scholarly journals Oncological outcomes in the management of cT1-T2 cN0 penile squamous cell carcinoma

2020 ◽  
Vol 15 (6) ◽  
Author(s):  
Juan Garisto ◽  
Madhur Nayan ◽  
Kamel Fadaak ◽  
Kathy Li ◽  
Advait Pandya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Early Stage ◽  
Care Center ◽  
Tertiary Care ◽  
Oncological Outcome ◽  
Treatment Modalities ◽  
Tertiary Center

Introduction: Squamous cell carcinoma (SCC) of the penis is a rare disease comprising 1% of all male cancer. Options for the management of cT1-T2 cN0 penile SCC include partial penectomy (PP), considered the standard, and brachytherapy (BT), which offers acceptable local disease control and organ preservation. The purpose of our study was to assess and describe the oncological outcome for both treatments in a tertiary care center. Methods: We performed a contemporary retrospective study of patients with early-stage penile cancer treated surgically or by BT at a tertiary center between 2000 and 2016. Demographic, management, and followup data were obtained from an institutional database. Descriptive statistics and survival analysis using Kaplan-Meier plots were calculated. Local and regional recurrences were compared in both groups (BT vs. PP). Results: A total of 51 patients with cT1-T2N0 penile SCC treated with BT (35) and PP (16) were analyzed. Median followup was 37.1 (13.9–68) and 25.4 months (18–52.3) for the BT and PP group, respectively. Recurrence developed in seven (20%) patients treated with BT. Median time to recurrence was 35.2 months (range 2.9–95.8). No recurrences were reported in patients treated with PP. Forty-four (86.2%) patients were alive with no evidence of disease at the last followup. Overall survival was 62.7%. Complications after primary tumor treatment were urethral stenosis (15.7%), penile necrosis (7.8%), and local infection (2%). Conclusions: PP provides acceptable local control with organ preservation in early-stage penile SCC. BT was able to offer organ preservation in 69% of men. Future prospective studies are needed to compare other organ-conserving treatment modalities with PP.

Laryngeal biopsies: are we doing more, and why? A decade of results

2015 ◽  
Vol 130 (1) ◽  
pp. 100-103 ◽  
Author(s):  
S Lim ◽  
P Sau ◽  
L Cooper ◽  
A McPhaden ◽  
K MacKenzie
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Laryngeal Cancer ◽  
Squamous Cell ◽  
Organ Preservation ◽  
Early Stage ◽  
Benign Disease ◽  
Advanced Head ◽  
Benign Pathology ◽  
Histopathological Results

AbstractBackground:Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study aimed to quantify the rate of laryngeal biopsies and record the indications.Method:A retrospective analysis of laryngeal biopsies performed in North Glasgow, Scotland, UK, between 2001 and 2010, was conducted.Results:From 2001 to 2010, 3902 laryngeal biopsies were carried out in North Glasgow. Histopathological results indicated the following diagnoses: squamous cell carcinoma, in 889 cases (23 per cent); dysplasia, in 986 cases (25 per cent); ‘no tumour’, in 913 cases (23 per cent); and benign pathology, in the remaining 1084 cases (28 per cent). There has been a significant increase in the number of biopsies performed after 2004, with the incidence of squamous cell carcinoma and benign disease remaining relatively static.Conclusion:It is hypothesised that organ preservation strategies, endoscopic resection in early stage laryngeal cancer and chemoradiotherapy in advanced head and neck cancer are responsible for the increase in laryngeal biopsies.

Tu1691 - Squamous Cell Carcinoma of Rectum: A Rural Tertiary Care Center Experience

2018 ◽  
Vol 154 (6) ◽  
pp. S-1352-S-1353
Author(s):  
Burt Cagir ◽  
Ashley Berlot ◽  
Hilary Keller
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

scholarly journals Apoptotic Count as a Guide for Histological Grading of Carcinoma Esophagus: A Light Microscopic Study

2009 ◽  
Vol 1 (01) ◽  
pp. 011-014 ◽  
Author(s):  
Ankit Seth ◽  
Asha Agarwal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histological Grade ◽  
Care Center ◽  
Tertiary Care ◽  
P Value ◽  
Histological Grading ◽  
Carcinoma Of The Esophagus ◽  
Carcinoma Of Esophagus

ABSTRACT Background: Many studies have been done in the past on the correlation between apoptotic count and histological grading of different tumors. Aims: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors. Settings and Design: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed. Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40x objective and 10x eyepiece. Apoptotic bodies were counted in each high-power field (HPF). Statistical Analysis Used: Standard error of difference in apoptotic count in different tumor groups found and P value calculated, using Student′s t test. Results: An inverse correlation of the apoptotic count per HPF with the histological grade of the tumor was found. Conclusions: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.

scholarly journals Tatalaksana karsinoma sel skuamosa kanalis akustikus eksternus

2019 ◽  
Vol 49 (1) ◽  
pp. 73
Author(s):  
Ratna Dwi Restuti ◽  
Iman Pradana Maryadi ◽  
Rangga Rayendra Saleh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Treatment Guidelines ◽  
Early Stage ◽  
Surgical Techniques ◽  
Specific Treatment ◽  
Treatment Modalities ◽  
Cancer Center ◽  
Literature Study

Latar belakang: Keganasan pada kanalis akustikus eksternus (KAE) merupakan kasus yang jarang terjadi, kurang dari 0,2 % dari seluruh keganasan pada regio kepala dan leher. Secara histologis, karsinoma sel skuamosa merupakan jenis karsinoma terbanyak, terjadi pada 80% kasus. Karsinoma sel skuamosa KAE masih menjadi tantangan bagi praktisi medis dalam mendiagnosis dan menatalaksana. Tujuan: Hingga saat ini, belum ada algoritma yang spesifik dalam menatalaksana kasus ini, sehingga membutuhkan pengetahuan yang mendalam mengenai anatomi dan teknik pembedahan, serta ditunjang dengan adanya tim multidisiplin dalam menangani kasus keganasan KAE. Laporan kasus: Tulisan ini melaporkan 4 kasus pasien karsinoma sel skuamosa KAE yang menjalani bermacam modalitas tatalaksana dengan keluaran yang bervariasi. Metode: Telaah literatur berbasis bukti mengenai tatalaksana karsinoma sel skuamosa KAE melalui database Cochrane dan Pubmed Medline. Berdasarkan kriteria inklusi dan ekslusi didapatkan satu jurnal yang relevan dengan kasus yang dilaporkan. Hasil: Karsinoma sel skuamosa liang telinga terutama ditatalaksana dengan terapi pembedahan. Modalitas tambahan yang dapat diberikan adalah kemoterapi dan radioterapi. Terapi pembedahan seringkali meninggalkan defek yang besar sehingga memerlukan tindakan rekonstruksi. Kesimpulan: Tatalaksana karsinoma sel skuamosa KAE seringkali membutuhkan pendekatan multidisiplin dan kompleks terutama pada kasus stadium lanjut. Angka harapan hidup yang lebih baik akan dicapai dengan mendiagnosis dan menatalaksana kasus ini secara dini. Background: Cancer of the external auditory canal (EAC) is a rare tumor, representing less than 0.2% of all head and neck cancers. Histologically, squamous cell carcinoma comprises more than 80% of cases. Squamous cell carcinoma (SCC) of the EAC is still a therapeutic challenge for medical specialists in its diagnosis and management. Purpose: Up to date, there is no specific treatment guidelines available due to SCC low incidence. The attending physician must have asubstantial knowledge of literatures as well as anatomy and surgical techniques, supported by an appropriate cancer center with adequate multidisciplinary team to offer the best therapy in accordance with the needs of the cancer clinical stages. Cases: This paper reports 4 cases of squamous cell carcinoma of the EAC which underwent various treatment modalities, and yielded also various outcomes. Method: Evidence based literature study about squamous cell carcinoma of EAC was performed through Cochrane and Pubmed Medline database. Based on inclusion and exclusion criteria, one study was found relevant to these cases. Results: The particular choice of SCC management of EAC is surgery, yet SCC of the EAC requires additional modalities such as chemotherapy and radiotherapy. Surgery often leaves a large defect which requires a reconstructive procedure. Conclusion: Cancer of EAC management requires a multidisciplinary approach, especially it is more complex in the advanced stage of SCC. An early stage diagnosis and prompt management will lead to a better survival rate. 

scholarly journals Retrospective analysis of total laryngectomy with post-operative radiotherapy for CA larynx in a tertiary care centre: a case series

2019 ◽  
Vol 5 (3) ◽  
pp. 653
Author(s):  
S. Mohamed Siddique ◽  
G. Selvarajan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Total Laryngectomy ◽  
Postoperative Radiotherapy ◽  
Tertiary Care ◽  
Case Series ◽  
Treatment Modalities ◽  
Pharyngocutaneous Fistula ◽  
Operative Care

<p class="abstract"><strong>Background:</strong> Squamous cell carcinoma is the most common malignancy of the larynx. Various treatment modalities are available. Recently, total laryngectomy is a viable option as primary treatment or salvage surgery after radiotherapy than organ preservation surgeries. The aim was to analyse the results of the patients with advanced laryngeal cancers treated with total laryngectomy and postoperative radiotherapy.</p><p class="abstract"><strong>Methods:</strong> It is a retrospective study from January 2015 to June 2018 with 16 patients with squamous cell carcinoma of larynx. Detailed history, examination, radiological, endoscopic evaluation of tumour, tissue biopsy proof and staging was done.  </p><p class="abstract"><strong>Results:</strong> Of the 16 patients (15 male and 1 female), 12 patients (75%) were primary cases and 4 patients (25%) were radiorecurrent. 14 patients (87%) had pre-operative tracheostomy done and 2 patients (13%) had undergone direct laryngectomy. All the 16 patients had transglottic growth. All the patients had undergone total laryngectomy with post-operative radiotherapy. No pharyngocutaneous fistula reported. One patient (6%) had neck edema. One patient (6%) had nodal recurrence.</p><p class="abstract"><strong>Conclusions:</strong> Total laryngectomy with post-operative radiotherapy affords a longer period of survival compared to radiotherapy alone. Minimal complications in our study are attributed to thorough pre-operative evaluation, meticulous surgical technique and post-operative care.</p><p class="abstract"> </p>

scholarly journals Treatment Outcomes of Patients with Squamous Cell Carcinoma of the Vulva: The Largest Series from a Tertiary Care Hospital

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Panida Meelapkij ◽  
Prapaporn Suprasert ◽  
Orthai Baisai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Care Center ◽  
Combined Treatment ◽  
Tertiary Care ◽  
Underlying Disease ◽  
Care Hospital ◽  
Significant Difference ◽  
The Common

Objective. To evaluate the outcomes of squamous cell carcinoma (SCCA) of the vulva treated at our tertiary care center. Methods. The medical records of SCCA patients treated between January 2006 and December 2015 were retrospectively reviewed. Results. One hundred forty-five patients met the criteria with the median age of 57 years old, and 58.6% had an underlying disease. The distribution of stages was as follows: IA 6.2%, IB 21.4%, II 26.2%, IIIA 14.5%, IIIB 6.2%, IIIC 9.7%, IVA 9.0%, and IVB 6.9%. One hundred and nine patients underwent surgical intervention and radical local excision with bilateral groin node dissection as the most frequent procedure. Approximately half of the patients received combined treatment with surgery followed by radiation with or without chemotherapy. Recurrence developed in 127 patients after the median follow-up time of one year with the common sites in the groin and vulva region. However, no significant difference in survival occurred in patients with and without groin node recurrence (15 vs. 28 months, P=0.109). The five-year overall survival was 50.8%. Conclusions. The survival of patients with SCCA vulvar cancer was modest. The common failure sites were groin and vulva regions with unfavorable outcomes.

Sign in / Sign up

Export Citation Format

Share Document