulation reduced the plasma CORT levels. HT7 stimulation mitigated anxiety-like behaviors and reduced 22-kHz ultrasonic vocalizations in rats receiving repeated ETOH injections. HT7 stimulation increased the amygdala expression of mature brain-derived neurotropic factor (mBDNF) and phosphorylated tropomyosin receptor kinase B (pTrkB) and decreased the PVN corticotropin-releasing hormone (CRH) expression. Amygdala microinjections of the TrkB antagonist ANA-12 (0.1 pmol/1 μL) reversed the increase in PVN CRH levels. The reduced PVN CRH levels were regulated by CRH-expressing neurons in the amygdala, and the increased amygdala CRH levels were affected by the HT7-stimulation induced increases in mBDNF. HT7 stimulation alleviates increased stress hormone levels and mitigates anxiety and negative emotions caused by repeated ETOH administration. These results provide scientific support for the clinical use of acupuncture to treat various alcoholism-induced diseases.

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THE EFFECT OF CHRONIC ALCOHOL ADMINISTRATION UPON CARDIAC NUCLEOTIDE CONCENTRATIONS AND HISTOMORPHOMETRY

Biochemical Society Transactions ◽

10.1042/bst022352s ◽

1994 ◽

Vol 22 (3) ◽

pp. 352S-352S

Author(s):

VINOOD B. PATEL ◽

JONATHAN R. SALISBURY ◽

LORETA M. RODRIGUES ◽

JOHN R. GRIFFITHS ◽

PETER J. RICHARDSON ◽

...

Keyword(s):

Chronic Alcohol ◽

Alcohol Administration ◽

Chronic Alcohol Administration

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Acute and chronic alcohol administration: Effects on performance of zebrafish in a latent learning task

Behavioural Brain Research ◽

10.1016/j.bbr.2014.12.013 ◽

2015 ◽

Vol 282 ◽

pp. 76-83 ◽

Cited By ~ 20

Author(s):

Ana C. Luchiari ◽

Diana C. Salajan ◽

Robert Gerlai

Keyword(s):

Learning Task ◽

Latent Learning ◽

Chronic Alcohol ◽

Alcohol Administration ◽

Chronic Alcohol Administration

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Effect of acupuncture stimulation on rats with depression induced by water-immersion stress

Neuroscience Letters ◽

10.1016/j.neulet.2016.02.051 ◽

2016 ◽

Vol 618 ◽

pp. 99-103 ◽

Cited By ~ 9

Author(s):

Nobuyuki Tanahashi ◽

Ken Takagi ◽

Nozomi Amagasu ◽

Guifeng Wang ◽

Kaito Mizuno ◽

...

Keyword(s):

Water Immersion ◽

Acupuncture Stimulation

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Cerebral Cortex Participation in the Physiological Mechanisms of Acupuncture Stimulation: A Study by Auditory Endogenous Potentials (P300)

The American Journal of Chinese Medicine ◽

10.1142/s0192415x98000300 ◽

1998 ◽

Vol 26 (03n04) ◽

pp. 265-274 ◽

Cited By ~ 8

Author(s):

Ching-Liang Hsieh ◽

Tsai-Chung Li ◽

Chien-Yu Lin ◽

Nou-Ying Tang ◽

Qwang-Yuen Chang ◽

...

Keyword(s):

Cerebral Cortex ◽

Control Period ◽

Physiological Mechanism ◽

The Body ◽

Physiological Mechanisms ◽

Neuropsychological Effects ◽

Acupuncture Stimulation ◽

Significant Difference ◽

Acupoint Specificity ◽

Stimulation Of

Although acupuncture has traditionally used the acupoints formula to treat diseases, the physiological mechanisms involved and the effectiveness of therapy remain unclear. This study investigated the physiological mechanism(s) and response to acupuncture stimulation using the acupoints formula. Scalp-recorded potentials P300 were evoked by auditory stimulation of non-target and target in 13 normal adult volunteers. Latencies and amplitudes were measured. Three assessments were performed in each subject over a period of at least one week. Each assessment was divided into a control period with no acupuncture stimulation, followed by an acupuncture period and then a post-acupuncture period. Acupuncture needles were inserted into the body as follows: 1) non-acupoint: acupuncture needles were inserted 2 cm lateral to both Zusanli acupoints; 2) acupoint: acupuncture needles were inserted into both Zusanli acupoints; 3) acupoints formula: acupuncture needles were inserted into both Zusanli and Shousanli acupoints. Our results showed that both acupoint and acupoints formula assessments resulted in a significant decrease of P300 amplitudes during the acupuncture and post-acupuncture periods. However, there was significant difference in P300 amplitudes in the non-acupoint assessment during these periods. P300 changes in latencies and amplitudes were not significantly different between the acupoint assessment and the acupoints formula assessment. We concluded that acupuncture stimulation of both Zusanli acupoints resulted in a decrease of P300 amplitudes, suggesting the involvement of the cerebral cortex in sensory interaction when simultaneous sensations of the two types are received. No similar changes were observed in the non-acupoint assessment, which have been suggested to be related to so-called acupoint specificity. Results obtained using the acupoints formula were not significantly different from those using acupoints alone. These findings suggested that neuropsychological effects from stimulation of Zusanli acupoints and Shousanli acupoints are different.

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