Forsythiaside A alleviates methotrexate-induced intestinal mucositis in rats by modulating the NLRP3 signaling pathways

2022 ◽  
Vol 103 ◽  
pp. 108466
Author(s):  
Wuying Lang ◽  
Min Cheng ◽  
Xin Zheng ◽  
Yongping Zhao ◽  
Yunlong Qu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Intestinal Mucositis

scholarly journals Chemotherapy-Induced Intestinal Microbiota Dysbiosis Impairs Mucosal Homeostasis by Modulating Toll-like Receptor Signaling Pathways

2021 ◽  
Vol 22 (17) ◽  
pp. 9474
Author(s):  
Ling Wei ◽  
Xue-Sen Wen ◽  
Cory J. Xian
Keyword(s):  
Epithelial Cell ◽  
Signaling Pathways ◽  
Intestinal Microbiota ◽  
Inflammatory Mediators ◽  
Toll Like Receptor ◽  
Mucosal Regeneration ◽  
Epithelial Cell Apoptosis ◽  
Intestinal Mucositis ◽  
Mucosal Homeostasis ◽  
Care Costs

Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–100% of patients undergoing chemotherapy, can reduce the patients’ quality of life, add health care costs and even postpone cancer treatment. In recent years, the relationships between intestinal microbiota dysbiosis and mucositis have drawn much attention in mucositis research. Chemotherapy can shape intestinal microbiota, which, in turn, can aggravate the mucositis through toll-like receptor (TLR) signaling pathways, leading to an increased expression of inflammatory mediators and elevated epithelial cell apoptosis but decreased epithelial cell differentiation and mucosal regeneration. This review summarizes relevant studies related to the relationships of mucositis with chemotherapy regimens, microbiota, TLRs, inflammatory mediators, and intestinal homeostasis, aiming to explore how gut microbiota affects the pathogenesis of mucositis and provides potential new strategies for mucositis alleviation and treatment and development of new therapies.

A compendium of G-protein–coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure

2020 ◽  
Vol 134 (5) ◽  
pp. 473-512 ◽  
Author(s):  
Ryan P. Ceddia ◽  
Sheila Collins
Keyword(s):  
Adipose Tissue ◽  
Energy Expenditure ◽  
Signaling Pathways ◽  
G Protein ◽  
Uncoupling Protein ◽  
Beige Adipocytes ◽  
Nucleotide Regulation ◽  
Ucp1 Expression ◽  
Thermogenic Adipocytes ◽  
G Protein Coupled

Abstract With the ever-increasing burden of obesity and Type 2 diabetes, it is generally acknowledged that there remains a need for developing new therapeutics. One potential mechanism to combat obesity is to raise energy expenditure via increasing the amount of uncoupled respiration from the mitochondria-rich brown and beige adipocytes. With the recent appreciation of thermogenic adipocytes in humans, much effort is being made to elucidate the signaling pathways that regulate the browning of adipose tissue. In this review, we focus on the ligand–receptor signaling pathways that influence the cyclic nucleotides, cAMP and cGMP, in adipocytes. We chose to focus on G-protein–coupled receptor (GPCR), guanylyl cyclase and phosphodiesterase regulation of adipocytes because they are the targets of a large proportion of all currently available therapeutics. Furthermore, there is a large overlap in their signaling pathways, as signaling events that raise cAMP or cGMP generally increase adipocyte lipolysis and cause changes that are commonly referred to as browning: increasing mitochondrial biogenesis, uncoupling protein 1 (UCP1) expression and respiration.

The herbal preparation, STW 5, protects against radiation induced intestinal mucositis

2013 ◽  
Vol 51 (08) ◽  
Author(s):  
MT Khayyal ◽  
MA El-Ghazaly ◽  
DH Abdel-Naby ◽  
D Weiser ◽  
H Abdel-Aziz
Keyword(s):  
Herbal Preparation ◽  
Radiation Induced ◽  
Intestinal Mucositis

Action of curcumin and its synthetic analog CDF on cancer related signaling pathways

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
P Balachandran ◽  
FH Sarkar ◽  
DS Pasco
Keyword(s):  
Signaling Pathways ◽  
Synthetic Analog

Novel therapeutic potential for the herbal preparation, STW 5: Prophylactic measure against intestinal mucositis induced by radiation

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
MT Khayyal ◽  
H Abdel-Aziz ◽  
O Kelber ◽  
MA El-Ghazaly ◽  
R El-Hazek ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Herbal Preparation ◽  
Prophylactic Measure ◽  
Intestinal Mucositis ◽  
Novel Therapeutic

UDCA-LPE modulates different signaling pathways involved in hepatic fibrogenesis

2015 ◽  
Vol 53 (01) ◽  
Author(s):  
J Su ◽  
W Chamulitrat ◽  
W Stremmel ◽  
A Pathil
Keyword(s):  
Signaling Pathways ◽  
Hepatic Fibrogenesis
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