Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin

2004 ◽  
Vol 4 (6) ◽  
pp. 763-778 ◽  
Author(s):  
José Leiro ◽  
Juan A Arranz ◽  
Matilde Yáñez ◽  
Florencio M Ubeira ◽  
Manuel L Sanmartı́n ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Nuclear Factor Kappa B ◽  
Expression Profiles ◽  
Signal Transduction Pathway ◽  
Nuclear Factor ◽  
Transduction Pathway ◽  
Nuclear Factor Kappa

scholarly journals Modulation of both activator protein-1 and nuclear factor-kappa B signal transduction of human T cells by amiodarone

2014 ◽  
Vol 240 (1) ◽  
pp. 99-108 ◽  
Author(s):  
Shu-Meng Cheng ◽  
Wei-Hsiang Lin ◽  
Chin-Sheng Lin ◽  
Ling-Jun Ho ◽  
Tsung-Neng Tsai ◽  
...  
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Nuclear Factor Kappa ◽  
Human T Cells

scholarly journals Relocalization of Drosophila dorsal protein can be induced by a rise in cytoplasmic calcium concentration and the expression of constitutively active but not wild-type Toll receptors

1993 ◽  
Vol 296 (2) ◽  
pp. 497-503 ◽  
Author(s):  
K Kubota ◽  
F J Keith ◽  
N J Gay
Keyword(s):  
Signal Transduction ◽  
Protein Kinase ◽  
Nuclear Localization ◽  
Calcium Concentration ◽  
Nuclear Factor Kappa B ◽  
Signal Transduction Pathways ◽  
Nuclear Factor ◽  
Cytoplasmic Calcium ◽  
Wild Type ◽  
Nuclear Factor Kappa

The generation of dorso-ventral polarity in Drosophila relies on the formation of a nuclear gradient of the rel/nuclear factor kappa B transcription factor dorsal in the pre-cellular syncitial embryo by a process of differential nuclear localization. It is thought that the gradient is formed by activation at ventral positions of the membrane receptor Toll that in turn causes the local dissociation of dorsal from the cytoplasmic anchor protein cactus. Although Toll is related in its cytoplasmic domain to the interleukin-1 receptor little is known about the signal transduction pathways that lead from Toll to the relocalization of dorsal. In this paper we have used immunofluorescence microscopy as a direct assay of dorsal protein nuclear localization in the Drosophila cell line Schneider 2. We find that increased cytoplasmic calcium concentration and the expression of constitutively active Toll receptors can induce the relocalization of dorsal. By contrast, we find that activation of endogenous protein kinase A and expression of wild-type Toll receptors, which activate zen-chloramphenicol acetyltransferase reporter genes in this system, have only a marginal effect on the cellular distribution of the dorsal protein. Treatment of cells with activators of protein kinase C and radical oxygen intermediates, both of which activate nuclear factor kappa B, also has little effect on dorsal protein localization. We propose that different threshold levels of dorsal activation can be established by distinctly regulated signal transduction pathways.

scholarly journals Transcriptome and phytochemical analyses provide new insights into long non-coding RNAs and characteristic secondary metabolites of oolong tea (Camellia sinensis) in solar-withering

2019 ◽  
Author(s):  
Chen Zhu ◽  
Shuting Zhang ◽  
Haifeng Fu ◽  
Chengzhe Zhou ◽  
Lan Chen ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Secondary Metabolites ◽  
Metabolic Pathway ◽  
Target Genes ◽  
Expression Profiles ◽  
Signal Transduction Pathway ◽  
Total Flavonoid ◽  
Transduction Pathway ◽  
Oolong Tea ◽  
Non Coding Rnas

Abstract Background Oolong tea, a semi-fermented tea, was deeply loved by consumers. Among tea processing, withering is the first indispensable process for improving the unique flavor. However, the roles of long non-coding RNAs (lncRNAs) and characteristic secondary metabolites in withering of oolong tea remain unknown. Results Using phytochemical analyses, the total flavonoid, total catechins, EGC, CG, GCG, ECG, and EGCG were all present at significantly lower levels in solar-withered leaves (SW) than in fresh leaves (FL) and indoor-withered leaves (IW). However, terpenoid, JA, and MeJA were present at a higher level in SW than FL and IW. By analyzing the transcriptome data, we obtained a total of 32,036 lncRNAs. On the basis of Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, flavonoid metabolic pathway, terpenoid metabolic pathway, and JA/MeJA biosynthesis and signal transduction pathway were the representative pathways in this study. And a total of 63 differentially expressed-lncRNAs (DE-lncRNAs) and 23 target genes were identified in the 3 pathways. Analysis of the expression profiles of DE-lncRNAs and their target genes in SW compared with IW, we found that 4 up-regulated genes (FLS, CCR, CAD, and HCT), 7 up-regulated lncRNAs, 4 down-regulated genes (4CL, CHI, F3H, and F3'H), and 3 down-regulated lncRNAs in flavonoid metabolism; 9 up-regulated genes (DXS, CMK, HDS, HDR, AACT, MVK, PMK, GGPPS, and TPS), 3 up-regulated lncRNAs, 6 down-regulated lncRNAs in terpenoid metabolism; 6 up-regulated genes (LOX, AOS, AOC, OPR, ACX, and MFP2), 4 up-regulated lncRNAs, and 3 down-regulated lncRNAs in JA/MeJA biosynthesis and signal transduction pathway. Conclusions These results suggested that the expression of DE-lncRNAs and their targets involved in the 3 pathways maybe related to the low content of total flavonoid, total catechins, EGC, CG, GCG, ECG, and EGCG, and high content of terpenoid in SW. Moreover, solar light, high content of JA and MeJA, and the endogenous target mimics (eTMs) regulatory mechanism in SW were also crucial factors in increasing the terpenoid. These findings provide new insights into the view of "Kàn qīng shài qīng" that the solar-withering is more contribute to the high quality flavor of oolong tea compared to the indoor-withering.

P87. Peroxynitrite exerts complex and opposite effects on nuclear factor kappa B: A novel redox-based mechanism controlling cell signal transduction

Nitric Oxide ◽  
2008 ◽  
Vol 19 ◽  
pp. 63
Author(s):  
Noureddine Loukili ◽  
Noureddine Loukili ◽  
Sandra Levrand ◽  
Joëlle Rolli ◽  
François Feihl ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Cell Signal ◽  
Nuclear Factor Kappa ◽  
Cell Signal Transduction
Sign in / Sign up

Export Citation Format

Share Document