32.3 ASSOCIATIONS OF AGGRESSION WITH IMPULSIVITY AND REACTIVITY (AIR) AND MOOD SYMPTOMS WITH PARENTAL DEPRESSION SYMPTOMS AND FAMILY RISK FOR MOOD DISORDERS

Background: Obsessive compulsive personality disorder (OCPD) is commonly associated with anxiety and mood disorders (AMDs), in which fatigue and executive dysfunction represent key symptoms. Executive dysfunction has also been demonstrated in subjects with OCPD, and is additionally found to be a cardinal feature of fatigue. This study aimed to investigate the associations between fatigue, executive dysfunction, and OCPD in patients with AMDs. Methods: In this cross-sectional study, 85 AMD patients (78% females, mean age 39 ± 11 years) were evaluated for OCPD traits by using the observer-rated Compulsive Personality Assessment Scale. The Multidimensional Fatigue Inventory-20 was used to measure different aspects of fatigue, and the Trail Making Test was employed to assess executive functioning. The Hamilton rating scales were used to evaluate anxiety and depression symptoms. Results: Controlling for potential confounders, there was a significant link between OCPD and mental fatigue (OR, 1.27; 95% CI, 1.02 to 1.58; p = 0.033). No associations were found between the presence of OCPD and other relevant fatigue characteristics, including general fatigue, physical fatigue, reduced activity, and reduced motivation, as well as executive functions. Conclusions: To the best of our knowledge, this study is the first to report associations between OCPD and mental fatigue in patients with AMDs, suggesting mental fatigue as a clinically important symptom when considering particular personality pathologies.

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Cannabidiol as a Treatment for Mood Disorders: A Systematic Review

The Canadian Journal of Psychiatry ◽

10.1177/0706743719895195 ◽

2019 ◽

Vol 65 (4) ◽

pp. 213-227 ◽

Cited By ~ 3

Author(s):

Jairo Vinícius Pinto ◽

Gayatri Saraf ◽

Christian Frysch ◽

Daniel Vigo ◽

Kamyar Keramatian ◽

...

Keyword(s):

Clinical Trials ◽

Mood Disorders ◽

Observational Studies ◽

Case Reports ◽

Health Conditions ◽

Current Evidence ◽

Cochrane Central Register ◽

Level Of Evidence ◽

Mood Symptoms ◽

Affective Symptoms

Objective: To review the current evidence for efficacy of cannabidiol in the treatment of mood disorders. Methods: We systematically searched PubMed, Embase, Web of Science, PsychInfo, Scielo, ClinicalTrials.gov , and The Cochrane Central Register of Controlled Trials for studies published up to July 31, 2019. The inclusion criteria were clinical trials, observational studies, or case reports evaluating the effect of pure cannabidiol or cannabidiol mixed with other cannabinoids on mood symptoms related to either mood disorders or other health conditions. The review was reported in accordance with guidelines from Preferred Reporting Items for Systematic reviews and Meta-Analyses protocol. Results: Of the 924 records initially yielded by the search, 16 were included in the final sample. Among them, six were clinical studies that used cannabidiol to treat other health conditions but assessed mood symptoms as an additional outcome. Similarly, four tested cannabidiol blended with Δ-9-tetrahydrocannabinol in the treatment of general health conditions and assessed affective symptoms as secondary outcomes. Two were case reports testing cannabidiol. Four studies were observational studies that evaluated the cannabidiol use and its clinical correlates. However, there were no clinical trials investigating the efficacy of cannabidiol, specifically in mood disorders or assessing affective symptoms as the primary outcome. Although some articles point in the direction of benefits of cannabidiol to treat depressive symptoms, the methodology varied in several aspects and the level of evidence is not enough to support its indication as a treatment for mood disorders. Conclusions: There is a lack of evidence to recommend cannabidiol as a treatment for mood disorders. However, considering the preclinical and clinical evidence related to other diseases, cannabidiol might have a role as a treatment for mood disorders. Therefore, there is an urgent need for well-designed clinical trials investigating the efficacy of cannabidiol in mood disorders.

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Differences in anxiety and depression symptoms: comparison between older and younger clinical samples

International Psychogeriatrics ◽

10.1017/s1041610215000526 ◽

2015 ◽

Vol 27 (9) ◽

pp. 1523-1532 ◽

Cited By ~ 17

Author(s):

Viviana M. Wuthrich ◽

Carly J. Johnco ◽

Julie L. Wetherell

Keyword(s):

Older Adults ◽

Mood Disorders ◽

Interpersonal Relationships ◽

Age Groups ◽

Anxiety And Depression ◽

Clinical Samples ◽

Depression Symptoms ◽

Social Situations ◽

Younger Adults ◽

Symptom Profiles

ABSTRACTBackground:Anxiety and depression symptoms change over the lifespan and older adults use different terms to describe their mental health, contributing to under identification of anxiety and depression in older adults. To date, research has not examined these differences in younger and older samples with comorbid anxiety and depression.Methods:One hundred and seven treatment-seeking participants (47 older, 60% female, and 60 younger, 50% female) with anxiety and mood disorders completed the Anxiety Disorders Interview Schedule and a symptom checklist to examine differences in symptom severity, symptom profiles and terms used to describe anxiety and mood.Results:The findings indicated several key differences between the presentation and description of anxiety and depression in younger and older adults. Older adults with Social Phobia reported fearing a narrower range of social situations and less distress and interference. Older adults with Generalized Anxiety Disorder (GAD) reported less worry about interpersonal relationships and work/school than younger adults, however, there were no differences between age groups for behavioral symptoms endorsed. Further older adults reported phobia of lifts/small spaces more frequently than younger adults. Depressed older depressed adults also reported more anhedonia compared to younger adults, but no differences in terms of reported sadness were found. Finally, older and younger adults differed in their descriptions of symptoms with older adults describing anxiety as feeling stressed and tense, while younger adults described anxiety as feeling anxious, worried or nervous.Conclusions:Clinicians need to assess symptoms broadly to avoid missing the presence of anxiety and mood disorders especially in older adults.

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Impact of a structured, group-based running programme on clinical, cognitive and social function in youth and adults with complex mood disorders: a 12-week pilot study

BMJ Open Sport & Exercise Medicine ◽

10.1136/bmjsem-2019-000521 ◽

2019 ◽

Vol 5 (1) ◽

pp. e000521

Author(s):

Laura E Keating ◽

Suzanna Becker ◽

Katie McCabe ◽

Jeff Whattam ◽

Laura Garrick ◽

...

Keyword(s):

Quality Of Life ◽

Mood Disorders ◽

Exercise Intervention ◽

Bodily Pain ◽

Cognitive Outcomes ◽

Open Label ◽

Mood Symptoms ◽

Before And After ◽

The Impact

BackgroundIndividuals with mood disorders often report lingering health-related quality of life (HRQOL) and social and cognitive impairments even after mood symptoms have improved. Exercise programmes improve mood symptoms in patients, but whether exercise improves functional outcomes in patients with difficult-to-treat mood disorders remains unknown.DesignWe evaluated the impact of a 12-week structured running programme on cognitive, social and quality-of-life outcomes in participants with difficult-to-treat mood disorders.MethodsIn a prospective, open-label study, patients referred to the St Joseph’s Healthcare HamiltonTeam Unbreakablerunning programme for youth and adults with mood disorders completed a comprehensive assessment battery before and after the 12-week exercise intervention.ResultsWe collected preintervention and postintervention data from 18 participants who improved on the general health, vitality, role of emotions, social functioning and mental health (all p≤0.01) HRQOL subscales. Performance improved on cognitive tests that assessed working memory and processing speed (p≤0.04); there were no improvements in complex executive functioning tasks. Regression analyses indicated that younger age, shorter illness duration and reduced bodily pain predicted social and cognitive outcomes.ConclusionParticipation in a group-based, structured running programme was associated with improved HRQOL and social and cognitive function.

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Infant Mental Health and Variability of Parental Depression Symptoms

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/00004583-200112000-00007 ◽

2001 ◽

Vol 40 (12) ◽

pp. 1375-1382 ◽

Cited By ~ 27

Author(s):

RONALD SEIFER ◽

SUSAN DICKSTEIN ◽

ARNOLD J. SAMEROFF ◽

KARIN D. MAGEE ◽

LISA C. HAYDEN

Keyword(s):

Mental Health ◽

Parental Depression ◽

Infant Mental Health ◽

Depression Symptoms

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Changes in parental depression symptoms during family preservation services

Child Abuse & Neglect ◽

10.1016/j.chiabu.2011.02.005 ◽

2011 ◽

Vol 35 (6) ◽

pp. 448-458 ◽

Cited By ~ 13

Author(s):

Mark Chaffin ◽

David Bard

Keyword(s):

Parental Depression ◽

Family Preservation ◽

Depression Symptoms ◽

Family Preservation Services

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Symptoms of depression are more frequent in non-surgical patients with left lateralization of Temporal Lobe Epilepsy: A systematic review

10.1101/2020.08.20.20178293 ◽

2020 ◽

Author(s):

Graciane Radaelli ◽

Fernanda Majolo ◽

Eduardo Leal-Conceicao ◽

Franscisco Santos ◽

Vinicius Escobar ◽

...

Keyword(s):

Systematic Review ◽

Mood Disorders ◽

Statistical Significance ◽

Surgical Patients ◽

Epileptic Focus ◽

Depression Symptoms ◽

Main Method ◽

Symptoms Of Depression ◽

Prevalence Of Depression ◽

Epileptic Patients

Objective: Considering that the side of epileptogenic focus is a factor that could contribute to depressive and anxiety symptoms, we propose a systematic review searching for the prevalence of depression in TLE in non-surgical patients. Methods: We performed a literature search in PubMed/Medline, Web of Science and PsycNET for data from inception until January 2019. Results: After screening titles and abstracts, only 32 articles met the inclusion criteria. DSM/SCID is the main method utilized to psychiatric diagnosis. The majority of the studies did not perform neuropsychological evaluation. From 24 studies, most clinic cases of lateralization of epileptic focus depression symptoms showed lateralization in the left hemisphere. Nine studies were evaluated for individual depressive diagnosis, therefore, the analyzed data does not present statistical significance between right and left hemispheres. Significance: This study shows mood disorders are prevalent in epileptic patients undergoing clinical treatment. However, to date there is no correlation between lateralization of epilepsy and the prevalence of mood disorders or cognitive impairment. Well-conducted studies are needed to establish the correlation between the epilepsy lateralization and mood disorders.

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Changing parental depression and sensitivity: Randomized clinical trial of ABC's effectiveness in the community

Development and Psychopathology ◽

10.1017/s0954579420000310 ◽

2020 ◽

pp. 1-15 ◽

Cited By ~ 1

Author(s):

Laura Perrone ◽

Steven D. Imrisek ◽

Allison Dash ◽

Melanie Rodriguez ◽

Erasma Monticciolo ◽

...

Keyword(s):

Child Outcomes ◽

Parental Depression ◽

Preliminary Evidence ◽

Depression Symptoms ◽

Community Settings ◽

Intervention Effects ◽

Childhood Experiences ◽

Parental Sensitivity ◽

Adverse Childhood ◽

Parent Outcomes

Abstract Attachment and Biobehavioral Catch-up (ABC) demonstrates efficacy in improving parent and child outcomes, with preliminary evidence for effectiveness in community settings. The objective of this study was to assess the effectiveness of a community-based ABC implementation in improving parent outcomes as well as to examine potential mediators and moderators of intervention effectiveness. Two hundred parents and their 5- to 21-month-old infants recruited from an urban community were randomly assigned to receive ABC or be placed on a waitlist. The majority of participants had a minority racial or ethnic background. Before intervention, parents completed questionnaires about sociodemographic risk and adverse childhood experiences. At both baseline and follow-up, parents reported depression symptoms and were video-recorded interacting with their infant, which was coded for sensitivity. The ABC intervention predicted significant increases in parental sensitivity and, among parents who completed the intervention, significant decreases in depression symptoms. Changes in parental depression symptoms did not significantly mediate the intervention effects on sensitivity. Risk variables did not moderate the intervention effects. The results indicate that ABC shows promise for improving parent outcomes in community settings, supporting dissemination.

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EnBrace HR for PMS With Prominent Mood Symptoms or Menstrual Related Mood Disorders

Case Medical Research ◽

10.31525/ct1-nct04123483 ◽

2019 ◽

Author(s):

Keyword(s):

Mood Disorders ◽

Mood Symptoms

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Evaluation of mood disorders in bladder cancer patients and their primary caregivers.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.e17013 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. e17013-e17013

Author(s):

Daniel Au ◽

Connor Chestnut ◽

Andrew Brevik ◽

Mateo Kirwan ◽

John A Taylor ◽

...

Keyword(s):

Bladder Cancer ◽

Cancer Patients ◽

Mood Disorders ◽

Short Form ◽

Pearson Correlation ◽

Primary Caregivers ◽

Depression Symptoms ◽

Burden Of Care ◽

Cancer Management ◽

Muscle Invasive

e17013 Background: Mood disorders are prevalent in cancer patients in general and in bladder cancer specifically. New psychiatric diagnoses post-bladder cancer treatment are associated with decreased survival. Bladder cancer management is cost- and labor-intensive from a healthcare and social standpoint. Tools such as Enhanced Recovery After Surgery (ERAS) pathways have been developed to lower this burden of care, but focus entirely on physiologic parameters without addressing the psycho-social burden of bladder cancer or its treatment. Data is lacking regarding prevalence of mood disorders in bladder cancer patients, especially those with non-muscle-invasive disease, their caregivers, and regarding the relationship between patient and caregiver mood disorders. Methods: A cross-sectional dyadic study of 96 bladder cancer patients and their self-designated primary caregivers. Study utilized retrospective chart review and separate telephone interviews of patient and caregiver. Patients must have received initial diagnosis or proven recurrence within the past 24 and 12 months, respectively, and have no metastatic disease. Surveys included Patient Health Questionnaire 9 (PHQ-9) for depression, General Anxiety Disorder-7 (GAD-7) for anxiety, Short Form Health Survey (SF-12) for health-related quality of life, and a financial toxicity measure. Pearson correlation and regression models were used for analysis. Results: 49% (9.3% moderate to severe, 40.2% mild) of bladder cancer patients and 33% of caregivers (7.2% moderate to severe, 24.8% mild) had symptoms of depression. Patients’ PHQ-9 scores were moderately correlated with their caregiver, r = 0.49 (95% CI 0.32,0.63 p < 0.001). GAD-7 scores were not correlated between patient and caregiver r = 0.08 (95% CI 0.12,0.28 p = 0.45). Both patient (r = -0.31, 95%CI -0.48,-0.10 p < 0.004) and caregiver (r = -0.41, 95%CI -0.58,-0.22 p < 0.001) incomes were inversely associated with depression symptoms. Results were similar when stratified by non-muscle-invasive and muscle-invasive status. Conclusions: Depression is common among bladder cancer patients and their caregivers and these symptoms are correlated between patient and their caregiver. This correlation did not appear to hold true with respect to anxiety. Financial situation may play a role as increasing income was negatively correlated with depression symptoms. Patient and caregiver may both experience adverse psycho-social consequences from bladder cancer and treatments and pose a joint opportunity for intervention to lower burden of care.

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