In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several derivatives against strains of influenza virus

Ethnomedicinally, the family Liliaceae is prominent in controlling skin, wound and fungal infections. A carboxylic fatty acid derivative has been isolated from Aloe vera leaves and its structure was elucidated on the basis of NMR and FT-IR analysis. The compound was formulated as ointment with the aid of polymer based delivery agent. The ointment and the uncontaminated fatty acid have been scrutinized aimed at their anti-infectious potential. Individually, the pure compound and the formulated ointment exhibited growth inhibitory activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans and Talaromyces flavus. Minimum inhibitory concentration (MIC) values were found to be appreciably low, ranging between 0.30 and 2.50 mg/ml. The formulated ointment displayed highly significant inhibitory activities against all six pathogens compared to the unformulated compound. The MIC values of the ointment ranged between 0.08 and 1.25 mg/g. The in vitro antibiotic activity studies discovered that, both the pure compound and the formulated ointment showed potency against the selected multi-resistant microorganisms tested in the current work. These findings suggest that the isolated carboxylic acid derivative may be beneficial in the discovery of antibiotics highly potent against drug-resistant pathogens. Furthermore, it may add to the improvement of preservatives in the food industry. Lastly, it could be considered as new source of natural antibiotics in the pharmaceutical industry.

Download Full-text

In vitro evaluation of antifungal activity of Aloe vera, Moringa oleifera and Newbouldia laevis on the Strain of Lasiodiplodia theobromae in Region of Kisangani / DR CONGO

Scholars Bulletin ◽

10.36348/sb.2020.v06i05.002 ◽

2020 ◽

Vol 06 (05) ◽

pp. 123-130

Author(s):

Kwembe JTK ◽

Mbula JP ◽

Onautshu O ◽

Mpiana PT ◽

Haesaert G

Keyword(s):

Antifungal Activity ◽

Moringa Oleifera ◽

Aloe Vera ◽

Dr Congo ◽

In Vitro Evaluation ◽

Lasiodiplodia Theobromae

Download Full-text

5.Evaluación de dos medios de cultivo: aloe vera (aloe barbadensis miller) y la pulpa de papel como gelificantes alternativos del agar-agar para la propagación in-vitro de la variedad de papa andinita (SOLANUM TUBEROSUM L)

Revista EDUCARE - UPEL-IPB - Segunda Nueva Etapa 2.0 ◽

10.46498/reduipb.v21i2.53 ◽

2018 ◽

Vol 21 (2) ◽

pp. 58-67 ◽

Cited By ~ 1

Author(s):

Juan Marcos Oviedo Montero (Colegio Pablo VI) ◽

Albany García Montero

Keyword(s):

Solanum Tuberosum ◽

Solanum Tuberosum L ◽

Aloe Vera ◽

Aloe Barbadensis

El estudio tiene como propósito evaluar el efecto de la aplicación de Aloe Vera (Aloe Barbadensis Miller) y la Pulpa de Papel seca como gelificantes alternativos del agar-agar para la preparación de medios de cultivo para la propagación in-vitro de la variedad de papa Andinita (SolanumTuberosum L.). El mismo es realizado bajo el enfoque cuantitativo y paradigma positivista, adoptando un estudio experimental carácter explicativo. El procedimiento se realizó utilizando como base la solución Murashige-Skooge (MS) sustituyendo el agar-agar y aplicando técnicas tradicionales de cultivo in-vitro. La población objeto de estudio estuvo conformada por 300 vitro-plantas de un lote de papa Andinita (SolanumTuberosum L.) pertenecientes al (INIA) de las cuales se tomó como muestra 100 vitro-plantas de dicho lote cultivo. Para el tratamiento se seleccionó un testigo de la vitro-planta el cual tuvo un medio tradicional, mientras que 4 grupos fueron sometidos a diferentes concentraciones de los medios sustitutos para el Agar-Agar. Se espera que esta investigación permita generar medios alternos que contribuyan a la reducción de la utilización del Agar en los medios de cultivos in vitro.

Download Full-text

Transdermal Delivery of Fluconazole ß-cyclodextrin Complex Incorporated in Aloe vera Gel for Fungal Therapy: Development, Characterization and in vitro Evaluation

Indian Journal of Pharmaceutical Education and Research ◽

10.5530/ijper.55.1s.38 ◽

2021 ◽

Vol 55 (1s) ◽

pp. s66-s74

Author(s):

Deepak Aswal ◽

Tanuja Bisht

Keyword(s):

Transdermal Delivery ◽

Aloe Vera ◽

Cyclodextrin Complex ◽

In Vitro Evaluation ◽

Aloe Vera Gel ◽

Therapy Development

Download Full-text

Enhanced in vitro caulogenesis and quantitative estimation of aloin through HPLC in Aloe vera

Israel Journal of Plant Sciences ◽

10.1080/07929978.2014.961388 ◽

2013 ◽

Vol 61 (1-4) ◽

pp. 57-63 ◽

Cited By ~ 2

Author(s):

V. Sharma ◽

M. Guleria ◽

P. Chaudhary

Keyword(s):

Large Scale ◽

Quantitative Estimation ◽

Aloe Vera ◽

Shoot Proliferation ◽

Multiple Shoots ◽

Fold Increase ◽

Nutrient Media ◽

Aloe Barbadensis ◽

Shoot Bud

Aloe vera(Liliaceae) is well known for its medicinal properties. It contains flavonoids, saponins, tannins, alkaloids and other compounds which exhibit medicinal, cosmetic and pharmacological properties. There is a lack of production of aloe leaf to meet the industry demand and therefore the means to facilitate large-scale aloe cultivation schemes need to be developed. Because sexual reproduction by seeds is almost ineffective inAloe veradue to male sterility and vegetative propagation by offshoots is only possible during the growing seasons, there is a need to develop a propagation method to facilitate large-scale cultivation.In vitroregeneration of medicinal plants is important and there is the potential for the production of high-quality plant-based medicine. In the present study, an attempt has been made to enhancein vitrocaulogenesis and aloin content in plants in the presence of a precursor (tryptophan) in the nutrient media. Forin vitroculture establishment and shoot bud multiplication, MS basal media were used supplemented with different concentrations and different combinations of growth regulators such as BAP (6-benzylaminopurine) and IAA (3-indole acetic acid). Shoot proliferation was optimal in MS medium containing 2.0 mg l−1BAP. For evaluation ofin vitroenhancement of aloin production the precursor tryptophan was added to the nutrient media at different levels (5, 10, 15 and 20 mg l−1). Addition of 20 mg l−1tryptophan induced a 2.43-fold increase in aloin content in multiple shoots cultures ofAloe barbadensis.

Download Full-text