scholarly journals Treatment Outcomes of Patients with Squamous Cell Carcinoma of the Vulva: The Largest Series from a Tertiary Care Hospital

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Panida Meelapkij ◽  
Prapaporn Suprasert ◽  
Orthai Baisai
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Care Center ◽  
Combined Treatment ◽  
Tertiary Care ◽  
Underlying Disease ◽  
Care Hospital ◽  
Significant Difference ◽  
The Common

Objective. To evaluate the outcomes of squamous cell carcinoma (SCCA) of the vulva treated at our tertiary care center. Methods. The medical records of SCCA patients treated between January 2006 and December 2015 were retrospectively reviewed. Results. One hundred forty-five patients met the criteria with the median age of 57 years old, and 58.6% had an underlying disease. The distribution of stages was as follows: IA 6.2%, IB 21.4%, II 26.2%, IIIA 14.5%, IIIB 6.2%, IIIC 9.7%, IVA 9.0%, and IVB 6.9%. One hundred and nine patients underwent surgical intervention and radical local excision with bilateral groin node dissection as the most frequent procedure. Approximately half of the patients received combined treatment with surgery followed by radiation with or without chemotherapy. Recurrence developed in 127 patients after the median follow-up time of one year with the common sites in the groin and vulva region. However, no significant difference in survival occurred in patients with and without groin node recurrence (15 vs. 28 months, P=0.109). The five-year overall survival was 50.8%. Conclusions. The survival of patients with SCCA vulvar cancer was modest. The common failure sites were groin and vulva regions with unfavorable outcomes.

scholarly journals Clinicopathological profile of squamous cell carcinoma presenting in Tertiary Care Hospital, Karachi.

2020 ◽  
Vol 27 (05) ◽  
pp. 939-943
Author(s):  
Sameera Asif ◽  
Summera Kanwal ◽  
Tahera Ayub ◽  
Zafar Abbas ◽  
Batool Vazir ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Stage Iv ◽  
Stage Ii ◽  
Stage Iii ◽  
Care Hospital

Objectives: Oral Squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity. The study was done with the aim to determine the clinical pattern of OSCC seen in tertiary care hospital of Karachi, Pakistan. The frequency of neck metastasis in different staging of squamous cell carcinoma was also recorded. Study Design: Retrospective study. Setting: Department of Oral & Maxillofacial Surgery Liaquat College of Medicine and Dentistry. Period: June 2013- July 2016. Material & Methods: It included 35 males and 25 females which presented with different sites and stage of squamous cell carcinoma. Clinically patients were staged as stage I, stage II, stage III and stage IV and comprised of 3, 8, 30 & 19 patients respectively. Patients presented with cancer of buccal mucosa (31 patients), retromolar region (12 patients), maxillary alveolus (8 patients), tongue (2 patients), floor of mouth (4 patients) & lip (3 patients). Right side was most common, 48 patients as compare to left side, 12 patients while lip cancers was in upper lip in all patients including commissure. Results: Total 60 patients were included in the study with the male to female ratio of 1.4:1. No significant association was seen between age and gender of the patient (p-value 0.933). Majority of patients were male involving buccal mucosa (51.67%) as the most frequently involved site followed by retromolar area (20%) and tongue (13.3%). Mean age of patients included in the study was 50.87 ± 5.53. Conclusion: Most of the cases of OSCC were seen in older patients with increased number of cases involving buccal mucosa as their primary site. Majority of the tumors were classified as stage III followed by Stage IV, Stage II and stage 1 respectively.

Tu1691 - Squamous Cell Carcinoma of Rectum: A Rural Tertiary Care Center Experience

2018 ◽  
Vol 154 (6) ◽  
pp. S-1352-S-1353
Author(s):  
Burt Cagir ◽  
Ashley Berlot ◽  
Hilary Keller
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center

scholarly journals 5-year experience with vulval lesions in a tertiary care hospital: series of 115 cases

2020 ◽  
Vol 9 (12) ◽  
pp. 5001
Author(s):  
Ritu Bhat ◽  
Sachin Kolte
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Care Hospital ◽  
Labia Minora ◽  
Number Of Patients ◽  
Rare Tumours ◽  
Wide Range ◽  
Neoplastic Lesions

Background: Wide range of vulval lesions have been described with similar modes of presentation. Benign and inflammatory lesions form the major chunk. Squamous cell carcinoma is the most reported malignant entity. Aim was to review the vulval lesions received in our departmentMethods: We studied the data from the archives of the Department of Pathology for a period of 5 years from January 2014 to December 2018 for vulval biopsies and specimens sent for histopathological examination. The final diagnoses were divided into non-neoplastic, neoplastic and non- specific.Results: Age of women ranged from 22 to 86 years (mean 54.3±3.6) with the maximum number of patients between 50 to 60 years of age. Most common form of clinical presentation was an itchy white elevated lesion on the vulva (72 cases, 62.6%). The most common site for the lesions was labia minora (90 cases, 78.2%). Non neoplastic lesions were seen in 53 cases and neoplastic lesions were seen in 52 cases. There were 28 (53.8%) benign lesions while 24 cases (46.1%) were malignant. Squamous cell carcinoma was the most frequently diagnosed form accounting for 20 cases (83.3%). Rare tumours like Malignant melanoma, Merkel cell carcinoma and Neuroendocrine carcinoma formed 16.6% (n=4). Seven cases were premalignant. Two cases had non-specific histologic diagnosis showing mild chronic inflammation.Conclusions: Previous studies have reported that non-neoplastic lesions form around 70% of cases. However, in our study we found that the non-neoplastic and neoplastic lesions form equal number of cases (46%) which may be attributed to increased awareness or geographical variation.

scholarly journals Pattern of esophageal cancer in tertiary care hospital in North India: a clinicopathological study

2017 ◽  
Vol 5 (4) ◽  
pp. 1405
Author(s):  
Vishal Gupta ◽  
Subash Bhardwaj ◽  
Opinder Kumar Bhagat
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Undifferentiated Carcinoma ◽  
North India ◽  
Histopathological Analysis ◽  
Care Hospital ◽  
Female Ratio

Background: Esophageal cancer is one of the deadliest and eighth most common cancer worldwide. It is the sixth most common cause of cancer related deaths with developing nations making up more than 80% of total cases and deaths. The purpose of this study was to assess the histopathological pattern of esophageal cancer in our region.Methods: In our centre, we analyzed 101 cases of endoscopic esophageal biopsy proven cases of esophageal cancer from January 2014 to June 2016. In most of these cases, dysphagia was the commonest indication of esophageal endoscopy.Results: 65 cases (64.4%) were males and 36 cases (35.6%) were females. Most of the patients were in the age group of 41-60 years. The histopathological analysis revealed squamous cell carcinoma as the most common esophageal cancer (n=61, 60.4%) followed by adenocarcinoma (n=38, 37.6%) and 02 cases of undifferentiated carcinoma (2%).Conclusions: Esophageal cancer is one of the commonest digestive tract malignancy in India. The males are affected more than the females with male to female ratio of 1.8:1. The maximum number of cases being seen in fifth and sixth decade of life. The squamous cell carcinoma is the most common esophageal cancer seen, with middle esophagus being the commonest site. However, the number of cases of adenocarcinoma are on rise.

Epidemiology of Squamous Cell Carcinoma in Response to Different Hazardous Chewing Causes in Lahore, Pakistan-a Unicenter study

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Maria Fareed Siddiqui ◽  
Umair Yaqoob ◽  
Morad Yaser Al Mostafa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Surgery ◽  
Tertiary Care ◽  
Disease Onset ◽  
Previous History ◽  
Care Hospital ◽  
History Of ◽  
Surgery Department

Oral squamous cell carcinoma (OSCC) being the world’s most prevailing and frightening cancerousdisorder lacks the sufficient data in Pakistan despite of its higher magnitude and prevalence. Objective:This study was specifically designed and conducted with the aim to identify the frequency of this disorderalong with causative factors in past three years in a tertiary care hospital of Lahore, Pakistan. Methods:Epidemiological study was conducted using retrospective randomized method and all pre-requisites werefilled. The clinical profiles of patients were collected from Maxillofacial and Oral Surgery Department ofPathology, Mayo Hospital Lahore. Patients who had undergone treatment for OSCC were contacted andinterviewed for information about demographic regions, previous history of malignancy, disease onset,chewing habits, exposure to pesticides, industrial exposure to metals etc. and all particulars were not andcompiled on questionnaire. Results: A total of 54 patients from different districts of Punjab participatedin the study. Percentages for each possible causative chewing habit were calculated and 87.50 % ofpopulation was found addicted to different habits. Genetic factor might have contributed in remaining fordevelopment of OSCC. Conclusions: Informative data provided in this study will be helpful to be used bythe government and private health agencies while designing and planning management of oral healthproblems and allocating health budgets in focusing this issue.

scholarly journals Frequency of different histopathological types of esophageal cancer patients at oncology department of a tertiary care hospital in Karachi

2021 ◽  
Vol 14 (4) ◽  
pp. 161-165
Author(s):  
Zoya Sheikh ◽  
Ghulam Haider ◽  
Khalil Ahmed ◽  
Dr. Bhunisha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Carcinoma Of The Esophagus ◽  
Histopathological Type

Background: Around the globe, carcinoma of the esophagus is the eighth most prevalent cancer with an incidence of 456,000 cases per year and is the sixth cause of cancer mortality. There are two major histological subtypes of carcinoma of the esophagus, esophageal squamous cell carcinoma and adenocarcinoma. The aim of the current study is to evaluate the frequency of different histopathological types of esophageal cancer in patients presenting at the tertiary care hospital of Karachi. Patients and methods: It was a cross-sectional study conducted at the Department of Clinical Oncology, Jinnah Postgraduate Medical Center, Karachi from March 2017 till March 2019. Two hundred and one histologically proven cases of esophageal cancer of in patients of either gender and between 15-80 years of age were included. Patients were interviewed and data regarding age, gender, education, marital status, employment status, addictions like cigarette or huqqa smoking, consumption of pan, betel nut, naswar, or gutka were recorded. Endoscopy and histology and computed tomography scan were performed. Stage, site, grade and type of tumor were noted. SPSS version 23 was used to analyze data. Mean and SD were calculated for quantitative variables. Frequency and percentage were calculated for qualitative variables. A Chi-square test was used to assess the significance between age and gender with type of EC. A p-value≤0.05 was taken as significant. Results: Mean age of the patients was 47.84. The majority of the patients had stage 2 of cancer (42.8%) and lower tumor site (62.2%) Squamous cell carcinoma was the most common histopathological type in 137 patients out of 201 (68%). The age, gender, smoking, consumption of pan, grade, site, and stage of the tumor showed a statistically significant difference when compared with esophageal squamous cell carcinoma and esophageal adenocarcinoma. Conclusion: The burden of esophageal squamous cell carcinoma is dramatically increasing in the Pakistani population and squamous cell carcinoma was the most common histopathological type.

scholarly journals Clinical profile of oral squamous cell carcinoma patients attending a tertiary care hospital

2015 ◽  
Vol 47 (1-2) ◽  
pp. 3-6 ◽  
Author(s):  
Sheikh Shahidur Rahman ◽  
Mrinal Kanti Sarker ◽  
Md Haider Ali Khan ◽  
Sushanta Shekhar Biswas ◽  
Moni Mohan Saha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Major Public Health Problem ◽  
Care Hospital ◽  
Dental Surgery ◽  
Female Ratio

Oral cancer is one of the most common cancer and constitute a major public health problem. It is estimated that more than 90% of all oral neoplasms are oral squamous cell carcinoma. The purpose of the study was to evaluate the clinical profile of patients with oral squamous cell carcinoma for gender, age, education, occupation, personal habits, site of lesion and histological grading. Two hundred and sixteen confirmed cases of oral squarnous cell carcinoma were included in this study. It was conducted over a period of two years from July 2009 to June 2011 in the department of Dental Surgery of Khulna Medical College Hospital. Male female ratio was 1.5: 1. Mean age was 50.46 years. Correlation between two variables ie. level of education and histomorphological pattern of the lesion were found to be statistically nonsignificant (P>0.05). The commonest age of presentation was in the fifth decade of life. Most of the cases reported at advance stages of the disease which often leads to delay in the management. Majority of patients (70.73%) presented with well differentiated squamous cell carcinoma. Tobacco chewing was the major cause for the development of oral carcinoma DOI: http://dx.doi.org/10.3329/bmjk.v47i1-2.22554 Bang Med J (Khulna) 2014; 47 : 3-6

scholarly journals Apoptotic Count as a Guide for Histological Grading of Carcinoma Esophagus: A Light Microscopic Study

2009 ◽  
Vol 1 (01) ◽  
pp. 011-014 ◽  
Author(s):  
Ankit Seth ◽  
Asha Agarwal
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histological Grade ◽  
Care Center ◽  
Tertiary Care ◽  
P Value ◽  
Histological Grading ◽  
Carcinoma Of The Esophagus ◽  
Carcinoma Of Esophagus

ABSTRACT Background: Many studies have been done in the past on the correlation between apoptotic count and histological grading of different tumors. Aims: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors. Settings and Design: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed. Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40x objective and 10x eyepiece. Apoptotic bodies were counted in each high-power field (HPF). Statistical Analysis Used: Standard error of difference in apoptotic count in different tumor groups found and P value calculated, using Student′s t test. Results: An inverse correlation of the apoptotic count per HPF with the histological grade of the tumor was found. Conclusions: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.

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